Research works

Sex differences in murine bone matrix maturation modulate osteoblast-endothelial interactions

Abstract Background Bone formation during skeletal growth and repair is divergently modulated by osteoblast-derived vascular endothelial growth factor (VEGF), which contributes to the sexual dimorphism of the bone vasculature. While the extracellular matrix (ECM) provides structu...

Challenges in the Management of Inborn Errors of Metabolism in Low- and Middle-Income Countries

Inborn errors of metabolism (IEMs) are a diverse category of inherited genetic illnesses caused by abnormalities in enzymes, transport proteins, cofactors, or metabolic pathways that lead to disruption of normal biochemical processes. Individual illnesses are rare but collectivel...

Risk-Based Software Test Prioritization via Machine-Learning Defect Prediction: Label-Feature Circularity, Clean Baselines, and an Honest Empirical Study on Five Open-Source Repositories

Risk-based software testing seeks to allocate CI test-execution effort proportional to estimated defect likelihood, typically via a machine-learning classifier trained on repository process metrics. We show that the standard formulation harbours a fatal label-feature circularity:...

Candidate gene identification and molecular marker development for the small granule starch trait in cassava (Manihot esculenta Crantz)

Abstract Cassava ( Manihot esculenta ) is both a vital staple and industrial cash crop, with growing global demand for specialty starches. Small granule cassava starch is highly valued for industrial uses because its reduced size, high amylose content, and improved processing eff...

Recursive Contextual Closure: Longitudinal Loss of Epistemic Permeability in Persistent Human-AI Ecosystems (Position Paper)

Position paper, bilingual: full Hungarian and English texts included, with a supplementary evidence pack (hashed dated note exports, model-analysis annexes, architecture manifest, control-run documentation, claim-revision ledger, CITATION.cff). This paper names and operationalize...

Network Meta-analysis of Safety and Efficacy of Analgesic Transdermal Patches Based on VAS or NRS Pain Scales Across Various Pain Conditions in Non-cancer Patients

Background: Transdermal analgesic systems utilise a prolonged-release mechanism that enhances patient adherence, making them a frequent choice for managing diverse acute and chronic pain states. Nonetheless, robust head-to-head data evaluating their comparative therapeutic value...

The Ostrowski Dimensionless Reformulation: A Systematic Compilation of Fundamental Physics Equations in Planck Units

Version 1.8. Systematic compilation and dimensionless reformulation of 53 fundamental physics equations across ten disciplines, motivated by the Ostrowski Dimensionless Mandate. Dimensional formulations implicitly privilege the Archimedean completion of the rationals per Ostrowsk...

The Regression Trap

Building on Daniel Kahneman’s account of regression to the mean (including his flight-instructor case), Silvan Tomkins’ theory of discrete affect, Donald Nathanson’s Compass of Shame, and recent neurobiological work on the lateral habenula (LHb), the paper traces a mechanism by w...

The Consensus Trap

AI’s growing capacity to synthesize evidence and settle arguments creates an illusion: that settling what is true will also settle what people do. It will not. Behavior is governed by affect — shame, interest, threat, loyalty — not by the truth-value of a conclusion, and no incre...

A Comparative Analysis of Agri-startups in Himalayan and Non-Himalayan States of India

The article examines how challenges encountered by agri-startups operating in the Himalayas differ from those of non-Himalayan states in India. The study employs a mixed-method approach with purposive sampling to collect primary data from 44 Himalayan startups and 107 non-Himalay...

A Neuro-Symbolic Co-Pilot for Autonomous Driving: Post-Hoc Behavioral Discovery for Hierarchical Decision-Making

In the quest for Level 5 autonomous driving, a critical cognitive bottleneck exists between high-frequency mechanical reflexes and low-frequency semantic reasoning. End-to-end Vision-Language-Action (VLA) models provide strong semantic reasoning but introduce inference latency in...

A Nonmonotone Real-Rootedness Set for Symmetric Imaginary Shifts

This AI research artifact presents an exact rational degree-8 polynomial whose symmetric imaginary-shift real-rootedness set is neither an interval nor an up-set. The explicit witness and candidate proof were materially model-generated. Version 0.1.1 changes only artifact classif...

Secure base leadership as an organizational resource in the police training of the Carabineros de Chile

Purpose This study examines how secure base leadership (SBL) exercised by instructors in police academies relates to burnout, work engagement, and cadet performance during training. Drawing on the job demands–resources (JD-R) theory, SBL is conceptualized as an organizational res...

Economic Growth Without Equality? A Marxist Critique of Neoliberalism Development Model

This paper critically examines whether neoliberal development promotes equitable economic growth through the lens of Marxist political economy. Using a qualitative literature-based approach, the study synthesizes classical Marxist theory and contemporary scholarship on neoliberal...

The Ostrowski Dimensionless Reformulation v4.0.4: A Place-Democratic Foundation for Fundamental Physics — Definitive Edition

Version 4.0.4 (PROFESSIONAL MathJax-SVG PDF, 2026-08-02). The mandated single publication workflow replaces pandoc+XeLaTeX entirely. Professional typography: STIX Two Text (embedded, designed for math symbols in prose — zero glyph fallback, no mixed Times/Cambria/Segoe fonts), ST...

Comparison of Clinical Characteristics and Outcomes of Systemic Lupus Erythematosus-associated Thrombotic Thrombocytopenic Purpura and Idiopathic Thrombotic Thrombocytopenic Purpura: A Single Centre Study from Eastern India

Objective: To investigate the clinical characteristics and outcomes of thrombotic thrombocytopenic purpura (TTP) in patients with systemic lupus erythematosus (SLE) compared to idiopathic TTP (I-TTP). Methods: This retrospective cohort study included adult patients with SLE-TTP (...

Household Financial Vulnerability in Kerala, India: A Focus Beyond Debt

Household financial vulnerability is not only about debt; however, research has not yet explored its diverse influencing factors. This study breaks new ground by assessing household financial vulnerability in Kerala, India. The study combines subjective measures with behavioural...

Development of chitosan–sulfonated polystyrene–sulfonated nanosilica nanocomposite proton exchange membranes for direct methanol fuel cells

Abstract In this study, proton exchange membranes (PEMs) based on chitosan (CS), sulfonated polystyrene (SPS), and pristine or modified nanosilica were fabricated for direct methanol fuel cell (DMFC) applications. Membranes containing different SPS contents were prepared, and pol...

Acaricidal activity of silver nanoparticles biosynthesized from unripe fruits of Solanum elaeagnifolium Cav. against Tetranychus urticae Koch

Abstract Background Tetranychus urticae Koch, is a globally significant agricultural pest. Its rapid development of resistance to conventional acaricides poses a major challenge to effective control. Recently, nanotechnology has emerged as a transformative approach in agriculture...

The Habenular Vice

This paper argues shame is not fundamentally social, though it is usually treated that way. Drawing on lateral habenula (LHb) physiology, insular interoception, and the evolutionary history of valence, it makes four claims: shame is precognitive, decided by the LHb before conscio...