HBr-Catalyzed Construction of Sulfur-Containing Heterocycles via Difunctionalization of Alkenes
Abstract
Abstract Sulfur-containing heterocycles are important chemical entities and key structural motifs in many biologically active molecules, representing valuable but synthetically challenging building blocks. Herein, we report a new method for the construction of sulfur-containing heterocycles under mild conditions using a green oxidative system composed of HBr and DMSO. This transformation employs inexpensive and readily available thiophenols as the sulfur source, operates without external photocatalysts and metals, and offers a general approach for the construction of small-ring and bridged-ring systems.
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Authors: Chao Xie, Zemin Wang, Shuhan Zhu, Ruihua Liu, Cong Shi, Hongyun Qin, Chao Liu, Ruyue Zhang, Yue Xu, Yuanyuan Zhao, Yingze Shu, Xiangqian Li, Dayong Shi
Institutions: Shandong University of Science and Technology, Shandong University of Technology, Shandong University, City University of Hong Kong, Shenzhen Research Institute