SHOWA Medical University

Response to “Trial design, conflict of interest, and evidence independence in the JASMINE trial and its economic evaluations”

The JASMINE study was designed as a multicenter, randomized Phase III registration trial (jRCT2031210384) conducted under the Japanese Good Clinical Practice (GCP) framework to evaluate the safety and efficacy of an exclusive human milk diet (EHMD) in Japanese very low birth weig...

A Pre-Anchored Sling Technique for Vascular Transposition During Microvascular Decompression

Introduction: We describe a simple modification of sling-based vascular transposition during microvascular decompression (MVD). Methods: One end of the sling is anchored to the petrous dura or tentorium before vessel manipulation, and the free end is then wrapped around the offen...

Role of calcineurin B homologous protein 3 in C2C12 myogenic differentiation

Calcineurin B homologous protein 3 (CHP3), also known as tescalcin, has been implicated in the regulation of cardiomyocyte hypertrophy, but its function in skeletal muscle remains unclear. Here, we investigated the role of CHP3 in C2C12 myogenic differentiation. CHP3 expression w...

How I do it: a target-tailored lateral basal approach for selected cerebellopontine angle and adjacent skull base lesions

Abstract Background The lateral basal approach (LBA) is an anatomy-guided posterolateral skull base route; its contribution is not supine positioning or fixed-retractor avoidance alone. Method Layer-by-layer dissection of the interlaminar fatty tissue and jugular process removal...

Reproducibility of the Cepstral Spectral Index of Dysphonia in Tracheoesophageal Speech and Exploratory Associations with Clinical Communication Measures

Background/Objectives: The Cepstral Spectral Index of Dysphonia (CSID) was developed for laryngeal dysphonia. We evaluated task-specific reproducibility in tracheoesophageal (TE) speech and associations with communication measures and surgical/anatomical configuration. Methods: F...

Perceptions and information needs regarding household exposure to anticancer drugs among family members living with patients receiving outpatient chemotherapy in Japan: A qualitative descriptive study

Introduction As outpatient chemotherapy has become increasingly common, family members may be exposed to anticancer drugs in daily life through contact with patients' body fluids and contaminated environments. However, little is known in Japan about family members' perceptions of...

Orthodontic and surgical treatment patterns in hemifacial microsomia: a retrospective multi-institutional study in Japan

Hemifacial microsomia is a congenital craniofacial condition characterized by variable facial asymmetry and mandibular hypoplasia. Its management often requires long-term multidisciplinary care, including orthodontic and surgical treatment. However, multi-institutional data on tr...

YAP1 induces hepatocellular carcinoma via DNA demethylation rather than by canonical driver gene mutations

Abstract Large-scale genome sequencing analyses have identified driver gene mutations (DGMs) in most cancers as well as their associated tumorigenic mechanisms. However, a small fraction of cancers are not positive for these canonical DGMs, leaving the mechanisms underpinning the...

Exopolysaccharides From Lactobacillus delbrueckii subsp. bulgaricus OLL1073R‐1 Enhance Macrophage Bactericidal Activity Through IL‐12‐Dependent Macrophage–NK Cell Crosstalk

ABSTRACT Exopolysaccharides (EPS) produced by Lactobacillus delbrueckii subsp. bulgaricus OLL1073R‐1 have been reported to exert immunomodulatory effects, primarily in antiviral responses; however, their role in antibacterial host defense remains unclear. Here, we investigated wh...

Seated Versus Standing Endoscopic Retrograde Cholangiopancreatography: Association With Operator Fatigue and Pain

Background and study aims Endoscopic retrograde cholangiopancreatography (ERCP) is a physically demanding procedure for operators that can provoke musculoskeletal symptoms. However, burden reduction and operating performance from a seated operating posture have not been establish...

Thermal regulation of monocrystalline and polycrystalline photovoltaic panels using phase change material for high temperature applications

Thermal regulation of photovoltaic (PV) panels is essential, as electrical efficiency decreases with increasing operating temperature. However, the electrical efficiency of these panels still no reach to maximum level, and authors have investigated various fluids and materials fo...

Long-term prescribing patterns of hormone therapy and concomitant medications among women with menopausal disorders: a 20-year retrospective database study in Japan

Abstract Background Hormone therapy is an effective treatment for menopausal symptoms, but its use has changed substantially since the Women’s Health Initiative report. Long-term real-world data on hormone therapy and concomitant medication prescribing in Japan remain limited. Me...

Institutional enrollment volume and clinical outcomes after surgery or chemoradiotherapy for clinical stage I esophageal squamous cell carcinoma: a supplementary analysis of JCOG0502

Abstract Background Surgery and chemoradiotherapy (CRT) are standard options for clinical stage I esophageal squamous cell carcinoma (ESCC). JCOG0502, a multicenter, non-randomized, parallel-group comparison, demonstrated the non-inferiority of definitive CRT compared with surger...

Long-Term Survival Outcomes of Modified-FOLFOXIRI Plus Cetuximab Versus Bevacizumab in RAS / BRAF Wild-Type Metastatic Colorectal Cancer: Final Analysis of the DEEPER Trial

The randomized phase II DEEPER trial (jRCTs061180022) previously reported superior depth of response with modified 5-fluorouracil, leucovorin, oxaliplatin and irinotecan (m-FOLFOXIRI) plus cetuximab versus bevacizumab in patients with RAS wild-type metastatic colorectal cancer (m...

Ionizing Radiation and Ultraviolet Light Irradiation‐Associated DNA Damage Increasing Genomic Instability Risk

ABSTRACT Cancer frequently develops in association with genomic instability, which includes massive induction of chromosomal structural variants (SVs) and single nucleotide variants (SNVs). SVs are typically caused by erroneous repair of DNA double‐strand breaks (DSBs) and are ti...

Effectiveness of Clazosentan Combined with Ozagrel for Aneurysmal Subarachnoid Hemorrhage: A Retrospective Comparative Study

Abstract Clazosentan, a selective endothelin A receptor antagonist, has recently emerged as an essential therapy for aneurysmal subarachnoid hemorrhage (aSAH) in Japan. However, evidence regarding combination therapy with adjunctive agents remains unclear. We retrospectively comp...

Role of Astrocytes in Central Respiratory Control

Astrocytes, once regarded primarily as structural and metabolic support cells, are now increasingly recognized as active participants in neural information processing. Within respiratory control networks, astrocytes are widely distributed throughout the brainstem and spinal cord,...

Penile Metastasis From Castration‐Resistant Prostate Cancer: A Case Report

ABSTRACT Introduction Penile metastasis from prostate cancer—generally associated with a poor prognosis—is rare and underreported. We report one relevant case. Case Presentation The patient was a 65‐year‐old male with metastatic hormone‐sensitive prostate cancer (prostate‐specifi...

Longitudinal Stent Malapposition After Microcatheter Removal Is Associated With Incomplete Occlusion After Pipeline Flow Diversion

BACKGROUND AND OBJECTIVES: Flow diversion is an established treatment strategy for intracranial aneurysms; however, incomplete aneurysm occlusion remains a clinically relevant challenge. Adequate stent-vessel wall apposition is considered critical for aneurysm healing, yet the im...

Three-DimensionalDescriptions of π/π,CH/π, and Halogen/π Interactions Formed between PhenylSubstructures

Abstract π/π, CH/π, and halogen/π interactions are key intermolecular interactions in molecular design for drug discovery and materials science. Three-dimensional (3D) characterization of these interactions is essential for rational molecular design, as molecules typically form n...