A CLINICOPATHOLOGICAL ANALYSIS OF THYROID CARCINOMAS

Abstract

Background: Thyroid cancers represent the most common malignancies of the endocrine system. Recent WHOclassification redefines thyroid neoplasms which is supposed to be in accordance with the prognosis. So, we analyzed thehistomorphological features and reclassified according to the WHO classification 2017 as not many studies have not beendone. Materials and Methods: This is a retrospective study of 75 cases of thyroid carcinomas diagnosed over a period of 3years which were reclassified as per WHO Classification of Endocrine Organs (2017). Statistical analysis: Data wereanalyzed in Excel using descriptive statistics (percentages). Results: Commonest thyroid carcinoma was PTC (Papillarythyroid carcinomas) (68%). 12 out of 37 previously diagnosed FVPC (Follicular Variant of Papillary thyroid Carcinoma)were reclassified; 10 cases (13.36%) as NIFTP (Non-invasive follicular thyroid neoplasm with papillary like nuclearfeatures) and 2 cases (2.66%) as WDT-UMP (Well differentiated tumor of uncertain malignant potential). Most commonPTC variant was FVPC (49.01%). Most frequently affected were females (male: female=1:4) aged between 31-40 years.Gradually increasing thyroid swelling (92%) was the commonest presentation. On histopathology, most of the NIFTPsshowed nuclear grooves (100%) and nuclear grade 3 (90%) while the WDT-UMPs showed diffuse unequivocal nuclearchanges of PTC but with questionable capsular invasion. Nuclear grooves, nuclear overlapping & ground glass nuclei werethe most common nuclear features in PTCs overall. Nuclear pseudoinclusions were more specifically seen in PTC.Conclusion: Thyroid carcinomas manifest a wide spectrum of histopathological features. Their proper recognition andcorrect diagnosis are essential for appropriate management.