Xijing Hospital

Safety and Efficacy of Acute Normovolemic Hemodilution in Female Patients

Importance Female patients undergoing cardiac surgery have a higher transfusion burden, yet they remain underrepresented in randomized clinical trials. Although the ANH trial showed no significant reduction in the proportion of patients receiving allogeneic blood transfusions wit...

Clinical Outcome Differences in Asia Versus Non-Asia Intracerebral Hemorrhage: IPD Analysis From BP-Lowering Clinical Trials

BACKGROUND: Evidence of regional differences in clinical outcomes after intracerebral hemorrhage (ICH) is still scarce. We quantified differential outcomes and response to early intensive blood pressure lowering treatment by region in the Blood pressure in Acute Stroke Collaborat...

Treg‐stromal cell axis in tissue repair and autoimmune diseases: Mechanisms and clinical translation

Abstract Tissue repair and regeneration constitute a complex biological process, meticulously orchestrated by the immune system and stromal microenvironment. In this context, the dynamic crosstalk between regulatory T cells (Tregs) and stromal cells acts as the central regulatory...

CRISPR screening identifies TWIST1 as a ferroptosis driver in CKD progression

Chronic kidney disease (CKD) lacks effective therapeutic interventions targeting its fundamental pathological mechanisms. TWIST1 is a basic helix-loop-helix transcription factor that is a critical regulator in kidney fibrosis pathogenesis. We used genome-wide CRISPR-Cas9 screenin...

Advantage of cerebellar intermittent theta-burst stimulation in Alzheimer's disease (ACT-AD): study protocol for a multicenter, randomized, double-blind, sham-controlled trial

Abstract Introduction The cerebellum plays a crucial role in cognitive processing and thus presents a promising therapeutic target for Alzheimer’s disease (AD). This trial aims to evaluate the efficacy and safety of long-term, neuronavigated cerebellar intermittent theta burst st...

Association of dietary antioxidant patterns with heart failure risk in patients with hypertension

Hypertension is a major modifiable risk factor for heart failure (HF) and contributes substantially to the cardiovascular disease burden in China. Oxidative stress and redox imbalance have been implicated in the progression from hypertension to HF. The composite dietary antioxida...

Drp1 in M1 layer V GABAergic neurons orchestrates rTMS-mediated motor restoration and analgesia after spinal cord injury

Abstract Spinal cord injury (SCI) leads to chronic motor and sensory deficits, with progressive secondary neurodegeneration posing a major therapeutic challenge. Although high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the primary motor cortex (M1) show...

ZC3H13-Mediated m 6 A Modification of TRIM16 Suppresses EndMT and Atherosclerosis by Destabilizing Ang2 and Inhibiting the TLR4/NLRP3 Pathway

The RNA methyltransferase zinc finger CCCH-type containing protein 13 (ZC3H13) is downregulated in atherosclerosis (AS), but its functional mechanism remains unclear. Endothelial-mesenchymal transition (EndMT) is a core pathological driver of endothelial dysfunction in AS. This s...

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

ABSTRACT Traumatic brain injury (TBI) induces brain tissue ischemia, hypoxia, and heightened glycolysis, leading to lactate accumulation. Lactate exerts multiple pathophysiological effects in the aftermath of TBI. This study aimed to elucidate the role of lactate‐mediated lactyla...

Leveraging the Iron-Probe-MurB Interaction: An Enhanced Platform for PET Imaging of Bacterial Infections

Abstract The accurate discrimination of bacterial infections from sterile inflammation is a critical yet unresolved challenge in clinical diagnostics. To address this, we designed and synthesized a series of 68Ga-labeled PET tracers derived from the FDA-approved iron chelator, de...

Decoding patients’ voices: how social media reviews reveal the true impact of medical service

An increasing number of patients share their medical experience on social media, which are valuable resources for improving medical services and patient experience. This study focused on several top-tier large general Grade-A tertiary hospitals in China. It collected and organize...

Hydrogen-bonded organic framework-reinforced piezoelectric scaffolds for guided in situ bone regeneration

The fibrin network formed during the early bone repair establishes a viscoelastic micromechanical niche that recruits cells and releases cytokines, playing a pivotal role in primary callus formation. However, conventional metallic implants often lack these dynamic, bioactive cues...

Comparison of a Novel Occluder Versus Traditional Occluder in Atrial Septal Defect: A Randomized Trial

Background Traditional occluders for atrial septal defect have 2 drawbacks: incomplete endothelialization and difficulty in achieving atrial septum puncture post implantation. The novel occluder ReAces was designed to address these 2 clinical pain points. In this study, we aimed...

The evolution of research paradigms in cancer research in China within the framework of holistic integrative medicine

The traditional medical model has driven significant advances in oncology research; however, its excessive focus on molecular details, which hinders a holistic understanding of patients, has become increasingly evident as a limitation. As an emerging medical paradigm, holistic in...

Circumferential pulmonary vein isolation (CPVI) with adjunctive linear ablation vs. CPVI alone for long-standing persistent atrial fibrillation (SINUS): study protocol for a prospective, multi-center, randomized controlled trial

Previous studies have shown that circumferential pulmonary vein isolation (CPVI) alone has a relatively lower success rate for long-standing persistent atrial fibrillation (LSPAF). This study aims to compare the efficacy and safety between CPVI combined with modified linear ablat...

Preoperative renin-angiotensin system inhibitor management and acute kidney injury after cardiac surgery: a systematic review and meta-analysis

The optimal management of renin-angiotensin system inhibitors (RASIs) before cardiac surgery remains uncertain. Recommendations regarding continuation and preoperative temporary withholding and discontinuation differ, and the comparative effects of specific withdrawal timings on...

EPHX2 Loss Promotes CRC Migration via EET ‐Dependent Chemokine Elevation and Mitochondrial Defect

ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and carcinogenesis. However, the role and mechanism of EPHX2 in colorectal cancer (CRC) migrati...

Impact of Sievers morphology on fibro-calcific remodeling in severe bicuspid aortic valve stenosis: Exploratory findings from sex-stratified analyses

Abstract Aims Aortic stenosis (AS) is the most frequent valvular complication of bicuspid aortic valve (BAV), characterized by progressive fibro-calcific remodeling of the valve leaflets, but whether Sievers morphology (type 0 vs. type 1) influences tissue composition and whether...

Reconstruction of traumatic proximal femoral bone defects with personalized 3D-printed porous Ti-6Al-4V prosthesis: a case report and literature review

Abstract Background Reconstruction of critical-sized proximal femoral defects caused by high-energy trauma remains a formidable orthopedic challenge due to compromised mechanical stability, anatomical complexity, and limited biological integration capacity. Traditional methods (a...

Neoadjuvant Anbenitamab and HB1801 in ERBB2 -Positive Breast Cancer

IMPORTANCE The combination of neoadjuvant taxanes with trastuzumab and pertuzumab remains the cornerstone treatment strategy in ERBB2 -positive breast cancer. Anbenitamab (a ERBB2 -biparatopic antibody that induces profound receptor clustering) and HB1801 (a solvent-free albumin-...