Yangzhou University

Polygenic risk score analysis for major depressive disorder in a Chinese cohort: single-phenotype and pathway-based approaches

Abstract Background Major depressive disorder (MDD) is a global mental health challenge characterized by high prevalence, disability, and recurrence, with its susceptibility showing substantial polygenic inheritance. Polygenic risk scores (PRS) provide a novel method to explore c...

Integrative Analysis of the Metabolome and Transcriptome Reveals the Mechanism Underlying Differences in Skin Development Between the New Zealand Rabbit and the Rex Rabbit

Rex rabbit fur is a high-value material in the textile industry; however, the integrated metabolomic and transcriptomic mechanisms underlying differences in fur traits between fur-type Rex rabbits and meat-type New Zealand White rabbits remain incompletely understood. In this stu...

Fecal Microbiota Transplantation in Dogs and Cats: Evidence for Gastrointestinal and Emerging Extra-Intestinal Applications

Fecal microbiota transplantation (FMT) is an emerging microbiome-directed intervention for dogs and cats, but its clinical role remains incompletely defined. This structured narrative review integrates peer-reviewed clinical, mechanistic, methodological, and safety evidence on co...

Suaeda salsa: stress adaptation, soil restoration, and agronomic potential in salt-affected environments

Suaeda salsa is a widely distributed annual euhalophyte that thrives under both saline and saline-alkaline conditions, making it a valuable model for understanding plant salt-tolerance mechanisms and a promising resource for saline agriculture. However, the integrated understandi...

Molecular Characterization of Listeria monocytogenes Isolated from Retail Yak Meat in Nyingchi, Xizang, China

Listeria monocytogenes is a Gram-positive zoonotic pathogen responsible for listeriosis, a severe foodborne disease with high mortality in humans and animals. This study aimed to investigate the molecular epidemiology and genomic characteristics of L. monocytogenes isolated from...

CBAM-YOLOv11 and Geometric Constraint-Enhanced PnP for High-Precision EV Charging Port Pose Estimation

The precise detection and pose estimation of electric vehicle (EV) charging ports in unstructured outdoor environments remain challenging due to small sizes, variable illumination, and stringent tolerance requirements for robotic plug-in operations. To address these issues, this...

Integrative GWAS, eQTL, and functional validation identify ZNF280B as a key regulator of growth and carcass traits in Hu sheep

Abstract Hu sheep are a well-known Chinese dual-purpose breed valued for meat production, early sexual maturity, high prolificacy, and adaptability to hot, humid environments. In this study, we combined whole-genome sequencing, GWAS, and eQTL analyses to investigate the genetic b...

The Transmission Properties and Dynamical Characterization Driven by the Flat Bands in a Non‐Hermitian Dimerized Lattice

ABSTRACT A method of Fourier transform engineering is demonstrated to constructing flat bands in a two‐band model. By introducing a momentum‐dependent pseudo‐‐symmetry potential into a generalized Su–Schrieffer–Heeger model, we generate two momentum‐independent flat bands. The co...

DeepPoseCare: a privacy-preserving pose-based temporal convolutional framework for real-time patient action recognition in healthcare environments

Continuous and automated surveillance of patient activities in clinical environments holds great promise for the early identification of falls and distress in patients. However, current vision-based systems face obstacles such as privacy issues, the need for real-time processing,...

A New Prediction Method of the Constitutive Stress–Strain Relationship for Stainless Steel–Clad Bimetallic Steel Bars

Abstract Stainless steel–clad bimetallic steel bars (SCBSBs) as composite structures exhibit complex stress–strain behavior due to dimensional and material heterogeneity, limiting engineering applications. This paper describes a novel approach to effectively predict the stress–st...

Ergothioneine-Derived Carbon Dot Nanozymes Alleviate the Oxidative Stress Microenvironment to Delay Intervertebral Disc Degeneration

Nucleus pulposus cells (NPCs) age mainly because reactive oxygen species (ROS) build up too much. Excess ROS is associated with intervertebral disc degeneration (IVDD). In this study, we prepared ergothioneine-derived carbon dots (EGT-Fe-CDs) as an antioxidant nanozyme. EGT-Fe-CD...

Metabolic profiling reveals spatially-distinct reprogramming of host central carbon metabolism during Trichinella spiralis infection

The metabolic interplay between Trichinella spiralis (Ts) and its host remains a critical but underexplored aspect of trichinosis pathogenesis. Understanding how the parasite manipulates host metabolism is key to developing new diagnostic and therapeutic strategies. We employed t...

A Validated, explainable machine learning–based preoperative risk model for microvascular invasion in hepatocellular carcinoma

Abstract Purpose This investigation aimed to develop and validate a diagnostic algorithm for preoperatively assessing the likelihood of microvascular invasion (MVI) in patients with hepatocellular carcinoma (HCC). Methods Clinical and pathological information of patients with HCC...

Age-related shifts of dissolved hydrogen and its impact on rumen fermentation dynamics and microbial communities in goats (Capra hircus)

Abstract The rumen is a complex anaerobic fermentation ecosystem in which microbial communities undergo dynamic changes during host development, influencing fermentation efficiency, hydrogen utilization, and methane (CH₄) production. However, how rumen maturation reshapes hydroge...

HSAR-DETR: Hierarchical Spatial–Frequency Attention Network for UAV Small Object Detection

Small object detection in UAV remote sensing imagery plays a crucial role in applications such as infrastructure inspection, disaster assessment, and precision agriculture, where targets of interest frequently occupy fewer than 32×32 pixels under large ground sampling distance va...

Manifold Regularized Nuclear Norm Matrix Group Sparse Classifier for Robust Image Classification

ABSTRACT Robust representation‐based image classification must cope with complex mixed degradations, including global structural variations (e.g., severe non‐linear illumination) and localized contiguous corruptions (e.g., block occlusions or disguises). While existing matrix‐bas...

Boosted Alkaline Oxygen Evolution Reaction via Phosphorus Incorporation in FeCoS2@MoS2 Core–Shell Heterostructures

Achieving sustainable energy conversion hinges on the rational design of oxygen evolution reaction (OER) electrocatalysts that deliver both high efficiency and low cost. Herein, we report a phosphorus-doped iron-cobalt sulfide/molybdenum sulfide heterostructure on nickel foam (P-...

SHP2 accelerated acute liver injury via modulating TGFβ1/EZH2/BRD4 signaling induced proliferation and fibrosis of HSC

To explore the specific molecular mechanisms by which SHP2 promotes liver injury. Single-cell transcriptomics and bioinformatics analyses were employed for predictive screening. C57BL/6J mice were assigned to normal, model, and model+PHPS1 groups. Liver injury and fibrosis were e...

Advancements in Intelligent Thawing Systems for Protein‐Based Foods: An Industry 5.0 Perspective

ABSTRACT Freezing is essential for maintaining the stability of the global supply chain for protein‐based foods such as meat and aquatic products. However, traditional thawing technologies suffer from low efficiency and severe quality deterioration. Aligned with the principles of...

Effects of weighted jump-squat set configuration on acute explosive performance and fatigue responses in resistance-trained men: a randomized crossover study

Weighted jump squats are commonly used to acutely enhance explosive performance, but the optimal organization of repetitions and rest intervals remains unclear. This study compared the effects of traditional, cluster, and rest-redistributed weighted jump-squat configurations on c...