Evaluation of the Impact of Summer Environmental Conditions on the Handling Convenience of Over-the-Counter Soft Capsules Based on Cases Where Liquid Contents Splashed During Removal from Press-Through Packaging
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Abstract
We investigated the impact of temperature and humidity on the convenience of handling over-the-counter (OTC) soft capsule drugs. Following a report of capsule rupture and liquid leakage in Product A, we performed controlled experiments using five products, including Product A. Capsules in the press-through packaging were stored under various conditions (20℃ or 35℃; high or low humidity) and evaluated for elongation rate under pressure, rupture rate, moisture absorption, and ease of removal from press-through packaging.
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View paper (DOI)Open access versionOpenAlexIryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)Published 2026-08-10
Authors: Yasushi Habu, Mahiro Shirakura, Haruki Nishijima, Takumi Hirayama, Miho Fujieda, Taisei Date, Susumu Takeshita, Aya Ino, Yukako Hatanaka
Institutions: Kobe Pharmaceutical University