Yueyang Hospital

Oral nonpeptide GLP-1 receptor agonist VCT220 for obesity treatment: a randomized, double-blind, phase II trial

VCT220 is a novel nonpeptide, orally available glucagon-like peptide-1 receptor agonist (GLP-1RA) designed to reduce the complex administration of injectable GLP-1RAs and the limited bioavailability of on-marketing oral agents for obesity care. We conducted a multicenter, randomi...

Optimization of the Sequence of Computed Tomography Angiography and Perfusion in One-Stop-Shop CT Imaging for Acute Ischemic Stroke

Background:In the "one-stop-shop" stroke computed tomography (CT) scanning protocol, CT perfusion (CTP) can be performed either before or after CT angiography (CTA).This study analyzed the effect of different scanning strategies in one-stop-shop stroke CT on CTA image quality and...

Development and external validation of a machine learning model for early identification of hypotension associated with renal replacement therapy in ICU patients

Renal replacement therapy (RRT) is essential for critically ill patients in the intensive care unit (ICU), yet hypotension remains its most common complication, increasing the risk of organ hypoperfusion and poor outcomes. No reliable tool currently exists to predict hypotension...

A dual role of PIEZO2 in neuropathic pain: driving peripheral sensitization and enabling mechanical loading-induced analgesia

Mechanotherapy, a form of mechanical loading (ML), effectively relieves tactile allodynia-associated neuropathic pain by targeting sensitization points stimulated by PIEZO2, a mechanosensitive ion channel. However, the molecular mechanisms underlying peripheral sensitization and...

Hierarchical ROS-scavenging hydrogel system for coordinating the modulation of RGC necroptosis and oxidative stress in an acute glaucoma model

Glaucoma, a leading cause of irreversible blindness, is characterized by the progressive loss of retinal ganglion cells (RGCs). Beyond intraocular pressure (IOP)-dependent injury, IOP-independent pathways, specifically the self-amplifying axis between oxidative stress and the nec...

Prognostic model for gastric cancer integrating immune biomarkers and machine learning approaches

Prognostication for advanced gastric cancer remains sub-optimal because conventional staging systems overlook systemic inflammation and tumour-immune contexture. We investigated whether incorporating routine immune biomarkers into machine-learning survival models improves risk st...