Zhongshan Hospital of Xiamen University

Few-shot learning for expert consensus severity stratification in newly diagnosed crohn’s disease

Early and accurate assessment of disease severity is important for standardizing baseline risk stratification and supporting treatment planning in newly diagnosed Crohn’s disease. This study used electronic medical record data, a few-shot learning algorithm, and SHAP-based interp...

Valproic Acid Inhibits Glioma Cell Proliferation by Inducing Neuronal‐Like Differentiation Partly Through HDAC1/REST Suppression

ABSTRACT Inducing differentiation of glioma cells, including glioma stem cells (GSCs), into neuron‐like cells represents a promising therapeutic strategy. Our previous drug repositioning study revealed that histone deacetylase (HDAC) inhibitors are potential inducers of glioma ce...

USP53 regulates glycolytic reprogramming and accelerates Abdominal aortic aneurysm progression and rupture

Abdominal aortic aneurysm (AAA) rupture remains a fatal vascular event with limited mechanistic understanding beyond diameter-based risk assessment. Emerging evidence suggests that metabolic reprogramming contributes to aneurysm progression, yet regulators linking metabolism to r...

Three-decade trends in nonalcoholic fatty liver disease across 204 countries and territories

Nonalcoholic fatty liver disease (NAFLD) has emerged as a leading chronic liver disease globally, driven by the rising incidence of obesity, type 2 diabetes, and metabolic syndrome. Despite the increasing burden, most studies focus on prevalence rather than incidence, leaving a g...

Supramolecular Chiral Assemblies from Benzoselenadiazole‐Alanine‐Acylhydrazone Conjugates Enable Cardioprotection

ABSTRACT Integrating structural order, permanent porosity, aqueous stability, and biological activity within a single supramolecular platform remains a central challenge in biomaterials science. Herein, we report a C 3 ‐symmetric conjugate ( TASe ) that unites benzoselenadiazole,...

Combined femoral nerve block and posterior knee pain-point infiltration for early passive knee training after total knee arthroplasty: a two-center sham-controlled proof-of-concept randomized trial

Abstract Background We assessed whether a combined regional analgesic regimen administered immediately before passive knee training on postoperative day 3 was associated with active knee range of motion (ROM) 90 days after the intervention. Methods In this two-center, parallel-gr...

Low education and incident complete tooth loss: cross-national associations and cohort-specific mediation pathways in HRS and CLHLS

Low educational attainment reflects accumulated socioeconomic disadvantage and may contribute to severe oral health inequalities across the life course. Whether its association with incident complete tooth loss is consistent across populations with different social and behavioral...

Periodic Mesoporous Metal Oxides With Consistent Structure and Complementary Sensing Selectivity for Reliable Artificial Olfactory

The integration of functional materials and intelligent algorithms has endowed artificial olfactory systems with promising potential across various fields. Nevertheless, their accuracy and reliability in practical gas recognition remain constrained, primarily due to the unrefined...

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

ABSTRACT The immunosuppressive microenvironment limits immunotherapy in triple‐negative breast cancer (TNBC). Interleukin‐15 (IL‐15) activates cytotoxic lymphocytes but is limited by rapid clearance and poor tumor retention. Here, we developed an oncolytic adenovirus encoding IL1...

Multisystem involvement in extramedullary plasmacytoma: diagnostic challenges and clinical implications—a case report

Extramedullary plasmacytoma (EMP) represents 3–5% of plasma cell tumors and is commonly found in the head and neck region, upper respiratory tract, and gastrointestinal tract. Cardiac and primary lung parenchymal involvement are extremely rare. This case report describes an unusu...

Lactate drives maladaptive metabolic reprogramming via MRS2 in ischemia/reperfusion-induced acute kidney injury

Ischemia/reperfusion (I/R) triggers profound bioenergetic collapse in renal proximal tubular epithelial cells (PTECs), inducing acute kidney injury (AKI) and forcing a sustained shift from mitochondrial oxidative metabolism to glycolysis. Lactate accumulation is a hallmark of thi...

B3GNT3 defines a spatially restricted dysfunctional T-cell niche and predicts immunotherapeutic outcomes in lung adenocarcinoma

Abstract Background Immunotherapy response in lung adenocarcinoma (LUAD) remains highly heterogeneous, underscoring the need for biologically informative markers of tumor immune dysregulation. B3GNT3, a glycosyltransferase implicated in several malignancies, is poorly characteriz...

Acute Kidney Injury During Vancomycin Treatment in Adult Patients With Haematologic Malignancies: A Multicentre Retrospective Study

ABSTRACT Background Acute kidney injury (AKI) during vancomycin treatment remains a rare occurrence in adult patients with haematological malignancies (HMs). The objective of this multicentre study was to investigate the incidence and risk factors for AKI during vancomycin treatm...

Global and regional brain-age gaps in primary trigeminal neuralgia: a cross-sectional structural MRI study of 133 anatomical structures

Primary trigeminal neuralgia (TN) is a severe craniofacial neuropathic pain disorder. Quantitative magnetic resonance imaging (MRI) studies suggest that TN-related alterations may extend beyond the trigeminal pathways. The brain-age gap (BAG) is MRI-predicted brain age minus chro...

Vibratory Characteristics and Quantitative Parameters of Laryngeal Dystonia: A Scoping Review of High‐Speed Videoendoscopy Studies

ABSTRACT Objective To review the clinical application and quantitative parameters of high‐speed videoendoscopy (HSV) in evaluating vocal fold kinematics in patients with laryngeal dystonia (LD), to summarize the limitations of existing studies, and to provide a reference for futu...

Risk factors and prevalence of incontinence-associated dermatitis in elderly patients: a meta-analysis and systematic review

This systematic review aimed to evaluate the prevalence and risk factors of Incontinence-Associated Dermatitis (IAD) in elderly patients. A systematic search was conducted across 10 databases, including PubMed, Embase, Web of Science, Cochrane Library, CINAHL, Ovid MEDLINE, Scopu...

Two-wave modified cardiometabolic index change patterns and incident edentulism in Chinese adults: a longitudinal study from CHARLS

Abstract Objectives Complete tooth loss is a late-stage oral health endpoint that may reflect cumulative oral, systemic, behavioral, and social risk processes. We examined whether two-wave patterns of the modified cardiometabolic index (MCMI) from 2011 to 2015 were associated wit...

Comparative efficacy of irrigation activation systems in root canal cleanliness: a region-specific analysis of debris and smear layer removal

This study aimed to compare the efficacy of four irrigation activation systems against conventional needle irrigation (CNI) in removing debris and smear layer from root canal. Forty human single-rooted teeth premolars were instrumented to a consistent size and randomly divided in...

Red blood cell distribution width and 28 days mortality in sepsis-associated delirium: a multicenter study and machine learning analyses

The specific prognostic relevance of red blood cell distribution width (RDW) regarding sepsis-associated delirium (SAD) remains poorly understood. Data were retrieved from the MIMIC-IV and eICU-CRD registries. Kaplan–Meier curves, multivariable Cox regression, restricted cubic sp...

Surface morphology, printing accuracy and flexural strength of 3D-printed zirconia posts with longitudinal microgrooves

Postcore restoration is essential for compromised teeth. Zirconia is a promising material due to its esthetics, strength, and radiopacity. Additive manufacturing, particularly advanced customized jetting (ACJ) technology, enables the fabrication of complex microstructures on zirc...