Zhongnan Hospital of Wuhan University

Follistatin-Like Protein 1 Contributes to Acute Traumatic Spinal Cord Injury by Enhancing Neuroinflammation Through the Modulation of Interferon Regulatory Factor 5-Mediated Macrophage Activation

Background and Purpose: Follistatin-like protein 1 (Fstl1) is a secreted glycoprotein with context-dependent inflammatory activity. We investigated whether Fstl1 is a reproducible feature of traumatic spinal cord injury (SCI) and whether it regulates macrophage activation through...

MD ‐1 Deficiency Mitigates Atherosclerosis by Inhibiting NLRP3 Inflammasome Activation via cGAS ‐ STING Dependent Pathway in Macrophages

ABSTRACT MD‐1 plays significant roles in various pathological processes closely associated with cardiovascular diseases through its functions in different cell types. However, the critical effects and molecular mechanisms mediated by MD‐1 in macrophages involved in the developmen...

Development and validation of a clinical nomogram to predict prostate cancer in men with gray-zone PSA

This study aimed to develop and validate a novel nomogram for predicting prostate cancer in patients with gray-zone prostate-specific antigen (PSA), thereby reducing unnecessary prostate biopsies. Clinical data were retrospectively collected from patients who underwent prostate b...

Structural and Mechanistic Insights Into GSDME Pore Formation and Functional Regulation

ABSTRACT Gasdermin E (GSDME) is a unique member of the gasdermin family linked to deafness, cancer, and neurodegenerative diseases, and mediates chemotherapy‐induced pyroptosis; however, its pore‐forming mechanism remains poorly understood. Here, we present cryo‐EM structures of...

Service-continuity-oriented assessment and closed-loop governance of compound flood-season risk at a piedmont hospital in Beijing

Abstract Healthcare facilities in piedmont transition zones can be exposed simultaneously to slope instability, hillslope runoff, local waterlogging, access disruption, and lifeline failures during extreme rainfall. This study examines a specialized kidney hospital in Beijing and...

AI-assisted discovery of an ABCA1/ABCG1 activator for restoring mitophagy and mitigating Alzheimer’s pathology

Abstract Defective mitophagy is a key pathological risk of Alzheimer’s disease (AD), yet available pharmacological agents capable of restoring mitophagy remain clinically limited, largely due to the lack of tools for drug screening and target identification. To address this, we i...

Actin‐Related Causes of Aneuploidy in Human Eggs

Gametogenesis (oogenesis and spermatogenesis) relies on a specialized form of cell division known as meiosis. During this process, chromosomes in parental cells undergo two successive rounds of segregation, resulting in a halving of their number and the formation of haploid germ...

Recent advances in Ganoderma lucidum-derived bioactive components for cancer therapy

Abstract Ganoderma lucidum has attracted increasing attention in cancer research because of its diverse bioactive components and immunomodulatory properties. However, its antitumor effects are often discussed as broad “anticancer activity”, which may obscure the distinct roles of...

Osteoimmune sequence reprogramming: staged triboelectric immunotherapy for chronic osteomyelitis via JAK2–STAT3 regulation

Chronic osteomyelitis remains difficult to eradicate because persistent bacterial colonization is associated with disruption of the osteoimmune temporal sequence linking antibacterial immunity, inflammatory resolution, and bone regeneration. Here, a drug-free staged triboelectric...

Core-shell Au@HOF nanoradiosensitizers activate potent immunogenic cell death for enhanced radio–radiodynamic–immunotherapy

Radiotherapy (RT) efficacy is constrained by inefficient radiation utilization and inadequate systemic immunity. Although nanoparticle-based radiosensitizers aim to enhance therapeutic outcomes, most existing systems lack effective integration of radiation enhancement, dynamic th...

A novel FUT1 mutation c.268G>A ( p.Gly90Ser ) associated with the para‐Bombay B blood phenotype

The authors have disclosed no conflicts of interest. The data that support the findings of this study are available from the corresponding author upon reasonable request.

Novel mTORC1 Booster LAPTM4A Potentiates Pathological Cardiac Hypertrophy

BACKGROUND: Excessive unnecessary protein accumulation in cardiomyocyte is a leading contributor for pathological cardiac hypertrophy and has been found closely regulated by the mTORC1 (mechanistic target of rapamycin complex 1) signaling and lysosome transmembrane proteins. Howe...

Gut microbiome mediates the protective effects of empagliflozin on experimental abdominal aortic aneurysm formation and progression

Abdominal aortic aneurysm is a life-threatening vascular disease lacking effective pharmacotherapies. This study aimed to investigate the protective effect of empagliflozin, a sodium-glucose cotransporter 2 (SGLT-2) inhibitor, against angiotensin II (AngII)-induced AAA in ApoE −/...

Radiotherapy and immunotherapy for oligometastatic hepatoid adenocarcinoma arising from endometriosis: a case report

Abstract Objectives Hepatoid adenocarcinoma (HAC) arising from endometriosis is an extremely rare malignancy with a poor prognosis and no standard treatment. Radical surgical resection followed by chemotherapy is the commonly used treatment for HAC. The role of radiotherapy and i...

Porcine Sertoli cell exosomes tune the redox setpoint of spermatogonial stem cells through PSMD11–p38 MAPK signaling to mediate differentiation

Spermatogonial stem cell (SSC) fate—the choice between self-renewal and differentiation—is governed by intercellular signaling within the testicular niche. A central paradigm holds that endogenous reactive oxygen species (ROS) sustain SSC self-renewal through MAPK signaling. Yet...

Targeted degradation of RAGE restores microglial homeostasis and rescues cognitive deficits in 3xTg-AD mice

Chronic neuroinflammation and microglial dysfunction lie at the core of Alzheimer’s disease (AD) pathogenesis. The Receptor for Advanced Glycation End-products (RAGE) serves as a pivotal upstream driver of this inflammatory cascade and associated oxidative stress. However, conven...

Library strategies differentially shape microbial, functional, and host signals in clinical metagenomic sequencing

Metagenomic next-generation sequencing (mNGS) is increasingly used in infectious disease diagnostics, yet how library preparation shapes the microbial, functional, and host signals recovered from clinical samples remains poorly defined. Here, we performed a within-sample parallel...

Gallstone formation and hepatobiliary tumour risk: Clinical implications of the bile acid–gut microbiota axis

Abstract Background Gallstones affect approximately 6%–15% of adults worldwide and represent a common condition that also serves as a risk factor for hepatobiliary malignancies. Conventional ultrasound cannot provide early warning during the early metabolic phase before crystalli...

Directed biosynthesis of the designer peptidyl nucleoside antibiotics featuring a simplified azetidine-containing moiety

Fungal and fungal-like pathogen infections pose escalating threats to the global one-health, thus underscoring the urgent need to reverse this trend by accelerating the development of novel antifungal drugs. Polyoxin (POL), a group of structurally related nucleoside antibiotics,...

RNA-Binding Protein MBNL2 Drives Cardiac Hypertrophy and Dysfunction by Facilitating TPM3 Splicing

BACKGROUND: Cardiac hypertrophy is a major contributor to heart failure development, making its prevention and treatment critical for reducing heart failure–associated mortality. Although alternative splicing is recognized as a key regulatory mechanism in myocardial hypertrophy,...