Kobe Pharmaceutical University

Non-destructive colocalization sensing of microRNAs and membrane proteins in single vesicles reveals spatial inflammation signatures

Chronic inflammation underlies a broad spectrum of diseases, yet current liquid biopsy approaches lack the spatial resolution and molecular specificity to detect localized, disease-specific inflammatory signals. Extracellular vesicles (EVs) offer a promising alternative, as they...

Pd/Tl Bimetal-Catalyzed C8–H Alkenylation of Dimethoxycoumarins

Abstract A Pd/Tl bimetallic catalytic method for the regioselective C8–H alkenylation of dimethoxycoumarin scaffolds was developed. The synergistic effects of Tl(OCOCF3)3 and a Pd–thioether ligand catalytic system enabled electrophilic C–H bond activation, followed by Heck-type a...

Evaluation of the Impact of Summer Environmental Conditions on the Handling Convenience of Over-the-Counter Soft Capsules Based on Cases Where Liquid Contents Splashed During Removal from Press-Through Packaging

We investigated the impact of temperature and humidity on the convenience of handling over-the-counter (OTC) soft capsule drugs. Following a report of capsule rupture and liquid leakage in Product A, we performed controlled experiments using five products, including Product A. Ca...