Biochemistry, Genetics and Molecular Biology · Molecular Biology

RNA Research and Splicing

RNA splicing tools can follow irrelevant clues and miss RNA’s shape

Deep-learning tools for predicting RNA splicing can rely on genomic clues unrelated to splicing and miss important effects of RNA structure, a study finds. These weaknesses were linked to systematic errors, especially when the tools evaluated sequences that differed from those used for training.

20 hours ago·5 views

Abstract editorial illustration accompanying the article: New ribosome method finds thousands of tiny protein-coding regions in mouse embryos

Biology

New ribosome method finds thousands of tiny protein-coding regions in mouse embryos

A Nature Communications study describes Ribo-ITP, a ribosome-based method designed to find previously hard-to-detect protein-coding regions (translons) using far less starting material. Using samples such as microdissected mouse brain tissue and single early embryos, the researchers report discovering thousands of translons and test whether they can drive protein production.

3 weeks ago·18 views