Research works

The Second Renaissance: Why System and Complexity Science Is the "Metascience of Metasciences"

Modern science was established upon the "vertical specialization" of Cartesian and Newtonian reductionism, achieving immense local success in micro-isolated slices. However, when confronted with strongly coupled Open Complex Giant Systems (OCGS), reductionism universally traps it...

Shenling Qige Granules inhibit esophageal squamous cell carcinoma progression in TE-1 xenograft and cell-based models by modulating the DCN–TGF-β/Smad signaling axis

Shenling Qige Granules (SLQG), derived from the Qing Dynasty formula Qige San recorded in Yi Xue Xin Wu , has been used in clinical practice in China as an adjuvant traditional Chinese medicine preparation for esophageal squamous cell carcinoma (ESCC), but its molecular basis rem...

Fixed‐Time Disturbance Attenuation Formation Control for Nonholonomic Mobile Robots With Uncertain Sliding

ABSTRACT In this article, a fixed‐time formation control strategy that combines curvature tracking method is proposed for multiple nonholonomic mobile robots with uncertain sliding. Considering the skidding and slipping, a curvature tracking motion law is derived by sorting out t...

Preclinical Evaluation of 68Ga-Labeled Heterodimers for Dual Integrin αvβ3 and PARP1-Targeted Tumor Imaging

Abstract Tumor heterogeneity limits the diagnostic performance of molecular imaging probes targeting a single biomarker. Here, we report the design, synthesis, and preclinical evaluation of 68Ga-labelled heterodimeric radiotracers co-targeting integrin αvβ3 and poly(ADP-ribose) p...

In the nodule or on the nodule? The hidden Frankia biodiversity in Casuarina nodules across continents

Abstract Background and Aims Actinorhizal root nodule symbioses are formed between a diverse group of mostly woody dicotyledonous plants and nitrogen-fixing soil Actinomycetota of the genus Frankia . Some of the most ecologically relevant actinorhizal plants are Casuarina species...

Improving Community-Based Pediatric Health Care Professionals’ Confidence in Providing Suicide Prevention Services

OBJECTIVE: Community-based health care has a vital role in identifying youths at risk for suicide, providing initial interventions, and connecting patients to appropriate services. This study aimed to evaluate the reach and effectiveness of a youth suicide prevention training ser...

User Experiences With a Social Robot for Cardiometabolic Risk Assessment in a Community Setting in Uppsala, Sweden: Qualitative Semistructured Interview Study

Abstract Background Cardiometabolic diseases (CMDs) are a major health concern worldwide, with people living in socioeconomically disadvantaged areas being disproportionately affected. Knowing one’s risk status for developing a CMD can help individuals in delaying or preventing t...

Rainfall homogeneity, variability, and trends across unimodal and bimodal regimes in the Wami Basin, Tanzania

ABSTRACT The graphical abstract links rainfall data, statistical tests, spatial outputs, and hydrological implications for the Wami basin. Rainfall regime coexistence influences hydrological variability in semi-arid regions, but is rarely treated explicitly in basin-scale assessm...

Marginalization of Maltreatment of Family Caregivers of Older People in Sub-Saharan Africa: An Epistemic Injustice?

This theoretical paper interrogates aging and caregiving, focusing on the abuse of caregivers of older people in Sub-Saharan Africa, through the lenses of Epistemic Injustice, Social Identity, and Feminist Theories. Epistemic Injustice shows how societal structures silence caregi...

Sharp exponential edge bounds and flag constructions for multipartite intersecting hypergraphs

We construct strictly t-intersecting r-partite r-uniform hypergraphs with fixed ratio r/t = 3 and arbitrarily large vertex cover number, answering Problem 1 of Bishnoi, Das, Morris and Szabo. The construction attains a sharp universal edge bound: every finite, nonempty, simple hy...

Decoding cold tolerance in chilli: An integrated assessment of morphological, physiological, biochemical, and molecular responses

This study evaluated multifaceted cold tolerance mechanism in twelve hot pepper genotypes by assessing morphological, physiological, biochemical, and molecular responses associated with cold stress resilience. Considerable genotypic variation was observed across all evaluated par...

Successful treatment of achalasia in the context of Allgrove syndrome using peroral endoscopic myotomy in siblings: a clinical case

Objective. To present current evidence on Allgrove syndrome and to review diagnostic and therapeutic approaches to achalasia associated with this condition based on a clinical case. Key points. Allgrove syndrome (Triple-A syndrome) is a rare autosomal recessive genetic disorder c...

Not simply a decline: gendered changes in students’ intrinsic motivation towards mathematics

Abstract This study examines one-year changes in students’ intrinsic motivational orientation towards mathematics and whether these changes are gendered. Drawing on Swedish data from the TIMSS 2023 Longitudinal Study, we analysed two student cohorts, followed from Grade 4 to Grad...

Molecular Docking-Based Screening of Epicatechin Gallate against Estrogen Receptor 1 (ESR1) Using Estradiol as a Standard Ligand: Insights into Female Reproductive Health

Female fertility and ovarian function are controlled by a complex network of hormonal signals, in which estrogen receptors play an important regulatory role. Among these receptors, estrogen receptor 1 (ESR1) is widely expressed in ovarian tissues and contributes to essential repr...

Simulating Methane (CH4) Transport Pathways from a Rice Crop Grown on a Degraded Fen Peat Soil using the Peatland-VU Model

Important notes for future model users that seek to simulate the Peatland-VU model The modelling data uploaded in the zipped folder called as "Swiss PeatVU Aug2026 outputs" contains the simulations conducted using the Peatland-VU model. These Peatland-VU simulations are for the s...

Genomic determinants of penicillin G susceptibility and cefazolin inoculum effect in methicillin-susceptible Staphylococcus aureus bloodstream isolates.

BACKGROUND: This study aimed to describe penicillin G susceptibility, blaZ diversity, and genetic determinants of the cefazolin inoculum effect (CfzIE) among MSSA bloodstream isolates. METHODS: The first three non-duplicate MSSA isolates recovered each month from blood cultures a...

Towards sustainable 3D concrete printing: influence of waste foundry sand on rheology and printability of OPC–LC2 systems

Concrete demand depletes natural resources and increases CO2 emissions; simultaneously, industrial waste causes land pollution. Using waste foundry sand (FS) and low-carbon limestone calcined clay (LC2) offers a sustainable solution to these challenges. In this study, quartz sand...

SOFA-2 vs. SOFA and early warning scores for short-term mortality in older adults with sepsis in the emergency department

SOFA-2 was developed to update the SOFA score for contemporary clinical practice, but its performance in older adult emergency department (ED) patients with sepsis is uncertain. We evaluated SOFA-2 for short-term mortality prediction and compared it with SOFA and commonly used ea...

Framing the future: how disruptive events reshape material preferences in global residential construction

Purpose Disruptive events, such as natural disasters and pandemics, can considerably reshape home buyers’ preferences in the residential construction industry. These shifts are evident in changing preferences of building materials in response to sustainability, resilience, cost a...

Entity-centric evaluation of large language model responses for medical question-answering tasks

Large language models (LLMs) are increasingly evaluated for clinical question-answering (QA) tasks, yet benchmark accuracy alone provides limited assurance of clinical reliability. Existing evaluation metrics often fail to capture whether model reasoning preserves patient-specifi...