Yunnan University of Traditional Chinese Medicine

A self-assembled Dendrobium polysaccharide hydrogel with anti-aging activity via the FOXO signaling pathway

Faced with the complexity and diversity of skin aging, it is critical to investigate multi-target synergistic anti-aging products. Herein, a novel composite hydrogel with anti-aging activity was developed based on Dendrobium polysaccharide, hyaluronic acid (HA), and nicotinamide...

Application of symptom network analysis among patients with gastric cancer: A scoping review

Objective To map evidence on symptom network analysis in patients with gastric cancer by summarizing study characteristics, commonly used assessment tools, central and bridge symptoms, temporal symptom relationships, and associated factors, and to provide a basis for precision sy...

Ellagic Acid Enhances RSL3 ‐Induced Ferroptosis by Inhibiting the Nrf2/ HO ‐1 Signaling Pathway in Pancreatic Ductal Adenocarcinoma

Pancreatic ductal adenocarcinoma (PDAC) exhibits profound therapeutic resistance due to redox adaptation, particularly through Nrf2/HO-1 pathway activation. Ferroptosis induction via GPX4 inhibitors (e.g., RSL3) is promising but limited by adaptive antioxidant responses. Ellagic...

ALOX15-Inhibitory Peptides Derived from Coffee Bean Protein Hydrolysates Confer Neuroprotection against Lipid Peroxidation

Abstract Coffee beans are widely consumed worldwide and are known for their central nervous system-stimulating effects, mainly attributed to caffeine and other small molecules. However, the neuroprotective potential of coffee bean-derived peptides remains largely unexplored. In t...

Cannabis sativa L. juice as a novel functional drink ameliorates hyperlipidemia by inhibiting lipid synthesis and oxidative stress

Hyperlipidemia is a major public health concern due to its increasing global prevalence. Hemp seed ( Cannabis sativa L. seed) is a medicinal plant that has gained attention for its potential applications under the “homology of medicine and food” framework. Previous studies sugges...

Acupuncture alleviates the progression of lumbar disc herniation by regulating the autophagy level of nucleus pulposus cells through the SIRT1/Sestrin2 pathway.

BACKGROUND AND PURPOSE: Lumbar disc herniation (LDH) is a degenerative spine disease and the most common cause of lower back pain, with a high prevalence in younger patients. The use of acupuncture (AC) as a conservative treatment for LDH has received widespread attention at home...

Insights into the relationship between menopausal timing and risk of cardiovascular disease: a systematic review and meta-analysis of Mendelian randomization analyses

Cardiovascular disease (CVD) is the leading cause of death and imposes a substantial burden on women’s health. Early onset of menopause, as a unique trait of reproductive aging, has been associated with a higher risk of adverse cardiovascular events in traditional observational s...