Research works

Hierarchical multi-market coordination of virtual power plants via multi-factor differentiated bidding

With the increasing participation of distributed energy resources and the growing importance of carbon and flexibility services, virtual power plants (VPPs) require market bidding and revenue-allocation mechanisms that reflect heterogeneous operating characteristics. Conventional...

Dynamic Degenerate Fiber Bundle Emergent Spacetime Model

This paper proposes the Dynamic Degenerate Fiber Bundle–Emergent Spacetime (DDFB-EST) model as an exploratory framework linking differential geometry, cosmological evolution, biological differentiation, consciousness states, and selected concepts from Daoist internal alchemy. A s...

A Concise Framework for AI-Driven Blockchain: Integrating DRL Consensus and GNN Security Auditing

This research introduces a novel, high-performance hybrid framework merging Deep Reinforcement Learning (DRL) for dynamic consensus optimization with Graph Neural Networks (GNN) for advanced smart contract security auditing. Traditional blockchain architectures frequently struggl...

Understanding students’ perceived source of effort: Bridging effort source belief and effort attribution

Learners’ perceptions of the source of study effort have been increasingly recognised as relevant for understanding how study effort informs judgments of learning (JoLs). This correlational study examined effort source belief (ESB) as a trait-like construct, measured using vignet...

Real-world clinical outcomes of trastuzumab deruxtecan in patients with HER2-low metastatic breast cancer

Trastuzumab deruxtecan (T-DXd) is an antibody-drug conjugate (ADC) approved for HER2-low metastatic breast cancer (mBC), showing improved survival outcomes in clinical trials. However, real-world evidence on its effectiveness among Chinese patients remains limited. Patients with...

Mitochondria-targeted DZ-1-dihydroartemisinin conjugate induces Bax/Bak-independent apoptotic cell death in colorectal carcinoma cells

Artemisinin and its derivatives possess anti-malarial as well as anti-cancer properties against various malignancies. However, their clinical application as anti-cancer agents is limited by several factors, most notably a lack of tumor selectivity. To address this limitation, we...

Insomnia and anxiety exhibit distinct short-term associations following ketamine in treatment-resistant depression

Abstract Insomnia and anxiety frequently co-occur with treatment-resistant depression (TRD). This study examined short-term changes in depression, anxiety, and insomnia symptoms post-ketamine in TRD and their inter-relationships. Seventy-one patients with TRD were assessed at bas...

Simulated Scattering Parameter Dataset for a Randomly Generated Non-Parameterized Microstrip Filter Between 1 and 10 GHz

High-frequency electromagnetic component design is often a complex and computationally expensive task. Analytical techniques are uncommon and frequently yield only approximate solutions. Design processes often necessitate expensive full-wave electromagnetic solvers and iterative...

Pulmonary Proteomic Responses to Subacute 2,2′,5,5′-Tetrachlorobiphenyl-4-ol Exposure via a Subcutaneous Implant in Adolescent Female Rats

Hydroxylated polychlorinated biphenyls (OH-PCBs) are biologically active metabolites that may contribute to adverse respiratory outcomes, yet their effects on the developing lung remain poorly characterized. This study investigated the impact of 2,2′,5,5′-tetrachlorobiphenyl-4-ol...

Preventable in-hospital deaths due to adverse events: a retrospective case record review study

Abstract Background There is no single parameter that describes the level of patient safety in hospitals. Among options, retrospective case record review (RCRR) is an established method for analysing in-hospital deaths to determine the percentage that were preventable. The assess...

Fuzzy-logic enhanced internet of things model for uncertainty-adaptive medical image segmentation

Deep learning (DL) models for brain tumour segmentation (BTS) typically produce a fixed decision boundary and do not allow the uncertainty they estimate to impact the segmentation decision (SD). This work presents a FUZIONet-Med: A Fuzzy Uncertainty-Adaptive IoT Edge Intelligence...

Closing the Gap in Menopause Education

Menopause is a universal experience among women and all those seeking gynecologic care, yet most physicians—including obstetrician–gynecologists—report inadequate training on menopause-related care. As a result, people experiencing menopause often navigate the physical, social, a...

Salivary nanobiosensors for oral diseases: from biomarker discovery to clinical translation in precision dentistry

INTRODUCTION: Current diagnostic approaches to oral disease have limitations, highlighting the need for rapid, sensitive, and accessible technologies for routine clinical use. Biosensors can evaluate a wide range of biomarkers in oral conditions, including periodontal diseases, o...

Percussive Vibration Therapy as an Adjunct to Conventional Physiotherapy in Chronic Non-Specific Low Back Pain: A Randomized Controlled Trial

Background/Objectives: Hand-held percussive vibration therapy (PVT) is widely used in musculoskeletal rehabilitation, yet its incremental benefit beyond an active physiotherapy program for chronic non-specific low back pain (CNLBP) is unclear. We investigated whether PVT added to...

Structural determinants of gender gaps in financial inclusion in Ghana: evidence from Fairlie decomposition analysis

Purpose This study examines what drives gender gaps in financial inclusion in Ghana across four financial services, namely formal accounts, savings, credit and insurance, and tests whether mobile money or structural factors are the primary drivers. Design/methodology/approach A r...

The Genomic Equity Accessibility Framework (GEAF): A dimensionally consistent framework for modeling affordability and equity in genomic and regenerative therapies

Background Advances in CRISPR-based gene editing and stem cell-derived embryo models have created substantial biomedical opportunity alongside significant ethical and distributive concerns. Personalized genomic and regenerative therapies approved in the United States as of this w...

The Origin of Life: A 5-Step Framework from Sulalah to Barzakh - By Muskan Abid (16), Sohdra, Wazirabad

This work presents a 5-step conceptual framework for abiogenesis by 16-year-old independent researcher Muskan Abid from Sohdra, Wazirabad, Pakistan. The model proposes: Sulalah (clay-water gel) to Cosmic Spark (UV), to Core DNA Code, to Kun Compiler, to Barzakh Enclosure. A low-c...

Connecting Human Models Through Human Function: Toward a Common Computational Protocol for Whole-Person Modeling

This preprint proposes human function as a common computational coordinate for connecting heterogeneous models of the same person without replacing their domain-specific meanings. Disease and medical prediction models, physiological and mechanistic models, digital twins, psycholo...

Chemical analysis and effectiveness of essential oils extracted from Citrus sinensis and Citrus tangerina as antioxidants, antibacterial and antileishmanial agents

Citrus peel waste represents an abundant and low-cost source of bioactive essential oils. This study aimed to provide an integrative characterisation of the peel essential oils of sweet orange ( Citrus sinensis ) and tangerine ( Citrus tangerina ), evaluating their chemical compo...

Effects of isolated and combined supplementation of caffeine and capsaicin on a self-paced 10-km running performance

Abstract Purpose To investigate the acute effects of isolated and combined caffeine and capsaicin supplementation on performance and physiological, perceptual, and subjective responses during a self-paced 10-km run. Methods This randomized, double-masked, placebo-controlled cross...