Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
125045 work(s)
- BiologyOpen access
The CARM1–YIPF2 axis drives breast cancer progression and predicts poor prognosis
Objective To investigate the roles of CARM1 and its regulatory effect on YIPF2 in breast cancer progression. Methods Breast cancer cells were transfected with CARM1 siRNA to knock down CARM1 expression. Cell proliferation, apoptosis, migration, and invasion were assessed using Ed...
- Health & MedicineOpen access
Microbiome Targeted Therapies for Primary Sclerosing Cholangitis
Primary sclerosing cholangitis is a rare, progressive cholestatic liver disease of the intrahepatic and extrahepatic bile ducts with poor prognosis. The only life-extending treatment for PSC is liver transplantation, with up to 25% of post-transplant patients developing recurrent...
- Health & MedicineOpen access
BackgroundWhen pancreatic adenocarcinoma is found unresectable during surgery, the decision to perform palliation must balance symptom relief against recovery and subsequent cancer treatment. We compared clinical outcomes after palliative procedures and nontherapeutic exploration...
- BiologyOpen access
The representation of order and randomness in the auditory cortex
Perception fundamentally relies on the brain’s ability to extract structure from its sensory environment. The auditory cortex possesses significant sensitivity to statistical regularities in tone sequences. To examine this phenomenon at the single-neuron level, we used multitone...
- Society & Economics
Purpose This study examines whether the readability of management commentary is associated with analysts' coverage and the precision of analysts' information sets. It further investigates whether analysts' experience, access to resources and forecast boldness moderate these relat...
- Materials & Energy
Abstract Despite their potential as building blocks of allenes, alkynylogous enol silanes have rarely been employed in organic synthesis. Herein, we establish their utility as nucleophiles in catalytic asymmetric allylic substitution, which results in skipped enallenes bearing tw...
- Society & Economics
Informal family care for a child with a mental disorder may negatively impact work capacity and decrease income. We compare prolonged sex-specific personal income progression between informal family caregivers of children/young adults with and without mental disorders. We evaluat...
- Materials & EnergyOpen access
Birefringent crystals are indispensable for optoelectronic applications, yet commercially available crystals still suffer from the drawback of insufficient birefringence. Meanwhile, tetracoordination units—traditionally confined to a tetrahedral geometry—have long been sidelined...
- Health & MedicineOpen access
Periodontitis adversely impacts Oral Health-Related Quality of Life (OHRQoL), but the relative contributions of clinical severity, socioeconomic status (SES), treatment status, and sociodemographic factors remain insufficiently defined. This study aimed to evaluate differences in...
- AI & Computing
Archaeologists often face the complex and time-consuming task of reassembling fragments from broken artifacts. Fragment reassembly is traditionally done manually by domain experts. Automatic algorithms have advanced but are typically tailored to specific fragment types, often ass...
- Physics & SpaceOpen access
Periodic optical variability of the known white dwarf WD J2101+2935
A research note reporting periodic optical variability of the known DC white dwarf WD J2101+2935 (Gaia DR3 1846405001739893376). Original ZTF photometry and independently acquired Pan-STARRS images support a preferred photometric repetition period of approximately 71.3153 minutes...
- Health & MedicineOpen access
Abstract Pathological cardiac hypertrophy presents a important public health challenge, particularly in aging populations, highlighting the urgent need for novel therapeutic targets. This study investigates the role and molecular mechanisms of OTUD5 in pathological cardiac hypert...
- Society & EconomicsOpen access
AI companion chatbots support extended personal conversations, and many adolescents use them for companionship and emotional support. Two American lawsuits allege that prolonged interactions with these systems contributed to minors’ suicides. In 2025, California, New York and Uta...
- Health & MedicineOpen access
Background/Objectives: Bariatric–metabolic surgery (BMS) improves obesity through neuroendocrine mechanisms involving bile acids (BAs) and nutrient-stimulated gastrointestinal hormones. However, the underlying pathophysiology involved remains poorly understood. BAs are essential...
- Health & Medicine
Background: Intermittent monitoring (IM) of vital signs remains the standard of care for hospitalised ward patients, yet this approach creates gaps during which patient deterioration may go unrecognised. Wearable wireless devices capable of continuously measuring physiological pa...
- Society & Economics
Purpose With the rapid growth of influencer marketing, whether influencer popularity consistently enhances consumer attitudes remains unclear. Drawing on the elaboration likelihood model (ELM), this study adopts a product involvement perspective to examine the effect of influence...
- Health & Medicine
Human to animal care: one nurse's remarkable career change
US‐born Daphne Simpson spent decades caring for people before swapping continents – and then professions – to support animals facing cancer diagnoses at one of the UK's largest referral hospitals.
- Engineering & TechnologyOpen access
The building industry accounts for one-third of global energy consumption and CO2eq emissions, yet research on green certification for public-building renovations remains limited in Southeast Asia. This study prioritizes parameters for achieving Excellence in Design for Greater E...
- Health & MedicineOpen access
Best Practices for Optimizing Recovery from Sepsis; Results of an Expert Panel
Abstract Background Over one million patients survive sepsis annually in the USA. After sepsis, patients often experience new morbidity, with high rates of readmission and post-acute mortality. However, there are limited data to inform best practices to support recovery from seps...
- Health & Medicine
BACKGROUND: Intensive care units (ICUs) are high-risk environments where nurses administer the majority of high-alert medications, making them the final checkpoint in the medication-use process. However, evidence on nurse-led interventions specifically targeting high-alert medica...