Zhongnan Hospital of Wuhan University

Iteratively DesignedPhospholipid-Targeted SupramolecularSonosensitizers for Precision Treatment of Pulmonary Infections

Abstract Fungal infections represent a significant global health threat, exacerbated by the scarcity of new therapeutic options, increasing drug resistance, and host toxicity. Sonodynamic therapy (SDT) offers a promising approach to overcoming antimicrobial resistance by enabling...

Biomolecular condensates as dynamic regulators of musculoskeletal homeostasis, disease, and therapeutic challenges

Abstract Biomolecular condensates are membraneless assemblies that concentrate proteins, nucleic acids, and other biomolecules into dynamic cellular compartments. Liquid-liquid phase separation (LLPS) is one important route by which such condensates form, particularly when multiv...

Inadequate Reporting of Harms in RCTs of Chinese Herbal Medicine Formulas: A Systematic Survey of Leading Medical Journals

ABSTRACT Objective To evaluate harms reporting practices in placebo‐controlled randomized clinical trials (RCTs) of Chinese herbal medicine (CHM) formulas published in Quartile 1 (Q1) English‐language and Tier‐1 Chinese journals. Methods This systematic survey evaluated harms rep...

Neutrophil heterogeneity and crosstalk with cerebral-resident cells: therapeutic targets for ischemic stroke

Acute ischemic stroke elicits a robust inflammatory response within the brain. As one of the first peripheral immune cells to infiltrate the ischemic parenchyma, neutrophils show high heterogeneity and engage in complex crosstalk with resident brain cells. In this review, we firs...

Randomized phase 2 trial of a PARP inhibitor TSL-1502 in germline BRCA-mutated, HER2-negative locally advanced/metastatic breast cancer

Glucuronide prodrug strategies may enhance target specificity and reduce the toxicity of PARP inhibitors, but no clinical evaluation has been performed. We evaluated TSL-1502, a novel glucuronide prodrug of a PARP inhibitor, in a randomized, open-label, phase 2 study at 28 sites...

m6A ‐Related Regulation of Ferroptosis Contributes to Nasal Epithelial Barrier Dysfunction in Allergic Rhinitis

ABSTRACT Background Ferroptosis is a non‐apoptotic form of cell death driven by lipid peroxidation. Although elevated lipid peroxidation has been linked to respiratory epithelial injury, its role in allergic rhinitis (AR) remains unclear. Therefore, in this study, we aimed to ass...

Physiologically Robust Ultralong Aqueous Phosphorescence With Quantitative Hypoxia Sensing Through Hydrophobic‐Hydrophilic Engineering

ABSTRACT Organic room‐temperature phosphorescence (RTP) materials hold great promise as bioimaging agents due to their long‐lived emission and high signal‐to‐background ratios. However, their application in physiological environments is often hampered by water‐induced quenching....

Prognostic model for gastric cancer integrating immune biomarkers and machine learning approaches

Prognostication for advanced gastric cancer remains sub-optimal because conventional staging systems overlook systemic inflammation and tumour-immune contexture. We investigated whether incorporating routine immune biomarkers into machine-learning survival models improves risk st...

Prone CT Is Associated With Improved Safety and Stone-Free Outcomes in Prone PCNL: A Propensity-Matched Comparative Study

Purpose: To evaluate whether prone-position computed tomography (CT) is associated with improved perioperative outcomes in patients undergoing prone percutaneous nephrolithotomy (PCNL) compared with conventional supine CT. Patients and Methods: This single-center retrospective st...