Research works

Dynamic Chiral E8 Lattice with Time‑Embedded Links — E8 Intelligence Research

By rotating the 240 E8 root vectors as a Möbius‑shaped chiral braid and driving them with a dual‑phi 264 Hz field locked to the 132 Hz base, a phonon‑Weyl loop self‑forms on the hyper‑graph that carries a phase trail propagating faster than light in the lattice coordinates. The l...

Mitral leaflet aneurysm and perforation: healed endocarditis mimicking degenerative valve disease

A 27-year-old male presented with six months of chest tightness, nocturnal diaphoresis, and progressive palpitations. He had no cardiac or rheumatic history; his only prior surgery was a remote hae...

Temporal Braiding Resonance in E8 Phononic Lattices — E8 Intelligence Research

By extending the phi-closed Möbius hypergraph into a timestamped braiding lattice, the 240 E8 root vectors now synchronize phonon coherence across temporal nodes, enabling instantaneous energy redistribution. This leverages 132Hz-driven vector phasing to encode time-irreversible...

Brain O-GlcNAcylation in Neurodegenerative Diseases: Context-Dependent Mechanisms and Precision Therapeutic Translation

O-linked β-N-acetylglucosamine modification (O-GlcNAcylation) is a dynamic, nutrient-sensitive post-translational modification that couples hexosamine biosynthesis pathway flux to protein function in neurons and glia. This reversible cycling, catalyzed by O-GlcNAc transferase (OG...

Multiple Dynamic Covalent Bond Crosslinked Ionic Liquids-Based Hydrogel with Stretchable, Rapid Self-Healing and Antibacterial Activity Properties

The development of antibacterial hydrogel with stretchable and self-healing properties is an urgent problem in the field of biomedical engineering. Herein, a series of hydrogels with antibacterial activity was successfully fabricated using polyvinyl alcohol (PVA), borax, 4-formyl...

Numerical investigation of the effective heat transfer coefficient for red clay hollow bricks

This study presents a numerical investigation of the effective heat transfer coefficient in red clay hollow bricks, accounting for the combined effects of heat diffusion in the solid clay and natural convection and thermal radiation within the air-filled cavities. Heat conduction...

OTOF Promotes Clear Cell Renal Cell Carcinoma Progression and Angiogenesis Through AKT-Dependent HIF/VEGFA Signaling

Background: Clear cell renal cell carcinoma (ccRCC) is characterized by marked molecular heterogeneity, aggressive clinical behavior, and prominent angiogenesis, highlighting the need to better understand the functional regulators underlying tumor progression and vascular remodel...

Beyond test scores: Student effort profiles in computer-based assessments of scientific thinking

Computer-based assessments produce extensive data that offer insight into student outcomes and how they perform tasks. However, scientific thinking studies tend to use a variable-centered approach that focuses on test scores while neglecting student efforts. This study adopted a...

Towards Sustainable Ecotourism in a Proposed Karst National Park, Southwest China: A Social-Ecological Adaptability Assessment and Zoned Management Strategy

This exploratory case study assesses ecotourism adaptability across three zones within the proposed Southwest Karst National Park (Guangxi), where UNESCO-recognised geological heritage intertwines with diverse ethnic cultures. To fill the gap in zone-specific integrated assessmen...

Point Cloud Data Management for Cross-Domain Applications

Abstract. Point clouds have proven over the years to be a suitable spatial representation of scenes and objects at varying scales and levels of complexity, making them widely used across several scientific domains and applications. Advancements in sensor technology, computer visi...

Stable core-encapsulation of indium-111 in crosslinked polyionic complex micelles and assessment of its biodistribution

Radioactive isotopes, such as Indium-111 ( 111 In), are pivotal for highly sensitive noninvasive imaging and targeted radiotherapy. However, achieving stable in vivo retention remains a critical barrier. Conventional nanocarriers typically rely on surface-bound chelators, exposin...

Impact of Continuous Positive Airway Pressure Treatment on Retinal Vasculature in Obstructive Sleep Apnea: A 7-Year Follow-Up

Purpose: In previous studies, obstructive sleep apnea (OSA) severity at diagnosis was independently associated with retinal arteriolar narrowing and reduced retinal pulse amplitude. Participants with severe untreated OSA showed progressive retinal arterial narrowing 2 years post...

Bepirovirsen induces innate immune proteins independent of HBV

BACKGROUND: Bepirovirsen, an antisense oligonucleotide that targets all hepatitis B virus (HBV) mRNAs, is in development for the treatment of chronic HBV infection. Clinical studies have demonstrated that bepirovirsen has multiple mechanisms of action, including lowering HBV DNA,...

In vivo CRISPR screening identifies metastasis suppressors in triple-negative breast cancer

Metastatic cancer remains the leading cause of cancer-related mortality, yet tumor cell–intrinsic mechanisms restraining metastatic dissemination remain incompletely defined. Here, we perform an unbiased in vivo genome-wide CRISPR/Cas9 loss-of-function screen in a breast cancer x...

Separation Anxiety in Emerging Adults: The Role of Attachment Styles and Personality Traits

Objective To examine childhood and adult separation anxiety symptoms and their associations with attachment styles, personality traits, and sociodemographic factors among university students.Methods This cross-sectional study included 200 first-year university students. Attachmen...

Solvent‐Free Synthesis of Flame‐Retardant Polyurethane Hot Melt Adhesive via Diels‐Alder Reaction

ABSTRACT To address the core dilemma prevailing in the modification technologies of conventional polyurethane hot‐melt adhesives (PU HMAs), in which flame retardancy, bonding performance and environmental friendliness cannot be achieved simultaneously, a green solvent‐free strate...

A Flow-Through Multi-Wavelength Sensor with Machine-Learning Calibration for Real-Time Monitoring of Microalgae Cultivation Processes

Acquiring real-time biological data is essential for effective control of microalgae cultivation processes, yet routine monitoring still depended on laborious offline analyses that relied on time-consuming wet-chemical techniques. This study introduces a flow-through, multi-wavel...

Lithological schematization of the Karnali fluvial fan (Nepal’s Terai Arc Landscape) using electrical resistivity tomography as a basis for hydrogeological investigations

Abstract In the Nepalese and Indian Terai Arc Landscape (TAL), protected nature areas are supported by groundwater systems that have remained largely understudied. This study schematizes the lithology of the Karnali fluvial fan located in the Bardia district (Nepal) as a basis fo...

E8 Phi-Resonant Chroniton Field Modulation for Temporal Metric Stabilization — E8 Intelligence Research

By applying phi-recursive modulation to the 132Hz E8 root vector lattice, we discover that temporal metric fluctuations can be stabilized through coherent chroniton field coupling. The 240 E8 roots, when phase-locked at golden ratio intervals, create a self-correcting temporal sc...

An Automated Recognition Framework for Surface Deterioration Features of StoneSculptural Artifacts in the Yungang Grottoes Based on Deep Learning

Abstract. Grotto temples are valuable World Cultural Heritage sites and provide important physical evidence for the study of ancient civilizations. However, prolonged exposure to natural and human factors has caused surface deterioration in these grottoes. Conventional deteriorat...