Zhengzhou Children's Hospital

Laparoscopic−assisted versus purely transanal Soave procedures for Hirschsprung disease in children aged ≤ 4 years: an age−stratified retrospective study

Laparoscopic−assisted and purely transanal Soave procedures are commonly used for Hirschsprung disease, but whether their comparative outcomes differ according to age remains uncertain. This single−center retrospective cohort study included 188 children aged ≤ 48 months who under...

Engineered Allosteric Biosensor for In Situ DNA Glycosylase Detection in Neuroblastoma Risk Stratification and Drug Resistance Monitoring

ABSTRACT Accurate and in situ detection of uracil‐DNA glycosylase (UDG) is crucial for clinical diagnosis and prognosis assessment. However, conventional methods show low accuracy, limited sensitivity, and off‐target signal leakage due to flawed signal input/output and amplificat...

Association between thyroid function profiles and malnutrition severity in elderly patients

Aim To explore the of triiodothyronine (rT3) in the prognostic model of malnutrition in the elderly. Methods A total of 166 elderly patients with malnutrition were included in the experimental group, and 98 healthy people were collected as the control group. The six thyroid funct...

Protein 4.1 R Suppresses Melanoma Progression by Inhibiting Glycolysis via the PI3K/AKT/mTOR Pathway

ABSTRACT Melanoma is a highly aggressive malignancy with strong metastatic potential. Protein 4.1 R, encoded by EPB41 , is a membrane cytoskeleton protein that plays an essential role in maintaining plasma membrane stability and cytoskeletal organization. Recent studies have indi...

Exploratory early-warning modeling of in-hospital mechanical intestinal obstruction after kasai portoenterostomy in children with biliary atresia

Mechanical intestinal obstruction during hospitalization after Kasai portoenterostomy for biliary atresia (BA) is uncommon but clinically important. Because event numbers are limited and early manifestations overlap with postoperative ileus, this retrospective study aimed to iden...

Comprehensive genomic characterization of extraintestinal pathogenic Escherichia coli isolated from neonates: multiple center insights into virulence, resistance, and transmission dynamics

Neonatal extraintestinal pathogenic Escherichia coli (ExPEC), which can cause severe long-term sequelae by systemic infections, is gradually becoming the primary pathogen threatening neonatal health. The lack of large-scale genomic epidemiological investigation hinders further un...