Penile Metastasis From Castration‐Resistant Prostate Cancer: A Case Report

Abstract

ABSTRACT Introduction Penile metastasis from prostate cancer—generally associated with a poor prognosis—is rare and underreported. We report one relevant case. Case Presentation The patient was a 65‐year‐old male with metastatic hormone‐sensitive prostate cancer (prostate‐specific antigen [PSA]: 500 ng/mL) and lung, bone, and lymph node metastases. The patient received luteinizing hormone‐releasing hormone agonist monotherapy. The patient developed castration‐resistant prostate cancer and received androgen receptor signal inhibitor therapy and chemotherapy. As the disease progressed, a mass formed on his penis; biopsy revealed prostate cancer penile metastasis. The patient died 5 months later. Conclusion Penile metastasis is rare and typically observed in advanced prostate cancer stages. Awareness may aid in early recognition, guide palliative management, and support patient counseling.