Health & Medicinearticle2026-08-05

Papillary Fibroelastoma Causing Large-Vessel Ischemic Stroke in a Young Patient: Histopathologically Confirmed Tumor Embolism Treated With Mechanical Thrombectomy

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Abstract

Papillary fibroelastoma (PFE) is a benign cardiac tumor that, despite having significant embolic potential, is typically an uncommon cause of large-vessel ischemic stroke. We report a 19-year-old female who presented with acute aphasia and right hemiplegia due to a left middle cerebral artery M1 occlusion and was successfully treated with mechanical thrombectomy. Histopathologic examination of the retrieved embolus established the diagnosis. This case underscores the diagnostic importance of pathological examination of thrombectomy specimens when identifying rare cardioembolic etiologies of cryptogenic stroke.

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View paper (DOI)Open access versionOpenAlexJournal of Neurology ResearchPublished 2026-08-05

Authors: Ian Kim, Thomas R. Marotta, David G. Munoz

Institutions: University of Toronto