Zhongshan Hospital of Xiamen University

METTL14-dependent N6-methyladenosine modification of FGF16 participates in IGFBP5 deficiency-enhanced angiogenesis

Abstract N 6 -methyladenosine (m 6 A) RNA modification plays critical roles in physiological and pathological processes. Our prior study demonstrated that IGFBP5 expression is upregulated in the ischemic limb, whereas endothelial-specific IGFBP5 knockout (Igfbp5 EKO ) protects ag...

METTL14-dependent N6-methyladenosine modification of FGF16 participates in IGFBP5 deficiency-enhanced angiogenesis.

A-FGF16 axis may offer novel therapeutic strategies for ischemic disease.

Artificial intelligence empowers full-stack histopathological diagnosis and prognosis of renal cell tumor: a multi-center study with external validation

BACKGROUND: The rapid advancement of digital pathology has opened unprecedented opportunities for intelligent diagnosis in renal cell tumor. However, there remains a significant gap in the availability of reliable deep learning models capable of comprehensive kidney cancer detect...

Diagnostic accuracy, time window estimation, and prognostic value of diffusion-weighted MRI in acute ischemic stroke: a systematic review and meta-analysis

Diffusion-weighted imaging (DWI) is central to acute ischemic stroke (AIS) management; however, its performance varies across different clinical applications. This systematic review and meta-analysis comprehensively evaluated the diagnostic accuracy, time window estimation capabi...

Gliomas grading prediction using multicenter 3T Magnetic Resonance Spectroscopy

Abstract Background Magnetic Resonance Spectroscopy (MRS) is a non-invasive imaging technique that detects various metabolites in brain tissues, making it essential for the grading of brain gliomas. MRS measures key metabolites such as N-acetyl-aspartate (NAA), choline (Cho), and...