Moscow Clinical Scientific Center

Effect of erector spinae plane block as a part of combined anesthesia on the incidence of postmastectomy pain syndrome

The incidence of postmastectomy pain syndrome (PMPS) after mastectomy ranges from 20% to 60%. Interfascial blockade of the erector spinae muscle (ESPB) can reduce pain in early postoperative period after total mastectomy and possibly reduce the incidence of PMPS. Objective. To ev...

Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients

Importance Female patients undergoing cardiac surgery have a higher transfusion burden, yet they remain underrepresented in randomized clinical trials. Although the ANH trial showed no significant reduction in the proportion of patients receiving allogeneic blood transfusions wit...

Atlas of cell types and regulatory elements underlying human facial diversity

Abstract Human genetic diversity generates an astonishing variety of facial shapes, and craniofacial anomalies rank among the most common birth defects. Identifying the cellular mechanisms that mediate the genome’s influence on facial variation remains a challenge. Here we create...

Efficacy of Potassium-Competitive Acid Blockers Versus Proton Pump Inhibitors in Eradication Regimens for Clarithromycin-Resistant Helicobacter pylori: A Systematic Review and Meta-Analysis

Background: Clarithromycin resistance represents the primary obstacle to the success of conventional proton pump inhibitor (PPI)-based triple therapy for Helicobacter pylori (H. pylori) eradication. Potassium-competitive acid blockers (P-CABs) offer faster and more potent acid su...

Local Glucocorticoid Metabolism in Post-traumatic Stress Disorder: The Emerging Role of 11-hydroxysteroid Dehydrogenases

Post-traumatic stress disorder (PTSD) is a complex psychiatric condition arising from exposure to severe trauma, characterized by intrusive memories, avoidance, negative alterations in cognition and mood, and hyperarousal.Despite advances in understanding its neurobiology, effect...

Expanding the Genomic Spectrum of NHLRC2-Associated FINCA Disease: Integrated Bioinformatic Characterization of a Novel Deep Intronic Variant Predicted to Activate a Pseudoexon

NHLRC2-associated FINCA disease is an ultra-rare autosomal recessive multisystem disorder caused by biallelic pathogenic variants in NHLRC2. Its mutational spectrum and genotype–phenotype correlations remain incompletely defined, and the contribution of non-coding variants is poo...

P1.010. Personalized Approach to Surgical Treatment of Epiphrenal Diverticula of the Esophagus

Abstract Topic Benign Disease: Esophageal Surgery Background Epiphrenal diverticula of the esophagus are a rare pathology, pathogenetically associated with disorders of esophageal motility. Despite the evolution of treatment methods towards minimally invasiveness, the incidence o...

P1.011. The Effect of Anxiolitics and Antidepressants in Distal Esphageal Patiets With Distal Esophageal Spazm

Abstract Topic Benign Disease: Esophageal Function and Motility Background Spastic esophageal diseases are rare, but they can worsen quality of life. Patients with esophagospasm often have a high level of anxiety. Treatment with antidepressants relieves symptoms, but does not imp...

P1.032. Frequency of Gastroesophageal Reflux Disease in Patients Depending on the Presence of Gastric Mucosal Atrophy

Abstract Topic Benign Disease: Gastro-Esophageal Reflux and Hiatal Hernia Background Gastroesophageal reflux disease (GERD) affects 14% of adults worldwide. In patients with gastric mucosal atrophy, due to decreased acid production, the incidence of symptoms may be lower, necessi...

SARIFA and Lipid Metabolic Reprogramming in Prostate Cancer: Fundamental Mechanisms, Tumor Microenvironment, and Novel Biomarker Prospects

Prostate cancer (PCa) is one of the most prevalent malignancies in men worldwide. Established clinicopathological parameters do not fully describe the biological heterogeneity of PCa or consistently predict its clinical course after radical prostatectomy, supporting the investiga...