Research works

PLASMID PROFILING AND POST-CURING ANTIBIOTIC SUSCEPTIBILITY EVALUATION OF SELECTED MULTIDRUG-RESISTANT SURGICAL SITE INFECTION BACTERIAL ISOLATES

Background: Multidrug-resistant (MDR) bacterial pathogens associated with surgical site infections (SSIs) represent a major therapeutic challenge due to widespread dissemination of plasmid-mediated antimicrobial resistance. Characterizing plasmid profiles and determining the cont...

THE HISTOLOGICAL AND BIOCHEMICAL EFFECTS OF THE N-HEXANE FRACTION OF TELFAIRIA OCCIDENTALIS LEAVES ON THE LIVER OF STREPTOZOTOCIN-INDUCED DIABETIC WISTAR RATS

Introduction: DM is a metabolic disorder that not only impairs pancreatic function but also disrupts liver protein balance and compromises hepatic structural integrity. Aim: To assess the effect of the n-hexane fractions of TO (nHFTO) leaves extracts on liver injury caused by DM....

A TYPICAL VIRAL PNEUMONIA MASQUERADING AS A TROPICAL ILLNESS

We present a case of a 1 4-year-old female from Mumbai who was referred to Tirunelveli Medical College and Hospital (TVMCH) with a 1 4-day history of high-grade intermittent fever, followed by progressive breathlessness and non-productive cough. Initial investigations revealed th...

PHYTOCHEMICAL SCREENING AND ANTIOXIDANT EVALUATION OF LANTANA CAMARA FLOWER EXTRACTS

Lantana camara, popularly called as Spanish flag and wild sage, belonging to the family Verbenaceae, is majorly distributed across India, notably in Jammu and Kashmir, South India, Himachal Pradesh, Uttar Pradesh, Maharashtra, and several other regions. Lantana camara is most wid...

SCOPE OF AGADATANTRA IN ENVIRONMENTAL POLLUTION WITH SPECIAL REFERENCE TO JANAPADODHWANSA

The escalation of global industrialization has made environmental degradation a primary driver of both acute and chronic human pathologies. Modern public health systems struggle to contain the multi-systemic impact of chemical, atmospheric, and aquatic toxins. This review examine...

FRUITS OF ROSA BRUNONII LINDL. – AN EFFICIENT BIOREAGENT FOR REMOVAL OF TOXIC DYES FROM WATER

Ripened fruits of Rosa brunonii Lindl. have been collected from Badshahithaul, located in the Chamba block of Tehri district, Uttarakhand, India. Different parts of fruits viz. whole fruit (500 mg), seeds (500 mg) and deseeded peel with pulp (500 mg), have been separately treated...

BRONCHIAL ASTHMA:: HOMEOPATHIC APPROACH

Bronchial asthma is a chronic inflammatory disease of the airways characterized by reversible airflow obstruction, bronchial hyper-responsiveness, and recurrent episodes of wheezing, dyspnoea, chest tightness, and cough. Climatic conditions, particularly the monsoon season, signi...

A PROSPECTIVE OBSERVATIONAL STUDY ON EVALUATION OF RATIONAL USE OF ANTIBIOTICS, OUTCOME AND IMPACT OF PATIENT EDUCATION ON MEDICATION ADHERENCE AND QUALITY OF LIFE IN PNEUMONIA PATIENTS IN A TERTIARY CARE HOSPITAL: A PILOT STUDY.

Background: Pneumonia is a major cause of morbidity and mortality worldwide and is commonly treated with antibiotics. Irrational antibiotic use contributes to antimicrobial resistance, prolonged hospitalization, increased healthcare costs, and poor clinical outcomes. Clinical pha...

A RANDOMIZED OPEN LABELLED CONTROLLED CLINICAL STUDY TO EVALUATE THE EFFICACY OF AMLAKYADI GHRITA AND SHATAVARI GHRITA NASYA IN THE MANAGEMENT OF RAJONIVRITTIJANYA LAKSHANAS W.S.R. POST MENOPAUSAL SYNDROME

Background: Menopause is a physiological transition characterized by permanent cessation of menstruation due to ovarian follicular depletion and declining estrogen levels. The associated vasomotor, psychological, musculoskeletal, and urogenital symptoms substantially impair the q...

