Zealand University Hospital

Bivalent RSV Prefusion F Vaccine to Prevent Hospitalizations in Adults

BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of severe respiratory disease in adults, with the highest burden among older adults and individuals with chronic health conditions. The bivalent RSV prefusion F (RSVpreF) vaccine has been shown to prevent RSV-ass...

Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis

BACKGROUND: In patients with infective endocarditis on the left side of the heart, the current recommendation of up to 6 weeks of antibiotic therapy is based largely on expert consensus opinion. Whether a clinical response-tailored antibiotic management strategy can shorten treat...

Lessons from the Danish Vascular (DanVasc) pilot survey: patient-reported outcomes following lower extremity, carotid and aortic artery disease

Patient-reported outcomes are insufficiently studied across the three predominant vascular diseases: lower extremity artery disease (LEAD), symptomatic carotid stenosis (SCS) and abdominal aortic aneurysm (AAA). To address this gap, the Danish Vascular (DanVasc) survey was develo...

Hunger pain and its reduction; qualitative insight from people with schizophrenia on semaglutide

PURPOSE: It is often reported that people with schizophrenia experience weight gain and disordered eating, partly due to antipsychotics. As part of the RCT "Home-based Intervention with Semaglutide Treatment of Neuroleptic-Related Prediabetes, HISTORI", the present study investig...

Inter-Rater Agreement in PD-L1 (22C3) Expression Evaluation in Colon Cancer

Programmed death-ligand 1 (PD-L1) is a predictive biomarker in various cancers. In colorectal cancer, PD-L1 expression evaluation is not part of the routine examination and standardized evaluation methods are lacking. This study aimed to examine inter-rater agreement in PD-L1 exp...

Rehabilitation After Stroke in a Transition From Hospital to Municipality—Impact of Amount of Rehabilitation

ABSTRACT Background Stroke is a leading cause of long‐term disability that impairs physical function and health‐related quality of life (HRQoL). Rehabilitation during and after hospitalization is essential for promoting neurological recovery and functional independence. This stud...

Transthoracic drainage of lung abscesses (TOLA): protocol for a national multicenter randomized open-label trial

Introduction Lung abscess (LA) is a rare but severe necrotizing pulmonary infection associated with substantial morbidity and mortality. Current management relies on prolonged systemic antibiotic therapy without systematic use of abscess drainage. However, small case series and r...

Blood Pressure Targets During General Anaesthesia in High‐Risk Patients—A Randomised Clinical Feasibility Trial

BACKGROUND: There is limited high-quality evidence to guide haemodynamic and respiratory management during general anaesthesia. The goal of this trial was to test the feasibility of testing different ventilatory settings and blood pressure targets. Previous trials on blood pressu...

Exercise training during hospitalization in community-acquired pneumonia: effects on functional ability, body composition, and physical activity level

Abstract Background Physical inactivity contributes to functional decline and is associated with increased risk of adverse outcomes in patients hospitalized with community-acquired pneumonia (CAP). Exercise programs applied during acute hospitalization may mitigate these effects,...

Severity and resource utilisation among trauma patients undergoing trauma team activation in four Danish trauma units: a prospective cohort study

Evidence on trauma epidemiology and outcomes largely originates from major trauma centres, while data from regional trauma units remain limited. The aim of this study was to describe the epidemiology, management, and outcomes of patients undergoing trauma team activation in the t...

Patients’ experiences of living with the risk of Alzheimer’s disease – a multicentre qualitative study

Aims and objectives To explore the experiences of receiving and living with a diagnosis of prodromal Alzheimer’s disease. Background Alzheimer’s disease is a progressive dementia disorder, with pathology potentially developing years before clinical symptoms. Evidence concerning p...

Factors Associated With Progression From Level 1 to Level 2 Sensor‐Detected Hypoglycaemia in People With Type 1 and Insulin‐Treated Type 2 Diabetes: A Post Hoc Analysis From the Hypo‐ METRICS Study

ABSTRACT Aims We investigated the proportion of sensor‐detected hypoglycaemic (SDH) events progressing to level 2, and associated variables. Materials and Methods We used data from Hypo‐METRICS, which recruited people with type 1 (pwT1D) and insulin‐treated type 2 diabetes (pwT2D...

Predicting future risk of type 1 and type 2 diabetes after gestational diabetes mellitus using polygenic scores: a cohort study

AIMS/HYPOTHESIS: Women with previous gestational diabetes mellitus (GDM) have an increased risk of developing both type 1 and type 2 diabetes. However, predicting the risk on a personal level is challenging. Polygenic scores (PGSs), which capture an individual's genetic susceptib...