XinHua Hospital

Multi-omics analysis identifies the super-enhancer-driven gene NPW in left-sided obstructive lesions-associated cardiac remodeling

Left-sided obstructive lesions (LSOLs), represented by coarctation of the aorta (CoA), cause persistent vascular pathology and pressure overload that can lead to pathological cardiac remodeling. However, the epigenetic changes associated with local vascular abnormalities and vent...

Digital therapeutics for mild adolescent idiopathic scoliosis: a protocol for a randomized controlled trial

Abstract Background Digital therapeutics (DTx), a new type of intervention presented in the last few years, can be used to provide patients with access to evidence-based therapeutic interventions using high-quality software programs to achieve the purpose of treating, managing, o...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

Acox2 deficiency induces cardiac dysfunction via cross-organ metabolic reprogramming in mice

Abstract Background Secondary cardiomyopathies are a major cause of heart failure (HF) with diverse etiologies and high mortality rates. For example, over 50% of patients with end-stage liver disease develop cardiac dysfunction, clinically termed cirrhotic cardiomyopathy (CCM). W...

Noninvasive Detection of MASH and Fibrotic Burden Using Ultrasound‐Derived LIID and LSM in MASLD: A Multicenter Study

ABSTRACT Background and Aims Metabolic dysfunction‐associated steatohepatitis (MASH), the progressive form of metabolic dysfunction‐associated steatotic liver disease (MASLD), is associated with adverse hepatic and cardiometabolic outcomes. The study aimed to validate a novel qua...

Metabolomic profiling reveals candidate discriminatory metabolites in stable chronic obstructive pulmonary disease and acute exacerbation

To characterize serum metabolic alterations across healthy controls, stable chronic obstructive pulmonary disease (SCOPD), and acute exacerbation of chronic obstructive pulmonary disease (AECOPD), and to explore candidate discriminatory metabolites for COPD-related comparisons. S...

Real-world evidence of self-managed weight loss enhancing skeletal muscle rate in individuals with overweight/obesity via mHealth app

Weight loss is essential for obesity management but may be compromised by skeletal muscle loss. This study evaluated the increase in skeletal muscle rate (SMR) and fat loss among individuals with overweight/obesity who achieved weight loss through self-management using a mobile h...

State-dependent reconfiguration failure of the basal forebrain-cortical gradient in Parkinson’s disease with freezing of gait

Accumulating evidence implicates cholinergic dysfunction in freezing of gait (FOG) in Parkinson’s disease (PD). Given the basal forebrain (BF) provides the primary cholinergic input to the cortex, elucidating BF-cortical connectivity and its dynamic reconfiguration during motor c...

Three-dimensional orientation changes of unerupted maxillary canines and second premolars treated with facemask therapy: a retrospective study

Tooth-borne facemask therapy for skeletal Class III malocclusion is often performed during the mixed dentition, when the maxillary canines and second premolars are still developing. Although the appliance advances the maxilla, it also produces dentoalveolar side effects that coul...