Research works

Unified Physical-Layer Architecture for Next-Generation AGI and Quantum Infrastructure: Integrating Room-Temperature Coherence, Deterministic Interlocks, and Telecommunications Defense

Abstract: The exponential expansion of Artificial General Intelligence (AGI) and scalable quantum computing has precipitated a systemic, tri-fold crisis: thermodynamic and cryogenic limits in compute substrates, autonomous governance failures in emergent agentic systems, and stru...

Temporally Validated Models for Target “Tclin-likeness”

Abstract Identifying which human proteins are likely to become validated drug targets remains a challenge in drug discovery. We build on the “Tclin” concept, which encompasses proteins for which at least one approved drug exerts its mode of action (MoA); these comprise only ∼3% o...

Paleolithic Somatic Anthropology and Biophysical Architecture of Sensory-Defense: Optical Adaptation of Amber Irises in Ancient East-Eurasian Lineages and Evolutionary Origins of Reactive Interlocks

Abstract Contemporary cognitive engineering, autonomous robotics, and biometric surveillance paradigms operate under the chronic delusion that perception and defensive action must be perpetually predictive, computationally intensive, and software-mediated. This monograph establis...

Modelling plant disease spread via high-resolution human mobility networks

Abstract Human mobility plays a crucial role in the spread of human diseases but is rarely quantified in plant disease epidemics. To address this gap, we integrate a unique, high-resolution network of human movements in New Zealand with a metapopulation model to mechanistically s...

Nonlinear longitudinal stress coupling in glacier and ice sheet flow

Abstract The Greenland and Antarctic ice sheets exhibit high variability in flow speed, over multiple orders of magnitude. This flow integrates forcings from complex, multi-scale and spatially heterogeneous pressure gradient and friction fields into smooth and continuous flow fie...

How brain pulsations drive solute transport in the cranial subarachnoid space: insights from a toy model

Abstract Cerebrospinal fluid (CSF) circulates around and through the brain, supporting neural homeostasis by regulating the extracellular chemical environment. Yet, the physical mechanisms governing CSF-driven solute transport remain poorly understood, limiting the design of diag...

DP-BHIA: A Decoupled-Periapsis Bifurcated Hyperbolic Intercept Architecture for Planetary Atmospheric Sample Return

Direct physical sample return from extraterrestrial atmospheres remains an unexecuted frontier in deep-space exploration, in part because conventional planetary orbit insertion (POI) and dedicated multi-stage rocket ascent from deep gravity wells can impose substantial propellant...

Antibiotic Choice for Community-Acquired Pneumonia in Children With Medical Complexity

BACKGROUND There are no guideline recommendations for antibiotic choice for community-acquired pneumonia (CAP) in children with medical complexity (CMC). We compared broad- vs narrow-spectrum antibiotics in CMC hospitalized with nonsevere CAP. METHODS This cohort study was conduc...

Evolutionary patterns and adaptive strategies of deep-sea anemones

Genome and transcriptome sequencing data of deep-sea anemones.

The impact of health education intervention on knowledge, attitude, and practice of office workers about office ergonomics: a randomized controlled trial

Abstract Background Ergonomics is fundamental to improving safety and efficiency in offices. Therefore, the purpose of this study was to assess the effect of a health education intervention on office workers’ knowledge, attitude, and practice (KAP) regarding ergonomics and to det...

A dental dilemma: bear teeth reveal a spatial gradient in age of primiparity, but temporal trends muddled when bears grew fast

Abstract Age of primiparity (AOP) in American black bears (Ursus americanus) is driven by nutrition. We estimated AOP from patterns of cementum annuli in female bear teeth (more than 16 000), which were collected from hunters in Minnesota, USA, over five decades. AOP was delayed...

Spatial genetic structure of Scots pine (Pinus sylvestris) in Germany- results from the 4th German National Forest Inventory

Abstract In the course of the 4th German National Forest Inventory about 5,000 samples of Scots pine have been collected all over Germany. Analysis of 21 mitochondrial SNP markers on the collected samples allowed the detection of a clear spatial genetic structure separating North...

Do participant testimony videos make people more interested in taking part in a clinical trial? A randomised Study Within a Trial (SWAT), registration SWAT203

Abstract Background Potentially eligible participants do not always agree to take part in trials when approached, which makes recruitment more challenging, time-consuming, and costly. We conducted a Study Within a Trial (SWAT) to evaluate whether showing people brief video testim...

Digital health capacity building across health workforce and education sector in the WHO European region

Abstract Disparities in digital capacity building across countries highlight the need for global upskilling. This study examined digital health capacity building across policy, workforce, and pre-service education domains across 53 countries of the WHO Europe Region. This was a c...

Bite mechanics within the wolf lineage: feeding capabilities of Canis borjgali and Canis mosbachensis inferred by digital bite simulation

Abstract Genus Canis species plays a key role as predator in terrestrial ecosystems. However, the evolutionary history of these carnivorans is still not fully understood. To explore this topic, we studied the bite of two fossil close relatives of the modern grey wolf, Canis borjg...

Serological and transcriptomic response of African fruit bats to immune challenge with recombinant vaccines expressing Ebola or Nipah virus antigens

Abstract Bats are hosts to diverse zoonotic viruses which can cause high case fatality rates in humans. Since detecting viruses in bats is difficult, antibodies are often used for surveillance, though their significance remains unclear in the absence of in vivo immunological stud...

Developmental divergence in gene regulation underlies trophic innovation in Lake Victoria cichlids

Abstract The role of developmental shifts in the emergence of ecological diversity during adaptive radiation remains largely uncharacterized. Here, we investigate the developmental gene regulatory landscape of trophic innovation in the rapid adaptive radiation of cichlid fishes f...

Season-dependent phenological responses and implications for co-occurring plants and butterflies under climate anomalies and extreme weather events

Abstract Despite extensive work on climate-driven phenological shifts, research has focused primarily on early-season events, single metrics and gradual shifts in mean climate, limiting insights into phenological responses across the full annual cycle. Using a 17-year dataset (20...

Ecological responses of soil bacteria to rapid and slow temperature fluctuations

Abstract Fluctuating temperatures profoundly affect microorganisms’ coexistence, biogeographic distributions and responses to future climate change. However, how microorganisms respond to fluctuating temperatures with different frequencies in natural communities remains unknown....

Competing methods of divergence time estimation recover diverse evolutionary timescales

Abstract Molecular clocks convert evolutionary distances into geological times to infer time-scaled phylogenies. Methods differ in terms of fossil calibration strategy (node versus tip) and whether they use molecular and/or morphological data, but their relative performance remai...