Research works

Fertility Preservation for Reproductive-aged Women with Breast Cancer: A Contemporary Review

Abstract Purpose of Review Breast cancer is the most common malignancy in reproductive-age women, and its incidence is rising fastest in those under 50 as early-stage survival exceeds 90%. This review synthesizes current evidence on fertility preservation in breast cancer, focusi...

A Pre-Anchored Sling Technique for Vascular Transposition During Microvascular Decompression

Introduction: We describe a simple modification of sling-based vascular transposition during microvascular decompression (MVD). Methods: One end of the sling is anchored to the petrous dura or tentorium before vessel manipulation, and the free end is then wrapped around the offen...

Spatial distribution and spatiotemporal clustering of AIDS notifications among men in Brazil, 2014–2023: an ecological study

This study aimed to analyse the spatial distribution and spatiotemporal clustering of AIDS notifications among men in all 5570 Brazilian municipalities between 2014 and 2023. Using an ecological design, data on AIDS notifications among men (≥ 13 years) were retrieved from Brazil’...

Stable and efficient n-type scaffolded semiconductor for photocatalytic hydrogen production under tungsten light irradiation

Abstract The production of green hydrogen (H 2 ) is a sustainable strategy to address the current energy crisis without contributing to long-term greenhouse gas emissions. Many powder-based photocatalysts have shown great promise for light-driven H 2 generation; however, in eithe...

Chronotherapeutic considerations for antiplatelet therapy in cardiovascular risk prevention – A systematic review

Summary: Background: Cardiovascular physiology exhibits circadian rhythms, including a morning surge in platelet reactivity and cardiovascular events. Aligning the timing of antiplatelet therapy with these rhythms may be a simple, cost-effective approach to improve clinical effic...

Illness Meaning-Making in an Oncology Support Group: A Longitudinal Lexical Correspondence Analysis of Group Discourse

Living with cancer involves an ongoing effort to make sense of experiences that disrupt identity, relationships, and future expectations. Meaning-making is embedded in interpersonal and healthcare contexts, including psychosocial support settings where illness experiences are sha...

Mass Spectrometry Imaging for Mapping the Spatial Distribution of Bioactive Compounds in Medicinal Fungi: Applications, Challenges, and Future Perspectives

Mass spectrometry imaging (MSI), featuring label-free detection, minimal sample pretreatment, and simultaneous multi-constituent analysis, overcomes the loss of spatial information inherent in conventional homogenization–extraction methods, enabling in situ visualization of bioac...

Intraluminal thrombus burden is an independent imaging predictor of distal runoff impairment in popliteal artery aneurysms

Background : In popliteal artery aneurysms (PAAs), computed tomography angiography (CTA)-derived intraluminal thrombus burden and distal runoff vessel patency remain insufficiently characterized. We examined this relationship and the added value of thrombus burden assessment in C...

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Ovarian cancer is the most lethal gynecological malignancy, due to late‐stage diagnosis, tumor heterogeneity, and lack of biomarkers for early detection. Extracellular vesicles (EVs) in plasma and ascites offer a minimally invasive source of tumor‐derived information, yet their l...

Burst abdomen in a case of fatal high‐voltage electrocution: A rare entity

Abstract High‐voltage electrocution (>1000 volts) commonly presents with flash burns, flame burns, and injuries due to the entry and exit of current in the body. Sometimes, unusual injuries are encountered in high‐voltage electrocution. A burst abdomen with perforation of the gas...

Giant Plexiform Neurofibroma in Neurofibromatosis Type 1

This case report describes a pendulous hyperpigmented lesion with a ridged bag-of-worms surface, multiple café-au-lait macules, and axillary freckling across the patient’s trunk and arm.

Disease- and Region-Specific Molecular Patterns Involving miRNAs and Associated Signalling Pathways and Epithelial Cell-Fate Responses in PSC-Associated Ulcerative Colitis

Patients with primary sclerosing cholangitis-associated ulcerative colitis (PSC-UC) have an elevated risk of colorectal cancer compared with ulcerative colitis (UC), but the molecular mechanisms linking chronic inflammation to epithelial cell fate remain unclear. The present stud...

Analysis of immediate upstream gene regions in orthopoxvirus genomes through the use of DNA Duplex Stability and explainable machine learning

Orthopoxviruses are double-stranded DNA viruses with a temporally regulated gene expression program divided into early, intermediate, and late stages. Although many temporal gene functions are known, the promoter features that distinguish expression program require more precise c...

When heritage becomes a burden: an evidence-based reference class of tourism stress in historic cities

Overtourism and carrying-capacity models have traditionally explained heritage-city stress through visitor volume and density. However, these approaches provide limited explanation of why comparable tourism pressures produce different forms and levels of stress across historic ci...

Beyond similarity retrieval: governance fidelity, consistency, and minimality in long-term conversational memory

Abstract Conversational language model systems persist user constraints, preferences, identity, commitments, and assigned roles across turns. The dominant memory architecture stores this alongside ordinary episodic content in a vector index and retrieves the top- k items by simil...

Analysis of tensile properties, fracture characteristics, and microstructural features in friction stir welding of dissimilar aluminium alloys reinforced with Al 2 O 3

In the present investigation, dissimilar aluminium alloys AA2014-T6 and AA5083-H111 were joined using friction stir welding combined with in-situ reinforcement of aluminium oxide (Al2O3) particles. A single V-groove with an included angle of 45° was machined along the welded join...

Comparative Performance of Federated and Centralized Learning for Brain Tumor Classification and Segmentation

Purpose To compare federated learning (FL) and centralized learning (CL) performance for brain tumor classification and segmentation and examine whether specific configurations confer measurable performance advantages. Materials and Methods In this systematic review and meta-anal...

Terminal Compatibility and Admissibility of a Meridional Caputo Flow Rule in Transformed-Stress Clay Plasticity

A clay flow rule governs contraction or dilation during plastic shearing. We audit a terminal-directed scalar Caputo integral on a teardrop meridian under specified elasticity and hardening. Its zero coincides with the non-associated base-model terminal only if Ω = Ψ. Normally co...

Multi-Field Comparison of Homogeneous Cavitation Models in a Small Converging–Diverging Nozzle: A Controlled CFD Case Study

Homogeneous cavitation models are widely used in engineering CFD analyses of internal flows, but their predictions may differ depending on model formulation, operating regime, and geometry. This issue is especially relevant in small converging–diverging nozzles, where strong loca...

Exposure route, not dose, is the primary driver of infection patterns for a respiratory virus

Infectious disease severity, shedding, and within-host kinetics can vary substantially with exposure dose, inoculation route, and host factors. However, the relative contributions of these variables to infection heterogeneity remain poorly quantified because small sample sizes in...