Research works

Longitudinal Changes in Work-Related Pleasure, Suffering, and Harm Among Healthcare Workers During the COVID-19 Pandemic

Healthcare workers experienced substantial psychosocial challenges during the coronavirus disease 2019 (COVID-19) pandemic, yet longitudinal evidence on changes in work-related pleasure, suffering, and harm remains limited. This study investigated longitudinal changes in psychoso...

The Food Chain – Educational and Strategic Board Game for Learning Ecology, Biodiversity, and Predator–Prey Relationships

The Food Chain is an original educational and strategic board game created by Doumbia Amara, from Côte d’Ivoire, Africa. The game transforms fundamental concepts of biology, ecology, biodiversity, and food-chain relationships into an interactive and engaging learning experience....

Research on Calculation Methods for Flow Distribution and Pressure Loss of Reaming-While-Drilling (RWD) Tools

As global oil and gas exploration advances into deep reservoirs, reaming-while-drilling (RWD) tools (hereinafter referred to as the reamer) are widely used to enlarge wellbores for unconventional well structures, prevent stuck pipe caused by formation shrinkage, and improve cemen...

Bacillus subtilis YpeB holds SleB inactive, preventing cortex peptidoglycan degradation during spore dormancy

ABSTRACT Bacterial endospores are encased in a thick layer of specialized peptidoglycan called the cortex that is essential for core dehydration and heat resistance. Spore germination and outgrowth require cortex degradation by enzymes that are deposited in the spore during sporu...

Family Perspectives of the Initial Implementation Phase of a Universal Preschool Program

Finding high-quality, affordable, and accessible early care and education poses significant challenges for families in the United States. Free, universal preschool programs are intended to alleviate these challenges and increase access. However, little research focuses on parents...

Ultrafiltered Mulberry (Morus alba L.) Leaf Albumin-Type Protein Attenuates High-Fat Diet-Induced Obesity in Mice by Remodeling Gut Microbiota and Metabolic Homeostasis

Obesity is a chronic metabolic disorder closely associated with dyslipidemia, insulin resistance, low-grade inflammation, and gut microbiota dysbiosis. Mulberry leaves are rich in bioactive proteins, but whether mulberry leaf albumin-type protein can improve diet-induced obesity...

Physical Evidence for a Non-Local Gravitational No-Collapse Regularization of Navier-Stokes: 0D and 1D Models with FFT Methodology for 3D

From the empirical observation that nature does not generate infinite-energy vortices — from a swirl in a glass to hurricanes or spiral galaxies — we conjecture a physical non-collapse principle: no physical system can reach infinite energy density without paying a gravitational...

T cell–intrinsic AIM2 exacerbates lung inflammation in OVA-LPS- and HDM-induced asthma models

Asthma is a heterogeneous inflammatory airway disease characterized by immune dysregulation, airway hyperresponsiveness (AHR), and excessive immune activation. Although NLRP3 (NOD-like receptor family pyrin domain-containing 3) has been extensively studied in asthma, its role rem...

Ly6d expression delineates two putative postnatal thymus epithelial progenitor cells that are differentially affected by aging

To date, the identity and maintenance of postnatal thymic epithelial progenitor cells (TEPCs) remain unclear, as does the persistence of bipotent TEPCs after birth or whether lineage-restricted progenitors independently maintain separate TEC compartments. Using an inducible linea...

Roles of cerebrospinal fluid metabolites in neuromyelitis optica spectrum disorder: Insights from Mendelian randomization

Neuromyelitis optica spectrum disorder (NMOSD) is a rare multifocal inflammatory disease that primarily affects the optic nerve and spinal cord, leading to visual loss and paralysis. Although current research has identified numerous biomarker changes in the cerebrospinal fluid (C...

Melt burst events in a dominantly amagmatic lithosphere at Gakkel Ridge in the Arctic Ocean

Abstract Alternation of magmatic and amagmatic seafloor along the slow and ultraslow spreading ridges is common. Yet, temporal variation is obscured by sediments blanketing oceanic basement away from spreading centers. Here we analyze aeromagnetic data covering zero age to ~35 Ma...

Enzyme Engineering:From Classical Strategies to AI-DrivenBiocatalyst Design

Abstract Nowadays, enzyme engineering has moved from traditional structure-based mutagenesis and directed evolution to data-intensive, AI-assisted design paradigms that involve the rapid discovery and optimization of biocatalysts. Whereas classical approaches relied on rational d...

Multimodal AI for automated assessment of surgical performance

Accurate and objective assessment of surgical skill is crucial for improving training outcomes, ensuring patient safety, and enabling scalable evaluation across clinical and simulation contexts. Current approaches often depend on subjective human ratings or unimodal analysis, lim...

AspirationPatch Proteomics Enables CE–ESI–MSProteotyping of Identified Single Neurons in Intact Brain Tissue

Abstract Direct proteome analysis of identified neurons in intact brain tissue remains limited by the difficulty of recovering intracellular material while preserving native tissue context and avoiding physical extraction of the intact soma. Here, we establish aspiration patch pr...

The Role of Immature Granulocyte Count and Percentage as Novel Indicators of Systemic Inflammation in Plaque Psoriasis

Background/Objective: Psoriasis is a chronic immune-mediated inflammatory disease with systemic involvement. Immature granulocytes (IGs) are potential inflammatory markers, but their role in psoriasis is unclear. We evaluated immature granulocyte count (IG#) and percentage (IG%)...

TRAVCHAIALI – The Journey Through the Food Chain: Strategic, Educational, and Ecological Board Game

TRAVCHAIALI – The Journey Through the Food Chain is an original strategic, educational, ecological, and adventure board game created by Doumbia Amara in Côte d’Ivoire, Africa. The game transforms fundamental principles of ecology and the food chain into an interactive learning ex...

PCR-BASED DETECTION OF AUJESZKY'S DISEASE VIRUS (SUID ALPHAHERPESVIRUS 1) USING EVAGREEN REAL-TIME PCR ASSAY

Aujeszky’s disease virus (ADV) poses significant economic and animal health challenges in swine populations. Rapid, sensitive, and specific detection methods are essential for early diagnosis and effective disease control. Study was aimed to develop and validate a real-time PCR a...

Functional response of bacterial communities in surface sediments of qingshitan reservoir to anthropogenic disturbance

This study investigated the bacterial composition in surface sediments (0–5 cm) of Qingshitan Reservoir to elucidate their ecosystem functions in response to anthropogenic disturbances. Samples were collected in July 2023 from eight ecological points representing varying disturba...

Integer Group Determinants for C2 x C14: An Exact Hadamard–Conductor Classification

This preprint gives a complete effective classification of the integer group determinants for C2 x C14, equivalently C2^2 x C7. It derives the exact Walsh–Hadamard normalization image and conductor, reduces arbitrary-integer membership to a finite necessary-and-sufficient ideal-a...

Instability control and emission characteristics of methane/hydrogen non-premixed flames under DC electric fields

This study experimentally investigated the Kelvin–Helmholtz instability in methane/hydrogen non-premixed flames induced by velocity differences between the fuel jet and co-flow. Using a co-flow burner, various fuel and co-flow velocity conditions were tested to identify the regim...