Early measurement of ST2 and REG3α has a prognostic impact in haploidentical transplantation with post-transplant cyclophosphamide
Abstract
Research on predictive biomarkers in haploidentical SCT (haplo-HSCT) with post-transplant cyclophosphamide (PTCy) remains limited, particularly regarding the critical first week post-infusion. We prospectively evaluated serum ST2, REG3α, and the MAGIC algorithm pre-conditioning and at days 0, +7, +14, and +21 in 81 adult patients undergoing haplo-HSCT with PTCy. ST2 and REG3α surged significantly from pre-conditioning to day 0 (p=0.031 and p.
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Authors: Marta Fonseca Santos, María García‐Álvarez, Luis Antonio Corchete Sanchez, Luis A. Marín, Francisco Javier Gil‐Etayo, Rebeca Maldonado, Ana Isabel Sánchez, Inmaculada Sánchez-Villares, Ana García‐Bacelar, Rodrigo Gil-Manso, Alejandro Avendaño, Miriam López-Parra, Mónica Baile, Almudena Cabero, Maria Luisa Martín-Mateos, Olga López‐Villar, Sara Marcos, Ana África Martín, Estefanía Pérez, Mónica Cabrero, Fermin M. Sanchez-Guijo, Lourdes Vázquez, Ramón García‐Sánz, Miguel Alcoceba, Lucía López‐Corral
Institutions: Complejo Hospitalario Universitario de Albacete, Instituto de Investigación Biomédica de Salamanca, Centro de Investigación del Cáncer