Zhejiang Lab

Molecular Basis for Activation to Inhibition Switching in Kv7.2 Channel Modulators

ABSTRACT Kv7 voltage‐gated potassium channels play a critical role in controlling electrical properties of excitable tissues. Neuronally‐expressed Kv7 channels are involved in both common and rare neuropsychiatric disorders, ranging from epilepsy to depression and neurodegenerati...

From graph Laplacian to ring polymer dynamics: part I

Abstract A graph-theoretic formulation of overdamped Langevin dynamics and constitutive equations for ring polymers is developed. The polymer molecule is represented as a bead–spring network whose connectivity is described by a graph Laplacian. Starting from overdamped stochastic...

Development of a Milli-Kelvin Thermostatic Bath for High-Precision Temperature Sensor Calibration

For most temperature sensors, measurement traceability must be established via a comparison method within a thermostatic environment. To address the limitations of domestic constant temperature baths in meeting the calibration requirements for high-precision temperature sensors i...

AI-Guided Discoveryof Natural-Product-Inspired Scaffoldsas Dual P-gp/BCRP Inhibitors to Overcome Cancer Multidrug Resistance

Abstract ATP-binding cassette (ABC) transporters ABCB1/P-glycoprotein (P-gp) and ABCG2/breast cancer resistance protein (BCRP) drive multidrug resistance (MDR) by limiting intracellular chemotherapy accumulation, and are coexpressed in cancers with overlapping substrates. Here, w...

Optimal Transport-Based Heterogeneous Federated Learning for Chest X-Rays

In some federated learning (FL) scenarios, discrepancies in local client devices result in inconsistent image resolutions, which motivates clients to adopt models with different depths and widths. Existing heterogeneous federated learning methods struggle to maintain model accura...

Temporal Multi-Omics Reveals Microbial and Metabolic Succession Following Astilbin Treatment in a Human Colonic Model

Background: Astilbin is a bioactive flavonoid with documented anti-inflammatory properties; however, its sustained interactions with the gut microbiota remain poorly understood. Fecal samples from three healthy donors were pooled and fermented with astilbin in an in vitro human c...

Silicon-Based Highly c -Axis-OrientedStrontium Barium Niobate Films with Large Pockels Coefficients

Abstract To develop a new generation of high-performance silicon-based electro-optic modulators, it is necessary to find an electro-optic crystal with a simple fabrication process, stable chemical properties, and large Pockels coefficients, such as strontium barium niobate (SrxBa...

Shape‐based sieving of hexane isomers in liquid‐phase by a scalable metal–organic framework

Abstract The separation of mono‐ and di‐branched alkane isomers is an industrially important yet highly challenging process requiring precise pore structures. Here, we report a scalable metal–organic framework, Ni 3 (H 1.5 BTC) 2 (BTC)(DABCO) 3 (denoted as Ni‐HDB), featuring an a...

Narrowband Hydrocarbon Emitters Enabled by Stereo‐Locked Through‐Space Interactions

ABSTRACT High‐purity emitters with a narrowband emission are a critical requirement for next‐generation displays and lighting, yet it remains a formidable challenge for purely organic materials, particularly in the pure‐violet region. Herein, a general molecular design strategy b...

Narrowband Hydrocarbon Emitters Enabled by Stereo‐Locked Through‐Space Interactions

ABSTRACT High‐purity emitters with a narrowband emission are a critical requirement for next‐generation displays and lighting, yet it remains a formidable challenge for purely organic materials, particularly in the pure‐violet region. Herein, a general molecular design strategy b...

Research on Mechanism of Fatigue Life Enhancement in Ball Bearings by Residual Compressive Stress

While the beneficial effect of residual compressive stress (RCS) on rolling bearing fatigue life is empirically well-established, the underlying mechanisms, particularly its influence on the subsurface stress field responsible for fatigue initiation, remain inadequately explored....

“Jun-Chen-Zuo-Shi” - the Chinese medical perspective on clinical oncology nutritional therapy

Abstract Cancer-associated malnutrition and cachexia are common, clinically consequential syndromes that compromise treatment tolerance, increase postoperative and therapy-related complications, diminish quality of life, and shorten survival. Nutritional therapy is therefore incr...