SHOWA Medical University

Ionizing Radiation and Ultraviolet Light Irradiation‐Associated DNA Damage Increasing Genomic Instability Risk

ABSTRACT Cancer frequently develops in association with genomic instability, which includes massive induction of chromosomal structural variants (SVs) and single nucleotide variants (SNVs). SVs are typically caused by erroneous repair of DNA double‐strand breaks (DSBs) and are ti...

Effectiveness of Clazosentan Combined with Ozagrel for Aneurysmal Subarachnoid Hemorrhage: A Retrospective Comparative Study

Abstract Clazosentan, a selective endothelin A receptor antagonist, has recently emerged as an essential therapy for aneurysmal subarachnoid hemorrhage (aSAH) in Japan. However, evidence regarding combination therapy with adjunctive agents remains unclear. We retrospectively comp...

Role of Astrocytes in Central Respiratory Control

Astrocytes, once regarded primarily as structural and metabolic support cells, are now increasingly recognized as active participants in neural information processing. Within respiratory control networks, astrocytes are widely distributed throughout the brainstem and spinal cord,...

Penile Metastasis From Castration‐Resistant Prostate Cancer: A Case Report

ABSTRACT Introduction Penile metastasis from prostate cancer—generally associated with a poor prognosis—is rare and underreported. We report one relevant case. Case Presentation The patient was a 65‐year‐old male with metastatic hormone‐sensitive prostate cancer (prostate‐specifi...

Longitudinal Stent Malapposition After Microcatheter Removal Is Associated With Incomplete Occlusion After Pipeline Flow Diversion

BACKGROUND AND OBJECTIVES: Flow diversion is an established treatment strategy for intracranial aneurysms; however, incomplete aneurysm occlusion remains a clinically relevant challenge. Adequate stent-vessel wall apposition is considered critical for aneurysm healing, yet the im...

Three-DimensionalDescriptions of π/π,CH/π, and Halogen/π Interactions Formed between PhenylSubstructures

Abstract π/π, CH/π, and halogen/π interactions are key intermolecular interactions in molecular design for drug discovery and materials science. Three-dimensional (3D) characterization of these interactions is essential for rational molecular design, as molecules typically form n...

Safety and reduction of pasteurized donor human milk waste using a 48-h post-thaw usage policy: a retrospective observational and bacteriological study

Abstract Background Pasteurized donor human milk (PHDM) is recommended for preterm infants when the mother’s own milk is unavailable, as it reduces complications such as necrotizing enterocolitis and supports the early initiation of human milk feeding. Current guidelines in Japan...

Serial ultrafine endoscopic assessment of fibrin deposition and neomembrane formation in peritoneal dialysis patients using low glucose degradation product fluid

Preservation of the peritoneum is essential for the safe continuation of peritoneal dialysis (PD). Although PD fluid with low glucose degradation products (low GDP) are widely used, objective macroscopic assessment of the peritoneum during ongoing PD remains limited. We therefore...