CLINICAL OUTCOMES OF INDIVIDUALIZED HOMEOPATHIC TREATMENT COMBINED WITH ARDHA SARVANGASANA IN PATIENTS WITH LOWER LIMB SWELLING, CELLULITIS, VARICOSE VEINS, AND VARICOSE ULCERS: A PROSPECTIVE OBSERVATIONAL STUDY

Chronic venous disorders include lower-limb edema, varicose veins, cellulitis, and venous ulcers. Venous hypertension, valve incompetence, impaired calf-muscle pump function, inflammation, obesity, prolonged standing, age, pregnancy, and previous deep vein thrombosis are recogniz...

GAS CHROMATOGRAPHIC METHOD DEVELOPMENT AND VALIDATION FOR QUANTITATIVE ANALYSIS OF LYSERGIC ACID DIETHYLAMIDE IN ILLICIT PREPARATIONS

The objective of this study was to develop and validate a simple and reliable GC-FID method for quantitative determination of Lysergic acid diethylamide in illicit drug samples. Chromatographic conditions and detection parameters were optimized. Separation was performed on a HP-5...

STABILITY INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION OF ABROCITINIB IN BULK AND TABLET DOSAGE FORM

A simple, precise, accurate and stability-indicating RP-HPLC method was developed and validated for the estimation of Abrocitinib in bulk and pharmaceutical dosage form. The analysis of Abrocitinib in methanol using UV spectrophotometric analysis yielded a well-defined absorption...

AYURVEDIC INTERVENTION IN COMBATING CHEMO-RADIOTHERAPY-INDUCED OTOTOXICITY: A TWO - CASE SHORT COMMUNICATION

Cancer treatment commonly includes surgery, chemotherapy, radiotherapy, or a combination of these modalities. While these approaches have substantially improved survival, many patients continue to experience late adverse effects that affect long-term quality of life. Ototoxicity...

EFFICACY AND MECHANISMS OF PANCHAKARMA IN WOMEN'S HEALTH: A NARRATIVE REVIEW OF POLYCYSTIC OVARY SYNDROME, INFERTILITY, AND MENOPAUSAL DISORDERS

Gynecological and reproductive endocrine disorders, specifically Polycystic Ovary Syndrome (PCOS), female infertility, and menopausal disorders, pose significant global health challenges. Ayurvedic medicine offers systemic therapeutic interventions through Panchakarma (five biopu...

A REVIEW ON PROCESS ANALYTICAL TECHNOLOGY (PAT): APPLICATIONS IN QUALITY ASSURANCE OF PHARMACEUTICAL MANUFACTURING

Conventional pharmaceutical production has largely depended on predefined manufacturing instructions followed by laboratory examination of the finished product. Although this approach can confirm compliance of tested samples, it provides limited information about process behaviou...

A REVIEW ON BULK MANUFACTURING IN THE PHARMACEUTICAL INDUSTRY

Bulk pharmaceutical manufacturing, encompassing both active pharmaceutical ingredients (APIs) and large-scale drug product formulation, forms the foundation of the global healthcare supply chain. This review presents a structured overview of modern bulk manufacturing, including s...

EFFECT OF SUPPLEMENTING CERTAIN ORGANIC ACIDS TO BROILER DIETS ON SOME BLOOD PARAMETERS

An experiment was conducted to study the effect of adding certain organic acids to broiler feed mixtures on blood parameters. The experiment lasted for 40 days, using 150 one-day-old chicks of the (ROSS 308) hybrid, distributed into five treatments. Each treatment contained 30 bi...

DEVELOPMENT AND EVALUATION OF ENTERIC-COATED PANTOPRAZOLE TABLETS FOR ENHANCED GASTRIC PROTECTION

Pantoprazole is a proton pump inhibitor widely used in the management of acid-related gastrointestinal disorders, including gastroesophageal reflux disease, peptic ulcer disease, and Zollinger–Ellison syndrome. Because Pantoprazole is highly unstable in acidic conditions, an ente...

UNDERSTANDING EMOTIONAL ETIOLOGY IN FEMALE REPRODUCTIVE DISORDERS

Ayurveda defines health as equilibrium of Dosha, Dhatu, Agni, Mala, and a balanced Atma, Indriya, and Manas. Manovaha strotas governs psychological and emotional functions. Its strotodushti leads to manasa vikaras like stress, anxiety, grief, and emotional instability. These ment...

PREVALENCE OF DEPRESSION AMONG TYPE II DIABETIC PATIENTS AT IMAM AL-HASAN CENTER IN KARBALA

Introduction: Type 2 diabetes mellitus is a condition marked by a non-autoimmune, heterogeneously progressive loss of sufficient insulin production from islet β cells, often accompanied by metabolic syndrome1 and insulin resistance. Depression is a mood disorder characterized by...