Zunyi Medical University

CircLAMC1 attenuates NSCLC malignant progression through modulation of the miR-27a-3p/PAQR3/NF-κB/p53 axis

Non-small cell lung cancer, the predominant subtype of lung cancer, is associated with high mortality and poor prognosis, underscoring the need for novel therapeutic targets. CircRNAs have emerged as important regulators of tumor progression owing to their high stability and tiss...

Lung ultrasound-guided protocolized fluid management versus conventional central venous pressure-based management in monitoring extravascular lung water during the perioperative period of percutaneous nephrolithotomy: a randomized controlled trial

Background Percutaneous nephrolithotomy (PCNL) is a common surgical intervention to treat renal calculi. Excessive irrigation fluid absorption during surgery may enhance extravascular lung water (EVLW) level. Hence, accurate monitoring and protocolized management of EVLW are cruc...

Pediatric 7 Tesla MRI: Current Applications and Future Opportunities

Utilization of ultra-high-field (UHF) MRI in humans has rapidly increased over the past decade, following regulatory approval of the first clinical 7 Tesla (7T) platforms in 2017 for brain and knee imaging. Currently, there are approximately 140 MRI scanners worldwide operating a...

Preclinical Evaluation of 89Zr-Labeled Anti-Nectin-4 Antibody for Enhanced PET Imaging in Bladder Urothelial Carcinoma

Abstract This study evaluated the preclinical performance of a novel 89Zr-labeled anti-Nectin-4 monoclonal antibody, [89Zr]Zr-DFO-MW282, for PET imaging of bladder urothelial carcinoma (BUC). [89Zr]Zr-DFO-MW282 was prepared via p-isothiocyanatobenzyl-desferrioxamine (p-NCS-Bn-DFO...

Identification and analysis of obesity-cellular senescence associated key genes in metabolic syndrome based on transcriptomic data

The Intricate relationship between obesity, cellular senescence, and metabolic syndrome (MetS) remains elusive. This study aimed to elucidate mechanisms involving obesity-related genes (ORGs) and cellular senescence-related genes (CSRGs) in MetS. Transcriptomic profiles from the...

Improved Functionality and Emulsifying Stability of Chickpea Protein Microgel–Mung Bean Hull Fiber Conjugates via Combined Physicochemical Pretreatment

Native chickpea protein isolate (CPI) exhibits unsatisfactory solubility and dispersibility, restricting its interfacial performance and emulsion-stabilizing capacity. Herein, CPI gels were subjected to combined high-pressure homogenization and ultrasonication pretreatment to fab...

Integrated Multi-Omics Profiling of Thymoma Identifies Subtype-Specific Remodeling and Myasthenia Gravis-Associated Targets

Abstract Thymoma is a rare thymic epithelial tumor strongly associated with myasthenia gravis (MG), yet the tumor intrinsic molecular states underlying this link remain unclear. Here, we profiled paired thymoma and distant nontumorous thymic tissues using untargeted metabolomics,...

Chemodivergent Synthesis of Indole Derivatives: [2 + 3]-Annulation of Oxindole-Derived MBH Carbonates with α-Enolic Dithioesters and Subsequent Branching Transformations

Abstract A chemodivergent synthetic strategy for constructing a series of structurally diverse indole derivatives has been developed, utilizing oxindole-derived Morita-Baylis-Hillman (MBH) carbonates and α-enolic dithioesters as key building blocks. By leveraging the unique react...

Integrated murine and human transcriptomics prioritizes a multicellular mitochondrial signature associated with immune and parenchymal features in NAFLD/MASLD

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), historically termed nonalcoholic fatty liver disease (NAFLD), involves metabolic dysregulation, mitochondrial stress, and immune remodeling. However, disease-associated multicellular transcriptional progra...

