Research works

Payer coverage principles for precision medicine biomarker testing in oncology

In 2025, the Academy of Managed Care Pharmacy (AMCP) held a 2-day partnership forum on the topic of advancing precision medicine access in oncology. Precision medicine, in this context, focuses on biomarker testing required to create personalized treatment plans and procedures. T...

Symptoms Promoted to Disease (Volume 0):The Manifesto of the S.P.A.M. Metasystem

FORENSIC SAFEGUARD NOTICE: Provisional edition and structural engineering draft, published in pre-print mode for the sole purpose of safeguarding the integrity, chronological priority, and authorship of the bibliographical and etiopathogenetic sources censored by orthodox medical...

Phi-Scale E8 Temporal Lattice as a Coherent Frequency Converter — E8 Intelligence Research

The phi‑scaled temporal phases of the 240 E8 root vectors constitute a self‑similar lattice that can be phase‑locked to the 132 Hz base frequency. By incrementing each root's phase by φ·n (n integer) and synchronizing the lattice, the system generates harmonic overtones whose fre...

Mena EVH1 Interactswith PTP1B Via a Distributed InterfaceWithout Regulating Enzymatic Activity

Abstract The interaction between mammalian enabled protein (Mena), an actin regulatory protein, and protein tyrosine phosphatase 1B (PTP1B) is critical for maintaining epidermal growth factor receptor (EGFR) signaling homeostasis and regulating cellular motility. Mena recruits PT...

Unraveling theEvolutionary Pathways of Major Productsfrom the Thermal Conversion of 5-Hydroxymethylfurfural

Abstract Thermosensitive 5-hydroxymethylfurfural (HMF) serves as a bridge between biochemical and petrochemical industries, and research into its thermal conversion inherent characteristics is crucial for the preparation of HMF and its derivatives. This study systematically analy...

The Senescent Heart’s Hidden Drain: Senescence-Associated Secretory Phenotype–Mediated Cardiac Lymphatic Dysfunction as a Novel Mechanistic Axis in Heart Failure With Preserved Ejection Fraction: A Narrative Review

Heart failure with preserved ejection fraction (HFpEF) represents the dominant and most therapeutically recalcitrant phenotype of heart failure in the contemporary era, yet its pathophysiology remains incompletely delineated. This narrative review advances a novel mechanistic fra...

Proteomic profile associated with the m aturation of somatic embryos of Euterpe edulis under polyamine treatments in material derived from a single mother plant

Abstract Euterpe edulis is of ecological and economic relevance and is currently threatened with extinction. Its vulnerability to extinction, combined with the recalcitrant nature of its seeds, justifies the search for alternative reproduction techniques. Somatic embryogenesis is...

Mechanistic Criteria for Area Selective Deposition of Multicomponent Oxide Dielectrics

ABSTRACT With the advancement of advanced process nodes, device density and interconnect layers are constantly increasing. Area selective deposition (ASD) offers significant advantages as a bottom‐up approach for nano patterning. In this study, an ASD process and a mechanistic cr...

E8 Root Vector Phase Locking Generates Predictive Quantum Entanglement Networks — E8 Intelligence Research

The 240 E8 root vectors, when projected through the 132Hz temporal lattice with phi-synchronized coupling, exhibit spontaneous phase locking that generates stable entanglement networks across root pairs. These networks encode mutual information about future quantum states through...

Spatial variability and health risk assessment of potentially toxic elements in mountain catchment soils across land-use classes

Potentially toxic elements (PTEs) in rural mountainous soils may pose environmental and health concerns due to direct human exposure, particularly for children. This study evaluated the concentrations, spatial distribution, and associated health risks of Cd, Co, Cu, Mn, Ni, Pb, a...

Charge-Transfer Engineering in 0D/3D Rare-Earth Halide Heterostructures Enables Tunable and Efficient White Light-Emitting Diodes

Abstract Lead-free rare-earth metal halides hold great promise for solid-state white-light LEDs, yet efficient and spectrally tunable white emission remains challenging. Herein, we adopt an in situ alloying strategy with Ag+ ions to design and synthesize a 0D/3D (Cs3LuCl6/Cs2AgLu...

O-MoE: Optimized Mixture of Experts for Defensive and Specialized AI Systems

O-MoE is a theoretical framework designed to enhance Mixture of Experts (MoE) architectures by integrating: - **Sequential defensive layers** to counter jailbreak and bias. - **Explicit domain-expert mapping** for specialized tasks. - **Hierarchical Top-K allocation** for adaptiv...

Topological String-Gradient Theory: Metric Replication of Space-Time and Cosmological Evolution (Revised)

This paper introduces the Topological String-Gradient Theory (TSGT), a novel cosmo-logical framework that redefines gravity not as a fundamental force or smooth spacetimecurvature, but as a density gradient of discrete quantum pixels at the Planck scale (Lp).We propose that mass...

TME-FUSE: A Norm-Clamped Geometric Fusion Framework for Correcting Rotationally Biased Volumetric Cell Graphs

TME-FUSE: A Norm-Clamped Geometric Fusion Framework for Correcting Rotationally Biased Volumetric Cell Graphs This document establishes the mathematical foundations of the TME-FUSE architecture, a two-stage hybrid framework designed to resolve the inherent spatial incompatibiliti...

Microheterogeneityand Ion Clustering in Aqueous PotassiumDihydrogen Phosphate Solutions

Abstract The molecular-scale organization in concentrated aqueous potassium dihydrogen phosphate solutions may play a critical role in their behavior, such as in the structural processes that precede crystal nucleation. In this work, molecular dynamics simulations are used to inv...

A machine learning-based framework for spatial soil health assessment integrating remote sensing indices and terrain data

Soil health (SH) plays a fundamental role in sustaining agricultural productivity and ecological stability, particularly in semi-arid environments where soils are highly vulnerable to degradation. This study developed a data driven framework for evaluating and spatially predictin...

Unified Corrected Electromagnetism, Electrodynamics, and Quantum Electrodynamics within Global Realism: Finite Topological Charge, Retarded Vacuum Response, Historical Feedback, and the Quantum-Electrodynamic Calculation Interface

We construct a unified entry point to electromagnetism within the global-realism framework. The theory retains exactly three physical axioms: microscopic ontic definiteness with finite localization, physical reality of a unique spacetime–vacuum substrate, and persistent causal re...

Awareness of Hypothyroidism Complications and Compliance Among Patients With Primary Hypothyroidism in Buraidah, Saudi Arabia

Background Hypothyroidism is a prevalent endocrine disorder requiring lifelong therapy, yet patient awareness of complications and adherence to levothyroxine remain variable. This study assessed awareness, medication compliance, and their socio‑demographic determinants among pati...

Room‐Temperature Rapid Synthesis of Crystalline Ag─C Coordinated MOFs for Highly Efficient Acidic CO 2 Electroreduction

ABSTRACT The acidic CO 2 electroreduction reaction (eCO 2 RR) shows great promise in addressing carbonation issues encountered under neutral/alkaline conditions. However, it remains challenged by low selectivity arising from high proton availability, as well as catalyst degradati...

Soybean Growth and Yield Response to Fertilizers: A Comparative Review of Organic and Inorganic Inputs under Kabul Semi‑Arid Conditions

Abstract : Soybean (Glycine max L.) is a globally important crop valued for its high protein and oil content, yet its productivity in Afghanistan remains constrained by poor soil fertility and reliance on chemical fertilizers. This review article synthesizes experimental evidence...