Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
125045 work(s)
- Biology
Abstract Teriparatide, the only FDA-approved osteoanabolic drug for osteoporosis, suffers from poor metabolic stability and requires frequent subcutaneous injections, leading to suboptimal patient compliance. To find optimized teriparatide derivatives, we herein report an iterati...
- Climate & Environment
Abstract Natural gas hydrates naturally occur in pores of porous media. This study presents the first systematic investigation of methane hydrate formation in sub‐millimetre silica particles (0.4 and 0.7 mm) and larger sizes (1, 2, and 3 mm) as benchmarks. The combined matrix (0....
- AI & ComputingOpen access
Seq2Pocket: Augmenting protein language models for spatially consistent binding site prediction
Abstract Motivation Protein-ligand binding site prediction (LBS) is important for many areas of structural biology and molecular modeling, where, as in other tasks, protein language models (pLMs) have shown great promise. In their application to LBS, the pLM classifies each amino...
- Materials & EnergyOpen access
Abstract This work reports a comprehensive investigation of the structural, morphological, and local-scale evolution of molybdenum oxides (MoOx) derived from a chelated precursor obtained via thermal decomposition of molybdenum(II) acetate. By systematically controlling annealing...
- Engineering & TechnologyOpen access
Galerkin error reduction and eigenvalue localisation for conforming FEM
Abstract The reduction factor $$\varrho $$ ϱ in a Galerkin scheme with conforming $$P_1$$ P 1 finite element spaces on simplicial meshes is the maximal quotient of the Galerkin errors in the $$L^2$$ L 2 norm divided by the energy norm (the $$H^1$$ H 1 semi-norm) for the Poisson m...
- Materials & Energy
Abstract Converting simple hydrocarbon feedstocks into stereochemically complex molecules remains a central goal of synthetic chemistry. α-Tetrasubstituted amino acids, which feature densely substituted stereogenic centers and important applications in chemical biology and medici...
- Physics & SpaceOpen access
Measurements of the spin correlation coefficients in the beam basis are presented for top quark-antiquark (𝑡$\overline{𝑡}$) systems produced in proton-proton collisions at √𝑠 =13 TeV collected by the CMS experiment in 2016–2018, and corresponding to an integrated luminosity of 1...
- Health & MedicineOpen access
Abstract Background Accurate biomechanical alignment is crucial for the success of Total Hip Arthroplasty (THA). Obesity poses an increasing challenge in THA. This study compares hip restoration and clinical outcomes after direct anterior approach (DAA) THA between non-obese and...
- Physics & SpaceOpen access
TMF ↔ GR/QM: A Correspondence Map (Working Document v0.2)
This document establishes the opening stage of the Temporal Measure Framework (TMF) empirical and formal programme. It demonstrates that TMF can reinterpret key results of General Relativity (GR) and Quantum Mechanics (QM) without invoking coordinate singularities, and provides a...
- Health & Medicine
Abstract Endoscopic ultrasound-guided liver biopsy (EUS-LB) is increasingly used for hepatic histologic assessment; however, optimal technical approaches remain undefined. This prospective, multicenter clinical study aimed to compare tissue acquisition and safety between the rapi...
- Climate & EnvironmentOpen access
Dry dipterocarp forest (DDF) in mainland Southeast Asia burns frequently in surface fires, yet the vertical fuel strata observable from airborne and spaceborne sensors remain uncertain. We compared handheld SLAM LiDAR, UAV LiDAR, GEDI, ICESat-2, PlanetScope, and Sentinel-1/2 at S...
- Health & MedicineOpen access
Armed conflict severely disrupts cancer care, particularly in low- and middle-income countries with fragile health systems. Since April 2023, the war in Sudan has crippled oncology services, yet empirical evidence on its impact on cancer patients remains scarce. Therefore, this s...
- BiologyOpen access
Crop plants are continuously exposed to adverse environmental conditions, among which soil salinity is one of the major factors limiting plant growth and productivity. One approach to mitigating the detrimental effects of salt stress is the application of osmoprotectants such as...
- Society & EconomicsOpen access
Abstract This paper tells the story of Felipe Pescador, a neighbourhood born of an occupation of railway lands by railway employees in Mexico City’s industrial corridor. Across disciplines, a rich literature on Latin America has critically examined housing struggles among margina...
- Health & Medicine
STAT3 operates as an inflammation-dependent transcriptional switch in antiviral NK cells
The immune system integrates signals to regulate immune responses, forming complex context-dependent networks where identical cues produce distinct outcomes. Signal transducer and activator of transcription (STAT) transcription factors convert cytokine receptor engagement into tr...
- Materials & EnergyOpen access
Transition metal sulfides and oxides are attractive for supercapacitor electrodes due to rich redox sites and high theoretical capacitances. Yet single-phase materials suffer from poor structural stability and slow charge transfer, restricting practical applications. Herein, a fa...
- BiologyOpen access
CRISPR/Cas9 induced disruption of oca2 and tyr genes associated with pigmentation in Danio rerio
Targeted disruption of genes has been successfully carried out in several model and non-model fish species. In ornamental fish industries, Danio rerio (D. rerio) represents the most significant fish species and is available in several color varieties. Recently, CRISPR/Cas9 has be...
- Health & Medicine
Abstract Safe, small-molecule prophylactic agents against respiratory syncytial virus (RSV) are critically lacking. Here, we identify Cynarin, an artichoke-derived dietary polyphenol, as a micromolar affinity CX3CR1 antagonist. Mechanistically, Cynarin confers dual-action protect...
- Society & EconomicsOpen access
Religious moderation education has become a global concern as plural societies confront intolerance, polarization, and digital extremism. Indonesia is a relevant locus because its Islamic educational institutions operate within diverse religious, cultural, and ethnic settings. Ho...
- Engineering & TechnologyOpen access
Existing learning-based AFP inspection methods predominantly rely on grayscale/depth-like representations or directly learned appearance features, while the directional relationship between laser-profile height variation and defect boundaries remains insufficiently exploited. Thi...