Zhuhai People's Hospital

The Effect of the MTHFR C677T Genotype Polymorphism on the Efficacy of Folic Acid Treatment for Hyperhomocysteinemia and Cardiovascular Endothelial Function

ABSTRACT Background Cardiovascular disease remains a major public health burden. This study aimed to investigate the effect of the methylenetetrahydrofolate reductase (MTHFR) C677T genotype on folic acid treatment response and cardiovascular endothelial function in patients with...

Content characteristics and informational reliability of postoperative pain–related videos on TikTok and Bilibili: a cross-sectional study

Postoperative pain is common and clinically important. Poor pain control may delay recovery, increase readmission risk, contribute to chronic postsurgical pain, and impair long-term quality of life. Meanwhile, patients and caregivers increasingly seek pain-related information on...

Functional Zone LST Patterns, Green-Space–LST Associations, and 2D/3D Urban-Form Relationships Across Taiyuan, Chengdu, and Yinchuan

Using selected summer Landsat 8 scenes for Taiyuan, Chengdu, and Yinchuan, this study compared functional zone land surface temperature (LST) patterns, green-space–LST associations, and the relationships of 2D landscape configuration, blue-green composition, 3D building form, and...

Prognostic factors and nomograms predicting overall survival and cancer specific survival for patients with rare histological variant prostate cancer

Our study aimed to develop nomograms to accurately predict the 1-, 3-, and 5-year overall survival (OS) and cancer-specific survival (CSS) of patients with rare histological variant prostate cancer (PCa) based on clinicopathological characteristics. We gathered clinicopathologica...

A waveguide kinetics framework for electrochemical polarization

The hydrogen evolution reaction (HER) and the hydrogen oxidation reaction (HOR) constitute the core electrochemical processes in a wide array of clean energy technologies, including but not limited to, water-splitting systems and fuel cells. However, the HER and HOR exhibits an a...

Analysis of the pathogenic spectrum and epidemiological characteristics of 22 respiratory pathogens in Zhuhai City, China, 2024–2025

Abstract Objectives Effective surveillance of respiratory infectious diseases is crucial for precise prevention and evidence-based public health response. This study analyzed the etiological spectrum of respiratory pathogens in Zhuhai, a high-mobility port city, from January 2024...

Causal Effects of Lipoproteins and Lipids on Atrial Fibrillation: A Mendelian Randomization Study

ABSTRACT Background and AimsThe relationship between blood lipids and atrial fibrillation (AF) remains unclear. Nuclear magnetic resonance (NMR) spectroscopy enables the profiling of size‐defined lipoproteins and their contained lipid components. This study aimed to analyze the g...

Pharmacological interventions targeting cognition and related clinical outcomes in vascular dementia: a systematic review and meta-analysis of randomized controlled trials

Abstract Purpose Randomized evidence for pharmacological interventions in vascular dementia (VaD) is fragmented. We conducted a VaD-focused, scale-specific systematic review and meta-analysis. Methods We searched four databases for English-language parallel-group randomized contr...

The efficacy of stem cell therapy: cells or their microenvironment?

The therapeutic outcomes of stem cell therapy are determined not solely by cellular potency alone, but also by the receptiveness of the host microenvironment. Despite continuous progress in stem cell quality control and functional optimization technologies, inconsistent outcomes...

Genomic insights into replicons and conjugative transfer systems of blaNDM-positive plasmids in the Enterobacter cloacae complex

The Enterobacter cloacae complex (ECC) represents a prominent opportunistic pathogen associated with multidrug-resistant nosocomial infections. The emergence of New Delhi metallo-β-lactamase (NDM)-producing ECC isolates presents a significant threat to public health, owing to the...

Senkyunolide I Inhibits mtDNA‐cGAS‐STING Signaling in Macrophages via Targeting VDAC1 Oligomerization to Attenuate Ulcerative Colitis

Ulcerative colitis (UC) is a chronic inflammatory bowel disease with limited therapeutic options. The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway, activated by cytosolic mitochondrial DNA (mtDNA), has been increasingly implicated in UC. Through p...