Institution
Zhongnan Hospital of Wuhan University
Recent research
- Health & Medicine
RNA-Binding Protein MBNL2 Drives Cardiac Hypertrophy and Dysfunction by Facilitating TPM3 Splicing
BACKGROUND: Cardiac hypertrophy is a major contributor to heart failure development, making its prevention and treatment critical for reducing heart failure–associated mortality. Although alternative splicing is recognized as a key regulatory mechanism in myocardial hypertrophy,...
- Engineering & TechnologyOpen access
ABSTRACT Impaired wound healing in diabetes is closely associated with cellular ferroptosis. Microneedle‐assisted gas therapy exerts molecular regulation of ferroptosis, representing a promising approach for accelerating diabetic wound healing. To date, O 2 and H 2 gas therapies...
- BiologyOpen access
ABSTRACT Ischemia/reperfusion (I/R)‐induced acute lung injury (ALI) is a severe clinical syndrome characterized by alveolar epithelial damage, oxidative stress, and acute respiratory failure, but the epitranscriptomic mechanisms linking N6‐methyladenosine (m6A) modification to fe...
- Health & MedicineOpen access
Targeted next-generation sequencing (tNGS) is increasingly used for pathogen detection in lower respiratory tract infections. However, real-world data on bronchoalveolar lavage fluid (BALF)-dominant tNGS findings in respiratory and critical care settings remain limited. This sing...
- Health & Medicine
BACKGROUND: Available data indicate that people living with HIV (PLWH) have weaker humoral immune responses to COVID-19 vaccines compared to the general population. However, data on cellular immune responses in this group has yet to be established. METHODS: We searched the PubMed...
- BiologyOpen access
Abstract Background Urinary cell-free DNA (ucfDNA) holds promise for liquid biopsies, yet standardized preprocessing protocols are lacking. This study evaluated the impact of several preanalytical variables on ucfDNA quality: ethylenediaminetetraacetic acid (EDTA) concentration,...
- Health & Medicine
ABSTRACT Aims To assess glycemic outcomes across different age groups and explore factors associated with glycemic target achievement during 12‐months open‐source android artificial pancreas (AAPS) use among people with type 1 diabetes (T1D). Methods This study included people wi...
- BiologyOpen access
Abstract Dysregulation of long non-coding RNAs (lncRNAs) plays a significant role in the progression of hepatocellular carcinoma (HCC), yet many underlying mechanisms remain elusive. Recent studies have highlighted the critical importance of internal N 7 -methylguanosine (m 7 G)...
- Engineering & Technology
Abstract Fungal infections represent a significant global health threat, exacerbated by the scarcity of new therapeutic options, increasing drug resistance, and host toxicity. Sonodynamic therapy (SDT) offers a promising approach to overcoming antimicrobial resistance by enabling...
- BiologyOpen access
Abstract Biomolecular condensates are membraneless assemblies that concentrate proteins, nucleic acids, and other biomolecules into dynamic cellular compartments. Liquid-liquid phase separation (LLPS) is one important route by which such condensates form, particularly when multiv...
- AI & Computing
ABSTRACT Objective To evaluate harms reporting practices in placebo‐controlled randomized clinical trials (RCTs) of Chinese herbal medicine (CHM) formulas published in Quartile 1 (Q1) English‐language and Tier‐1 Chinese journals. Methods This systematic survey evaluated harms rep...
- Health & MedicineOpen access
Acute ischemic stroke elicits a robust inflammatory response within the brain. As one of the first peripheral immune cells to infiltrate the ischemic parenchyma, neutrophils show high heterogeneity and engage in complex crosstalk with resident brain cells. In this review, we firs...
- Health & MedicineOpen access
Glucuronide prodrug strategies may enhance target specificity and reduce the toxicity of PARP inhibitors, but no clinical evaluation has been performed. We evaluated TSL-1502, a novel glucuronide prodrug of a PARP inhibitor, in a randomized, open-label, phase 2 study at 28 sites...
- Biology
ABSTRACT Background Ferroptosis is a non‐apoptotic form of cell death driven by lipid peroxidation. Although elevated lipid peroxidation has been linked to respiratory epithelial injury, its role in allergic rhinitis (AR) remains unclear. Therefore, in this study, we aimed to ass...
- Materials & Energy
ABSTRACT Organic room‐temperature phosphorescence (RTP) materials hold great promise as bioimaging agents due to their long‐lived emission and high signal‐to‐background ratios. However, their application in physiological environments is often hampered by water‐induced quenching....
- Health & Medicine
Purpose: To evaluate whether prone-position computed tomography (CT) is associated with improved perioperative outcomes in patients undergoing prone percutaneous nephrolithotomy (PCNL) compared with conventional supine CT. Patients and Methods: This single-center retrospective st...
- Health & MedicineOpen access
Prognostic model for gastric cancer integrating immune biomarkers and machine learning approaches
Prognostication for advanced gastric cancer remains sub-optimal because conventional staging systems overlook systemic inflammation and tumour-immune contexture. We investigated whether incorporating routine immune biomarkers into machine-learning survival models improves risk st...