XinHua Hospital

Bilateral lower limb dysfunction due to acute hematoma in the lumbar ligamentum flavum

Rationale: There have been several reports of lumbar yellow ligament hematomas leading to cauda equina and/or nerve root compression. However, based on clinical history and histological findings, most of these cases involve chronic hematomas. Acute lumbar yellow ligament hematoma...

PD-L1-Targeted and ROS-Responsive Nanoplatform for Simultaneous Chemotherapy and Dual-Modal Imaging of Treatment Response in Triple-Negative Breast Cancer

Abstract The evaluation of treatment response in triple-negative breast cancer (TNBC) still primarily relies on tumor size and ex vivo analyses, which provide very limited information on how tumors dynamically respond during therapy. In fact, oxidative stress rapidly emerges earl...

Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice

Early-life nutrition shapes lifelong health, yet the long-term consequences of childhood overnutrition, particularly on musculoskeletal aging, remain unclear. Here, we show that neonatal overfeeding acts as a developmental insult that accelerates age-related sarcopenia in both se...

TRIM3 functions as a tumor suppressor and predicts prognosis in triple-negative breast cancer: a multi-omics study with clinical cohort validation

Triple-negative breast cancer (TNBC) is an aggressive breast cancer subtype with poor prognosis and limited treatment options. Tripartite motif-containing protein 3 (TRIM3), an E3 ubiquitin ligase, has been implicated as a tumor suppressor in several cancers; however, its biologi...

Prostaglandin E2-mediated aging microenvironment fuels pathogenic fibrosis in cesarean section scar defect

Abstract With the increasing rates of cesarean section (CS), cesarean section scar defect (CSD) has become an escalating clinical concern due to uterine dysfunction and reduced fertility. However, the biological basis of CSD remains poorly understood, particularly the mechanisms...

RRM2/GCH1 signaling decreased cisplatin sensitivity in cervical cancer by modulating the ferroptosis process.

BACKGROUND: Cisplatin-based chemotherapy serves as a fundamental approach in the treatment of cervical cancer; however, its effectiveness is often hindered by the development of drug resistance, which presents a significant obstacle in clinical practice. METHODS: studies were car...

Persistent Zn 2+ Influx‐Mediated Deacetylation of ANXA2 Regulates the “Zn 2+ ‐Autophagic Flux” and Alleviates Intervertebral Disc Degeneration

ABSTRACT Intervertebral disc degeneration (IVDD) is an age‐related disease accompanied by disrupted mitochondrial homeostasis and defective autophagy. Cellular senescence induces ion imbalance, which leads to mitochondrial damage and suppressed autophagic flux; nevertheless, the...

PTBP1‐Mediated Alternative Splicing of DNAJB6 Promotes Everolimus Resistance in Clear Cell Renal Cell Carcinoma via EIF4B/PKIB/AKT/mTOR Positive Feedback Loop

ABSTRACT Background : Everolimus (EVE) is a key treatment for advanced clear cell renal cell carcinoma (ccRCC), mainly targeting AKT/mTOR signaling. However, developed resistance remains a major challenge for EVE treatment. Aberrant alternative splicing, particularly regulated by...

A scoping review of risk prediction models for low anterior resection syndrome in patients undergoing sphincter-preserving surgery for rectal cancer

To conduct a scoping review of risk prediction models for low anterior resection syndrome (LARS) in patients undergoing sphincter-preserving surgery for rectal cancer, with the aim of providing references for clinical nursing practice and future research. A scoping review methodo...

Preoperative prediction of MSI status in gastric cancer based on CT and radiomics: a multicenter study

To develop a non-invasive prediction model and assess its predictive power of microsatellite instability (MSI) status in gastric cancer (GC). This retrospective study included 1,012 GC patients from three hospitals during January 2019 and January 2023. Patients from hospital C we...

Psychometric properties of the Preschool Anxiety Scale in 2-6-year-old Chinese autistic children

Anxiety is a frequent comorbidity of autism spectrum disorder; however, early identification is hindered by a lack of validated assessment instruments for preschool autistic children. This study aims to evaluate the psychometric properties of the Preschool Anxiety Scale (PAS) in...

Ginsenoside Rh2 Attenuates Intervertebral Disc Degeneration by Modulating the PI3K/AKT Signaling Pathway to Suppress Apoptosis

Intervertebral disc degeneration (IVDD) is a major cause of chronic low back pain and imposes a substantial socioeconomic burden. Ginsenoside Rh2 (Gin-Rh2), a bioactive ginseng compound with antioxidant properties, may have therapeutic potential in IVDD, but its effects and under...

Deep learning integration of single-cell and spatial transcriptomics reveals a neutrophil-associated mesenchymal niche and a candidate translocon dependency in lung adenocarcinoma

In lung adenocarcinoma, epithelial–mesenchymal transition drives treatment resistance and metastasis but has been dissected mainly through SPP1 ⁺ macrophages, leaving neutrophils under-resolved; we asked whether integrating consensus non-negative matrix factorization, variational...

Effects of robot-assisted gait training on walking capacity and gross motor function in children with central nervous system impairments: a systematic review and meta-analysis predominantly based on cerebral palsy studies

Abstract Background Children with cerebral palsy (CP) and other central nervous system (CNS) impairments often have limitations in walking capacity and gross motor function. Robot-assisted gait training (RAGT) is increasingly used in pediatric rehabilitation, but existing evidenc...

Environmental and lifestyle determinants of skin ageing: Association between skin dryness and dyspigmentation in Chinese women

OBJECTIVE: To evaluate and classify the effects of seasonal and environmental variations on skin ageing features-specifically pigmentation disorders and dryness-in vivo in an Asian female population. METHODS: The skin characteristics of 200 Chinese women aged 20-70 years, residin...

A novel peptide interacts with RPL8 to alleviate portal hypertension by promoting ferroptosis

Liver fibrosis and mortal consequence of portal hypertension (PHT) is driven by hepatic stellate cells (HSCs) activation and their limited-explored property against elimination. We uncovered that HSC activation decreased the sensitivity to ferroptosis. By Ribo-seq, we identified...

Factors influencing family disease management and disease management difficulties in children with congenital gastrointestinal malformations: The roles of caregiver burden, social support, and family function

BACKGROUND: Children with congenital gastrointestinal malformations often have complex conditions that require long-term treatment and care, which can negatively impact their physical and mental well-being as well as their families, who play a crucial role throughout their treatm...

Ion‑Programmed In Situ J‑Aggregates Overcome Concentration‐Dependence for On‐Demand Phototherapy of Diabetic Bacterial Infections

ABSTRACT J‐aggregates are attractive for phototheranostics due to their enhanced absorption, redshift, and photostability, but they typically require high dye concentrations or nanocarriers. Inspired by Derjaguin–Landau–Verwey–Overbeek (DLVO) theory, in which multivalent ions pro...

From natural vesicles to intelligent carriers: the metabolic basis and biomedical applications of lemon-derived extracellular vesicles

Lemon-derived extracellular vesicles (LEVs) are a promising class of plant-based nanocarriers that have gained increasing attention for their biomedical potential. This review systematically summarizes recent advances in the isolation, characterization, composition, and therapeut...

Sitting Time and Physical Activity Correlate With Asthma Exacerbations in Adults: A Cross‐Sectional Study From the Australasian Severe Asthma Network

Summary Lower levels of sitting time were associated with a lower risk of severe asthma exacerbations in adults. High levels of physical activity eliminated the detrimental association of sitting time with severe asthma exacerbations in adults.