Research works

Adaptive Integrated Microfluidic System with Real-Time Dielectric Feedback for Deterministic Micro-Manipulation

Abstract Conventional microfluidic particle sorting systems predominantly rely on static, open-loop operational principles, rendering them highly vulnerable to performance deterioration induced by cellular phenotypic heterogeneity and localized hydrodynamic fluctuations. Here, we...

Lysosomes: a central hub orchestrating metabolic plasticity, signal integration, and proteostasis in adult stem cell quiescence

Abstract The quiescent state of adult stem cells is fundamental to their protection against exogenous damage, the maintenance of stem cell pool stability, and the preservation of long-term regenerative potential in tissues. Elucidating the underlying regulatory mechanisms is of p...

Phage Therapy and Phage-Derived Lytic Proteins in the One Health Era: Mechanisms, Challenges and Emerging Innovations

Antimicrobial resistance is a critical global health threat, as conventional antibiotics are increasingly ineffective against multidrug-resistant (MDR) pathogens, particularly ESKAPE organisms. In response, bacteriophages and their derived lytic proteins, including endolysins, ho...

A Predictive Enrichment Model for Auricular Acupoint Stimulation in Post-Stroke Shoulder-Hand Syndrome: Identifying Baseline Effect Modifiers

Background Auricular acupoint stimulation (AAS) improves upper limb function in poststroke shoulder–hand syndrome (SHS), but treatment response heterogeneity limits personalized application. We aimed to identify baseline effect modifiers that predict differential response to AAS...

EuroMillions Breakthrough Mining — 9783 Sources, 95812 Leads Extracted — E8 Intelligence Research

Mined 9783 lottery+quantum breakthroughs. Extracted 95812 leads across 13 categories. 92446 high-value leads found. Categories: {"CORRIDOR": 8374, "FORMULA": 8174, "GEOMETRIC": 1534, "FORWARD_ATTEMPT": 8764, "QUANTUM": 9019, "TIMING": 564, "CELESTIAL": 8240, "GEMATRIA": 8571, "CO...

A Novel Umami Peptide Selector (UPS) for Identifying Key Peptides from Maillard-Reacted Chicken Hydrolyzates: From Taste Evaluation to Antioxidant Properties

Abstract The Maillard reaction (MR) enhances the flavor of chicken enzymatic hydrolyzates, yet pinpointing key umami peptides remains challenging due to complex matrices. Sensory evaluation showed increased umami intensity despite decreased equivalent umami concentration (EUC: 0....

The Geometry of Bitcoin: Superlinear Feedback and the Finite-Time Singularity Problem

Self-reinforcing feedback appears across disciplines, and where it is superlinear it produces not unbounded growth but a finite-time singularity. The classical treatment assumes a fixed feedback exponent: for dy/dx = k(1 + ym), a singularity occurs if and only if m > 1, at the di...

Comparison of transbrachial and transfemoral venous access in varicocele embolization: impact on radiation dose and technical success

Abstract Objectives This study evaluates the advantages of superficial venous transbrachial access compared to conventional transfemoral access in varicocele embolization, focusing on technical success and radiation dose reduction. Materials and methods A retrospective analysis w...

Evaluation of factors that delay initial epinephrine administration in patients with in-hospital cardiac arrest: a single-center retrospective study

Abstract Background Epinephrine significantly enhances the rate of return of spontaneous circulation, and its early administration during cardiac arrest is recommended in both domestic and international resuscitation guidelines. However, the specific timing of epinephrine adminis...

Foliar polystyrene nanoplastics modulate cadmium uptake and root-to-shoot translocation in hydroponic Spinacia oleracea L.: Time- and concentration-dependent responses

The accumulation of plastics and heavy metals (HMs) in the environment has become a significant global concern due to their persistence, ubiquity, and potential ecological impacts. Atmospheric micro- and nanoplastics (MP, NP) are capable of undergoing long-range transport and can...

Effects of Sulfur Dioxide on Disease Resistance and Storage Quality of Durian (Durio zibethinus L.): A Comprehensive Analysis Integrating GC-IMS, HTS, Physiological and Biochemical Parameters

In this study, we examined the multifaceted effects of sulfur dioxide (SO2) on the postharvest preservation of durian and the underlying potential mechanism of disease resistance. Our results show that 2% SO2 preserved the good quality of durian by inhibiting its respiration rate...

Beyond Single‐Cause Explanations: An Integrated Framework for Crisis Learning in Public Organisations: A Survey Experiment in China

ABSTRACT Drawing on performance feedback, attribution, and accountability theory, this study investigates how the frequency of crises, the type of causal attribution, and the geographic location of an event jointly influence crisis learning among Chinese public sector actors. The...

Targeting delirium in gastric surgery: An interpretable predictive model and statistical analysis in critical care

Background Postoperative delirium is a serious complication in elderly ICU patients after gastric surgery, increasing mortality and healthcare burden. Early identification of high-risk patients may support timely prevention and optimise perioperative care. Objective To develop an...

Beyond Doomsday: reading Von Foerster’s 1960 equation as a lesson in second-order cybernetics

Purpose This article revisits the 1960 “Doomsday” equation of Von Foerster, Mora and Amiot on the anniversary of its author’s birth. It asks what the equation’s now-evident empirical deviation teaches about prediction in social systems, and argues that the deviation is best read...

Sequencing Deoxyuracil at Single-Base Resolution via a Hydrazine Reagent-Induced U-to-A Transition

Abstract Uracil is a canonical base in RNA, yet its presence in DNA represents the most common non-canonical modification, with broad implications for diverse physiological processes. However, due to the lack of suitable analytical methods, the distribution and biological functio...

Positively Charged Hollow Fiber Nanofiltration Membrane With an SPSf / PEI Bilayer Prepared via Dip‐Coating

ABSTRACT Nanofiltration (NF) has attracted considerable interest in water purification and resource recovery. Hollow fiber membranes offer high packing density, large surface‐area‐to‐volume ratio, and low‐pressure high‐flux operation. However, the fabrication of hollow fiber NF m...

In-race continuous glucose monitoring in highly trained male distance runners: a context-dependent reversal of the glucose–performance association between training and competition

Abstract To characterize in-race interstitial glucose dynamics in highly trained male distance runners using continuous glucose monitoring (CGM), and to test whether the direction of the glucose–performance association differs between actual competition and race-pace training. Fi...

Risk of Degenerative Spine Disease, Interventional Spine Procedures and Spine Surgery in Patients with Multiple Sclerosis

OBJECTIVES: To determine the association between Multiple Sclerosis (MS) and Degenerative Spine Disease (DSD) and the subsequent utilization of interventional pain (IVP) procedures and spine surgery. DESIGN: A retrospective, active comparator cohort study using TriNetX. Adults wi...

Omega-3 cord plasma proportions and cognitive function trajectories from 5 to 15 years of age: a population-based cohort study

Abstract Maternal diet during pregnancy, particularly omega-3 fatty acids, is critical for neurodevelopment, yet long-term associations with cognitive trajectories remain unclear. We evaluated prenatal omega-3 exposure in relation to longitudinal trajectories of inattentiveness,...

Diagnostic performance of CYFRA 21 − 1 and ProGRP in serum and bronchoalveolar lavage fluid for differentiating lung cancer from benign pulmonary diseases: a case–control study

Abstract Background Late presentation of lung cancer remains a major contributor to its poor prognosis. Identifying simple, minimally invasive biomarkers for differentiation between malignant and benign Pulmonary lesions is of significant clinical importance. Objective To evaluat...