B-Cell Immune Responses in Myocarditis: Mechanisms, B-Cell Receptor Repertoire, and Clinical Translation

Myocarditis is an inflammatory myocardial disease induced by infection, autoimmunity, or immune checkpoint inhibitor (ICI) therapy. Its immunopathogenesis has long been attributed primarily to T-cell-mediated cellular immunity. Increasing evidence now indicates that B cells contr...

Development and validation of a machine learning model for predicting refracture risk in older adults with osteoporotic vertebral compression fractures

Osteoporotic vertebral compression fractures (OVCFs) are common among older adults and are associated with a high risk of subsequent vertebral refracture, which may result in functional decline and reduced quality of life. However, effective tools for identifying Older Adults at...

Isoptericola maris sp. nov., a novel actinobacterium isolated from the marine sediment in the Bohai Sea, China

A Gram-staining positive, greenish-yellow, immotile, catalase-positive, oxidase-negative actinobacterium, designated strain G70 T , was isolated from the marine sediment in the Bohai Sea, China. The results of phylogenetic analysis based on the 16S rRNA gene sequences indicated t...

CSNK2B-associated epilepsy: family report and literature review

Abstract Background CSNK2B mutations are associated with Poirier-Bienvenu neurodevelopmental syndrome (POBINDS), in which epilepsy is a common clinical feature. To describe the epilepsy phenotype of CSNK2B mutations, we reported a family with a novel CSNK2B mutation, added this i...

Bardoxolone methyl exerts an inhibitory effect on respiratory syncytial virus infection by downregulating IL-6 via the IKKβ/NF-κB signaling pathway

ABSTRACT Respiratory syncytial virus (RSV) causes severe lower respiratory tract infections in infants, older adults, and immunocompromised individuals, but therapeutic options for active infection remain limited. Interleukin-6 (IL-6) contributes to RSV replication and RSV-induce...

Effects of self-acupressure on the fatigue-sleep disturbance-depression symptom cluster in breast cancer survivors: a phase III randomised controlled trial

PURPOSE: To explore the effectiveness and safety of self-acupressure intervention on the fatigue-sleep disturbance-depression symptom cluster (FSDSC) among breast cancer (BC) survivors and to explore within-trial costs associated with the intervention. METHODS: Eligible participa...

LiCoO 2 /LiMn 0.6 Fe 0.4 PO 4 Composite Cathode with Enhanced Interfacial Structure Enables Long‐Life Lithium‐Ion Batteries

ABSTRACT Extending the cycle life of LiCoO 2 (LCO) cathodes under elevated cutoff voltages remains a critical challenge for lithium‐ion batteries, as accelerated degradation is often governed by reaction heterogeneity and interfacial instability. Herein, we report a composite cat...

Lactate suppresses innate immunity in Caenorhabditis elegans by excessive activation of SKN-1 associated with histone H4K16 lactylation

Histone lactylation is a recently identified epigenetic modification that directly couples cellular metabolic state with gene expression. Whether lactate affects host resistance to pathogens via histone lactylation remains unclear. Here, we found that infection with Pseudomonas a...

Ubiquitination in influenza a virus-host interactions

As a key pathogen responsible for zoonotic respiratory tract infections, Influenza A virus (IAV) is capable of undergoing antigenic drift and antigenic shift. These two mechanisms result in annual global epidemics caused by IAV, with occasional pandemics. Ubiquitination is an imp...

Molecular engineering of peptide-drug conjugates: strategies for enhancing precision oncology

Malignant neoplasms remain a formidable challenge to global public health, representing the second leading cause of mortality worldwide. While conventional small-molecule chemotherapeutics have historically served as a cornerstone of clinical oncology, their clinical utility is s...

Integrated multi-omics analysis identifies AKR1B15 and SLC4A10 as prognostic candidate citrullination-related genes associated with metabolic and immune programs in hepatocellular carcinoma

Protein citrullination has been increasingly implicated in tumor progression and immune regulation, but the prognostic and cellular characteristics of citrullination-related genes (CRGs) in hepatocellular carcinoma (HCC) remain incompletely understood. We integrated bulk transcri...