Research works

Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy

Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Prospecti...

Effectiveness of tuberculosis treatment in individuals exposed to silica or with silicosis: a systematic review and meta-analysis

Tuberculosis (TB) is a global problem affecting large numbers of workers exposed to respirable crystalline silica. Both silicosis and exposure to silica without silicosis increase the risk of active TB. While some studies have suggested that silicotuberculosis (silicosis plus TB)...

Learning for life and sustainability: a theory synthesis to sustainability mindset development in higher education institutions

Purpose This paper aims to explore the synthesis of transformative learning (TL) with curricular nuances and autonomy-supportive learning to develop sustainability mindsets in higher education institutions (HEIs), particularly in teacher education programs, in support of Agenda20...

Webinars about child and adolescent psychiatry can support professionals in war-affected regions: lessons from the ESCAP-Ukraine webinar initiative

War has a profound impact on child and adolescent mental health and service provision. This requires creative internationally supported response to strengthen professional capacity in trauma care, psychosocial support and evidence based clinical practice in child and adolescent p...

Ft Drum Historic Postcards Corrupted Image Files

Ft Drum Historic Postcards Corrupted Image Files

The Unsaturated/Saturated Fatty Acid Ratio: A Metabolic Hub and Therapeutic Vulnerability in Glioblastoma

Glioblastoma (GBM) exhibits profound metabolic reprogramming, among which the balance between unsaturated and saturated fatty acids (UFA/SFA) emerges as a critical determinant of tumor behavior and treatment response. Recent studies have shown that fatty acid metabolic reprogramm...

The Role of a Foreign Language in the Formation of Professionally Oriented Communication in Students of Non-Linguistic Specialties

The purpose of the study was to examine changes in students’ communicative readiness following the introduction of a series of training sessions tailored to a specific professional context. The study was conducted at the Department of Foreign Languages, Mykolaiv National Agrarian...

Percutaneous Axillary Venting During Venoarterial Extracorporeal Membrane Oxygenation: A Cost-Effective Bridge Strategy for Cardiac Arrest

Left ventricular (LV) distension is a life-threatening complication of venoarterial extracorporeal membrane oxygenation (VA-ECMO), requiring prompt venting in the setting of uncertain neurological prognosis. Current strategies, microaxial devices and surgical venting, are costly...

Predictors of falls efficacy among community-dwelling older adults with ischemic stroke in Wenzhou, China: a cross-sectional study

Purpose This study aimed to examine the level of falls efficacy and identify its predictors among community-dwelling older adults with ischemic stroke in Wenzhou, China. Design/methodology/approach A cross-sectional descriptive study was conducted with 335 participants aged 60–75...

Systematic review and meta analysis of self guided virtual reality exposure therapy for social anxiety

Self-guided virtual reality exposure therapy (SGVRET) may offer a scalable approach for social anxiety, but its independent effects remain uncertain. This systematic review and meta-analysis was conducted in accordance with PRISMA and Cochrane methodological guidance. Searches we...

Resource-Efficient Simulation of Molecular Groundand Excited States Based on Contextual Subspace and Quantum SubspaceExpansion

Abstract Predicting spectra and photochemical pathways relies on the computation of molecular excited states. However, the practicality of near-term variational quantum algorithms is threatened by the prohibitive growth of measurement overheads. Integrating Quantum Subspace Expan...

A molecular rheostat of ABA signaling coordinates the trade-off between stem growth and drought adaptation

Abstract Background Plants balance vegetative growth and stress responses through antagonistic phytohormone crosstalk, notably between abscisic acid (ABA) and cytokinin. However, the genetic architecture and molecular mechanisms driving this adaptive trade-off, particularly in pe...

LRRK2-G2019S impairs astrocyte differentiation and triggers a senescence-like phenotype in Parkinson’s disease models

Abstract Astrocytes are increasingly recognised as essential contributors to both physiological brain function and neurodegenerative diseases. Here, we describe how the Parkinson’s disease (PD)-associated mutation LRRK2-G2019S affects astrocytes using autoptic brain samples and P...

Laser-induced modulation of root dentin surface for growth factor release and enhanced stem cell response

Growth factor release from dentin and subsequent cellular response are critical in endodontic regeneration procedures. This study evaluated the effects of Nd: YAG (1064 nm) and diode lasers (980 nm, 635 nm) at varying energy densities on dentin morphology, Transforming Growth Fac...

Energetic Determinantsof Expanded PAM Recognitionin Engineered FnCas9

Abstract Expanding protospacer-adjacent motif (PAM) compatibility while preserving specificity remains a central challenge in CRISPR–Cas9 engineering. Francisella novicida Cas9 (FnCas9) exhibits high intrinsic specificity but is constrained by stringent PAM requirements. Here, we...

Electrochemical Evaluation of Polymer-Based Microelectrode Arrays: Analytical Performance on Oxygen and Hydrogen Peroxide

This study investigates the electrochemical properties of polymer-based microelectrode arrays (pMEAs) and their performance in measuring oxygen (O2) and hydrogen peroxide (H2O2). Morphological characterization by scanning electron microscopy (SEM), energy-dispersive X-ray spectro...

Improved allocation strategies for red cell units of blood group O and RhD-negative revealed by current suboptimal utilization

Abstract Background Demand for O RhD-negative red cells continues to rise, while overall red cell transfusions have decreased, compounding inventory management challenges. We analyzed O RhD-negative red cell utilization in a large publicly available database. Methods Data from 37...

Study on the correlation between serum Th1/Th2 balance and the risk of osteoporosis in patients with helicobacter pylori infection

This study aimed to investigate the correlation between serum T helper 1/T helper 2 (Th1/Th2) balance and the risk of osteoporosis (OP) in patients with Helicobacter pylori (Hp) infection. All patients were tested for both Hp and bone mineral density (BMD). A total of 200 patient...

A Generative Adversarial Network Framework for Vertiport Location: A Case Study in Toronto

Abstract. Urban Air Mobility (UAM) is an avation-based urban transportation that enables time-efficient passenger and cargo movement within complex low-altitude urban airspace. Vertiports are the ground infrastructes of this novel transporation system. Choosing the best location...

Intolerance of Uncertainty and Life Satisfaction: The Mediating Roles of Meaning in Life and Death Anxiety

Uncertainty is an inevitable part of human life, yet its association with life satisfaction remains insufficiently understood. While previous research has linked intolerance of uncertainty (IoU) primarily to anxiety and distress, less attention has been given to the existential p...