P1.032. Frequency of Gastroesophageal Reflux Disease in Patients Depending on the Presence of Gastric Mucosal Atrophy

Abstract

Abstract Topic Benign Disease: Gastro-Esophageal Reflux and Hiatal Hernia Background Gastroesophageal reflux disease (GERD) affects 14% of adults worldwide. In patients with gastric mucosal atrophy, due to decreased acid production, the incidence of symptoms may be lower, necessitating further research into the epidemiological criteria of GERD. Methods As part of the epidemiological study, 4436 people were examined (men - 2138 (44.2%), women - 2590 (54.8%). The age of the subjects ranged from 18 to 84 years, the average age was 45.79 ± 15.12 years (median age was 44 (34; 58) years). All respondents underwent a blood test for "GastroPanel" (Pepsinogen I, Pepsinogen II). The results of GastroPanel were assessed by quantitative characteristics: atrophy of the gastric mucosa (Pepsinogen I ≤ 30 μg /l and the ratio Pepsinogen I / Pepsinogen II ≤ 3), no atrophy of the gastric mucosa (Pepsinogen I> 30 μg /l and Pepsinogen I/Pepsinogen II ratio>3). The criterion for GERD was the presence of heartburn and/or regurgitation once a week or more. Results Among 4436 subjects, a decrease in Pepsinogen I≤30 μg/l and a Pepsinogen I/Pepsinogen II ratio≤3 was detected in 292 individuals, which amounted to 6.2%. Normal levels of serum pepsinogens (SP) (Pepsinogen I>30 μg/L and a Pepsinogen I/Pepsinogen II ratio>3) were found in 4436 (93.8%) individuals. Among respondents with reduced SP levels (Pepsinogen I≤30 μg/l and Pepsinogen I/Pepsinogen II ratio≤3), the frequency of heartburn and/or regurgitation once a week or more was 9.6% (28 of 292), which was lower compared to the group with normal pepsinogen levels (Pepsinogen I>30 μg/l and Pepsinogen I/Pepsinogen II ratio>3) - 19.0% (844 of 4436). Conclusion In the group with reduced gastric acid production, a decrease in symptoms of gastroesophageal reflux disease was observed compared with the group with normal acid production.