Zunyi Medical University

Altered TAGLN Expression During HBV Replication Correlates with OPA1 Levels

Hepatitis B virus (HBV) exploits host proteins to reshape cellular physiology and metabolism, thereby supporting its replication. Transgelin (TAGLN), an actin-binding protein highly expressed in HBV-associated hepatocellular carcinoma, has a poorly defined role in HBV infection....

First-line immune checkpoint inhibitors versus chemotherapy in delaying quality of life deterioration in advanced NSCLC: a systematic review and meta-analysis

Backgroud: Immune checkpoint inhibitors (ICIs) have transformed first-line treatment for advanced non–small-cell lung cancer (aNSCLC). While overall survival(OS) remains the primary endpoint, health-related quality of life (HRQoL) is a key patient-centered outcome. Time to deteri...

Application of a virtual simulation platform combined with the presentation-assimilation-discussion class in human morphology practical teaching: a quasi-experimental study

Abstract Background Human Morphology integrates anatomy, histology, and embryology and requires students to connect macroscopic and microscopic structures. Traditional practical teaching may be constrained by limited specimen availability, restricted classroom time, and passive l...

Characterization of Antioxidant Constituents and Geographical Differentiation of Polygonum multiflorum Thunb. Leaves Using 2D-LC-ECD and UHPLC-Orbitrap-MS/MS

This study established an activity-oriented analysis method based on offline two-dimensional liquid chromatography–electrochemical detection (2D-LC-ECD) combined with ultra-high-performance liquid chromatography–Orbitrap-MS/MS (UHPLC-Orbitrap-MS/MS), which was used to comprehensi...

TargetingArginine Metabolism via ArcR: BlestriareneB Suppresses Staphylococcus aureus BiofilmFormation and Cellular ATP Production

Abstract Blestriarene B (BB), a biphenanthrene compound isolated from the medicinal plant Bletilla striata, possesses antibacterial properties against Staphylococcus aureus; however, its molecular target and underlying mechanisms remain unclear. Arginine metabolism plays a pivota...

A deep learning model utilizing H&E-stained images for predicting HER2-low expression in breast cancer

The development and clinical application of novel HER2-targeted antibody-drug conjugates (ADCs) have significantly improved outcomes for breast cancer patients with HER2-low expression. The efficacy of such therapies critically depends on accurate assessment of HER2-low status. H...

The role of C-reactive protein to lymphocyte ratio and sleep duration in heart failure: exploring the mechanistic interplay and clinical implications

Heart failure (HF) is a progressive disease with complex pathogenesis involving inflammation, immune dysfunction, and metabolic abnormalities. Although C-reactive protein (CRP) is an established HF marker, the CRP-to-lymphocyte ratio (CLR) integrates inflammatory and immune respo...

Sitravatinib combined with osimertinib overcomes acquired osimertinib resistance in NSCLC by targeting AXL and the PI3K/AKT/GSK3β signaling pathway

The emergence of acquired resistance to osimertinib has emerged as a severe plight in the clinical management of patients with advanced harboring epidermal growth factor receptor mutations non-small cell lung (NSCLC). We comprehensively evaluated sitravatinib, an emerging multita...

Coupling Effects of Texture Density and Counterpart Material Hardness on the Dry Sliding Friction of TC4 Titanium Alloy

Circular microtextures with area densities of 5%, 10%, 15%, and 20% were fabricated on TC4 titanium alloy surfaces and tested under dry sliding conditions against four counterpart balls of varying hardness (Brass, SUS304, AISI 52100, and K20). Through coefficient of friction (COF...

Inspiring green action at work: CSR, admiration, and environmental self-efficacy as drivers of energy-sustainable behavior in China's hospitality industry

This study examines how corporate social responsibility (CSR) promotes employees' energy-related pro-environmental behavior in China's hospitality industry. Drawing on the theory of planned behavior as an organizing framework, the model treats CSR as an organizational cue that sh...

Multi-algorithm consensus clustering identifies four subphenotypes in sepsis-associated acute kidney injury

Sepsis-associated acute kidney injury (SA-AKI) is a highly heterogeneous syndrome with variable clinical trajectories and outcomes. Conventional staging systems, such as KDIGO, fail to capture this heterogeneity, limiting risk stratification and personalized management. We aimed...

A novel prognostic model based on CD8+T cell infiltration-associated differentially expressed genes and immune-related genes predicts survival in bladder cancer

To develop a robust prognostic model for bladder cancer (BLCA) by integrating genes associated with CD8 + T cell infiltration disparities and immune-related pathways. Transcriptomic and clinical data for BLCA were acquired from The Cancer Genome Atlas (TCGA) and the Gene Expressi...

FGF12, a FoxO1-downregulated gene, promotes the survival of trophoblast cells in gestational diabetes mellitus: a preliminary study

OBJECTIVES: Gestational diabetes mellitus (GDM) is a common pregnancy complication associated with adverse maternal and fetal outcomes. Although the prevalence of GDM is high, the molecular mechanisms involved in GDM-related placental dysfunction remain poorly understood. This st...