Research works

Comorbidities in multiple sclerosis: acquired hepatocerebral degeneration mimicking disease progression

A 63-year-old patient with relapsing-remitting multiple sclerosis (MS) and comorbid liver cirrhosis presented with progressive cognitive decline, gait disturbance and elevated serum neurofilament light chain (NfL), suggesting disease progression independent of relapse activity (P...

Mechanisms of Association of Maternal Education and Intent to Vaccinate Children Against COVID-19

BACKGROUND Although higher maternal education is positively associated with many child health–promoting practices, it is more complicated for child vaccination, and the explanatory mechanisms remain unclear. We aimed to examine mechanisms underlying the association of maternal ed...

Cascading displacement in Ethiopia: drought stress, insecurity, and market pressures in the remaking of mobility, settlement, and land claims

Displacement in Ethiopia is often governed and measured as a single event, yet people frequently move through sequential episodes shaped by drought stress, insecurity, and price pressures. Although scholarship on mobility trajectories, repeated displacement, and mobility regimes...

Early life sugar rationing and ageing related diseases, biological ageing and mortality

Early-life nutrition may influence lifelong ageing, yet human evidence is scarce. Using Britain’s postwar sugar rationing as a natural experiment, we examine its long-term effects in 64,809 United Kingdom Biobank participants. Exposure to sugar rationing during the first 1,000 da...

Screening of pre-type 1 diabetes in high-risk paediatric population: a pilot study in Latvia

The incidence of type 1 diabetes (T1D) among the paediatric population in Latvia is gradually increasing, and ~ 50% of patients with newly diagnosed T1D present with diabetic ketoacidosis (DKA). This study aimed to initiate T1D screening for high-risk children to reduce the rate...

Association of early parenteral energy provision with serum phosphorus decline and phosphorus-based refeeding syndrome in critically ill patients with liver cirrhosis: a Korean retrospective observational study

Purpose: Critically ill patients with liver cirrhosis are vulnerable to malnutrition and refeeding-related electrolyte disturbances, particularly with rapid caloric advancement. As hypophosphatemia is a key feature of refeeding syndrome (RFS) and phosphorus homeostasis may be imp...

Mitochondrial aggregates as a novel quality control mechanism and potential relationship to lipofuscinogenesis

Mitochondria employ quality control mechanisms to maintain homeostasis. Under chronic stress, these systems become overwhelmed, causing intramitochondrial aggregates formation. As a potential quality control process when canonical pathways are compromised, we propose a model of m...

X‑ray computed tomography‑based experimental investigation of CO₂ miscible zone formation mechanisms and degree of miscibility

Carbon dioxide capture, utilization, and storage–enhanced oil recovery (CCUS–EOR) depends on the progressive development of CO₂–oil miscibility, yet the pressure-controlled transition from interfacial mass transfer to porous-media miscible-zone propagation remains difficult to qu...

Addressing the influence of nomophobia on mental health among secondary school students in Ethiopia

Nomophobia (No-Mobile-Phone Phobia), defined as the fear or anxiety experienced when individuals are unable to access their smartphones, has emerged as a growing digital wellbeing concern among adolescents worldwide. Although smartphone access continues to expand across Ethiopia,...

The Pythagorean Angle Lattice: Angle Hierarchy and Spectral Structure

Every primitive Pythagorean triple generates an infinite angle-halving hierarchy that recovers the metallic means precisely when c−b equals 1, 2 or 8, and naturally produces a convergent spectral zeta function. We study the Pythagorean Angle Lattice, a countable set of real numbe...

Behind the smile: forensic odontology knowledge, attitudes, and practices among dental students, interns, and practitioners in the Asir region, Saudi Arabia: a cross-sectional study

Abstract Background Forensic odontology contributes to human identification, age estimation, and medico-legal documentation, yet dental personnel’s preparedness in many regions is unclear. This study assessed the knowledge, attitudes, and practices (KAP) regarding forensic odonto...

Monitoring pedestrian walking dynamics under environmental and policy influences in urban spaces

Abstract Understanding how environmental conditions and policy interventions jointly shape pedestrian mobility is essential for designing resilient, adaptive, and human-centered urban spaces. This study presents a computer-vision framework that extracts pedestrian trajectories fr...

Comparison of cardiac adverse event signal profiles for GLP-1 receptor agonists: an analysis of the FAERS database

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are widely used in the management of type 2 diabetes owing to their effectiveness in glycemic control and weight reduction. Given the increasing use of GLP-1RAs, further research is warranted to better understand their cardiac...

Prevalence of hypocalcemia in neonates receiving phototherapy: a systematic review and meta-analysis

Although phototherapy is the standard treatment for neonatal hyperbilirubinemia, its adverse effects cause electrolyte disturbances. Aggregated evidence regarding the prevalence of phototherapy-induced hypocalcemia remains inconsistent across studies. Therefore, this systematic r...

Antibiotic development and a path to access in India

Antibiotic development has historically been concentrated in high-income countries. We discuss how India is emerging as an important centre for antimicrobial development, and the implications for global health and equity of access to life-saving therapies. India is emerging as an...

Petrogenesis and Geodynamics of the Formation of the Dar’ya Foidolite–Foidosyenite Complex of the Ketkap–Yuna Magmatic Province of the Aldan Shield (Russia) from Petrogeochemical Data: Article 2—Petrogenesis

Abstract The study focuses on substantiating the hypothesis of the two-stage and two-level formation of the Darya Complex, which was proposed in the first article of the series. Isotopic and petrogeochemical studies of magmatic rocks from the Dar’ya Complex revealed that primary...

Designing transformative sustainability education: a mixed methods study exploring the values and perspectives of medical students

Abstract Introduction Education for Sustainable Healthcare (ESH) is a novel area of medical education and high-quality evidence to guide effective learning approaches is yet to be established. This study investigates the design of ESH in undergraduate medicine through the lenses...

And the Path — the pattern and its three axes: space, time, probability

Companion document to "The Bearing" (INFLUXION — The Pattern and Space). An exploration notebook, neither proven nor refuted: spacetime is read as a pattern of quantum correlations (entanglement), on three axes — space (the pattern held, reconstructed via mutual information and M...

Rationale and Design of ACO-REAL: A Real-World Non-Interventional Study of Acoramidis in Routine Clinical Practice

Acoramidis, an oral transthyretin stabilizer that achieves near-complete stabilization, is approved for the treatment of transthyretin amyloid cardiomyopathy (ATTR-CM) based on the phase 3 study, ATTRibute-CM (NCT03860935). To complement trial data, ACO-REAL (NCT07235462) was des...

Incidental perioperative detection of congenital methemoglobinemia: A prospective case series from a South Indian referral centre

Background Congenital methemoglobinemia is a rare inherited disorder caused by impaired reduction of methemoglobin to functional hemoglobin, resulting in functional hypoxia despite normal arterial oxygen tension. Due to its often-mild clinical phenotype, diagnosis is frequently d...