Zhejiang Lab

Large tunneling magnetoresistance in room temperature magnetic tunnel junctions based on altermagnetic XV2Y2O

This work presents a comprehensive investigation of spin-dependent quantum transport properties of the emerging layered room temperature metallic altermagnet family X V 2 Y 2 O ( X = K, Rb, Cs; Y = S, Se, Te), based on first-principles calculations combined with the non-equilibri...

Targeted NAD + Metabolic Reprogramming Enables Functional Endometrial Regeneration and Fertility Restoration in Intrauterine Adhesions

ABSTRACT Regeneration of the injured endometrium requires re‐establishment of a permissive microenvironment that supports coordinated epithelial renewal, angiogenesis, and matrix remodeling. However, this regenerative transition remains incomplete in intrauterine adhesions, sugge...

Towards Optimal Speculative Decoding: A Comprehensive Survey on Optimizations and Future Directions

Speculative decoding (SD) has emerged as a compelling approach to breaking the sequential bottleneck of autoregressive large language model (LLM) inference. By coupling lightweight drafting with parallel verification, SD reduces expensive target-model decoding while preserving ge...

Deep learning radiomics based on preoperative multiparametric MRI in predicting breast cancer recurrence risk

Breast cancer treatments are often tailored to recurrence risk to improve outcomes, but reliable risk stratification methods are lacking. To predict preoperative breast cancer recurrence risk through a tridimensional synergy model integrating breast MRI, radiomics, and deep learn...

Geometrical-optics resonator photonics

Conventional waveguide optical resonators face inherent limitations of low damage thresholds, limited coupling tunability, and stochastic resonance. To overcome these, we introduce a geometrical-optics resonator (GOR) framework, emulating free-space reflection and thin-film coupl...

Ultrasound-mediated mechanical force perturbing plasma membrane properties for paclitaxel-resistant epithelial ovarian cancer therapy

Abstract Paclitaxel (PTX) resistance in epithelial ovarian cancer (EOC) is a significant clinical challenge, often resulting in cross-resistance to other chemotherapeutic agents and contributing to a low five-year survival rate. In recent years, the physical characteristics of tu...

Knowledge graph-enhanced large language models toward reliable elevator fault diagnosis

The operational reliability of elevator systems is critical for the safety and efficiency of modern urban infrastructure. While large language models have demonstrated exceptional reasoning capabilities, their application to specialized industrial maintenance tasks is constrained...

Carbonation of calcined Red Mud: Multifactor influences, reaction mechanism and environmental impact assessment

Red mud (RM) is a bulk alkaline solid waste generated by the alumina industry, carbonation can achieve alkalinity reduction and carbonation in red mud. However, its low reactivity limits further utilization. This study systematically investigates the effect of calcination modific...

Buried fragments reveal a “Greater Gondwana” supercontinent

Profound global biogeochemical shifts marked the Ediacaran-Cambrian transition [550–500 million years (Ma)], a phenomenon often ascribed to the dynamics of supercontinent cycles. However, Gondwana is frequently denied supercontinent status due to its perceived spatial deficit (∼6...

Reinforcement Learning-Assisted Quantum Simulation of Many-Body Excited States and Real-Time Dynamics

Abstract The computation of electronic excited states and real-time quantum dynamics of many-Fermion systems is among the most promising applications of near-term quantum computing. In this work, we generalize the reinforcement learning contracted quantum eigensolver (RL-CQE), pr...

ERK-dependent hyperexcitability of BLA neurons projecting to dCA3 underlies social dysfunction in a male mouse model of fragile X syndrome

Background Social dysfunction is a core symptom of autism spectrum disorder (ASD), including fragile X syndrome (FXS), but its underlying neural circuits and molecular mechanisms remain poorly understood. Previous studies have implicated the amygdala and hippocampus in social beh...

Hyperactive lateral hypothalamic GABAergic neurons drive abnormal aggression in neuroligin-3 R451C knock-in mice

Aggressive behaviors represent a common and clinically challenging comorbidity in individuals with autism spectrum disorder (ASD), yet the underlying neural mechanisms remain poorly understood. This study aimed to investigate the circuit-level pathology driving elevated aggressio...

A Hybrid CNN-Transformer Network for Linear Noise Suppression in 3D Seismic Data

Abstract 3D seismic data acquisition, processing, and analysis have become increasingly prevalent in modern geophysical exploration. However, various types of coherent noise, especially linear noise, can cause serious interference and effective noise reduction techniques are crit...

Plasma FGF23 and cardiovascular mortality in relation to kidney function among adults with established cardiovascular disease

Fibroblast growth factor-23 (FGF23) has been linked to adverse cardiovascular phenotypes, yet its prognostic relevance among individuals with prevalent cardiovascular disease and the potential modifying role of kidney function remain unclear. We analyzed 9,119 UK Biobank particip...

Dignified Death in China：Dilemmas and Reflections.

The implementation of dignified death in China faces multiple practical obstacles.Economic conditions，resource allocation，cultural values and other social factors profoundly shape different groups' understanding and implementation of dignified death.Against this background，the...

Heat stress enhances gut microbial arginine catabolism to amplify MyD88-dependent inflammatory responses

As global temperatures continue to rise, heat stress (HS) has emerged as a major health threat of growing concern. HS triggers systemic inflammation and multi-organ damage, but so far its molecular mechanisms remain unclear. In this study, we explored the potential mechanism by w...

Active Learning‐Accelerated Discovery of Antifungal Polymers With Self‐Assembly Capacity for Tackling Invasive Fungal Diseases

ABSTRACT Invasive fungal diseases (IFD) are life‐threatening infections with limited clinical management. Antifungal peptide (AFP)‐mimicking polymers are promising candidates for tackling IFD. However, due to the structural diversity of polymers, it remains a great challenge to d...

Application effect of flipped classroom combined with SNAPPS teaching model in emergency medicine interns

Abstract Objective To explore the application value of flipped classroom (FC) combined with SNAPPS teaching framework in emergency department clinical teaching for medical interns. Methods In this randomized controlled trial, a total of 104 fifth-year undergraduate medical intern...

Metabolic-pathway-based classification of tendinopathy reveals a precise therapeutic strategy targeting chondro-modulatory tenocytes

Abstract Tendinopathy is a prevalent degenerative condition driven by complex metabolic dysregulation, yet its inherent metabolic heterogeneity remains poorly characterized, hindering targeted therapeutic development. To address this, we performed systematic multi-omics profiling...

Self-locking non-volatile coding metasurfaces via origami-based mechanical bits

Digital coding metasurfaces have revolutionized electromagnetic (EM) manipulation, yet typical tunable approaches based on active components suffer from “volatility”. While mechanical modulation provides a potential solution, current implementations generally lack inherent state-...