Xijing Hospital

Novel customized 3D-printed prosthesis for complex infected bone defects: a clinical case series

Infected bone defects, especially irregular or long-segment defects, pose great clinical challenges. By performing bone defect reconstruction on patients with complex infected bone defects admitted to our hospital, this study explores the clinical efficacy of a novel customized 3...

CACA guidelines for the management of adult cancer pain

Abstract Cancer pain, one of the most prevalent and distressing symptoms in cancer patients, is closely associated with cancer diagnosis, therapeutic interventions, quality of life, and survival outcomes. Effective cancer pain management requires multidisciplinary collaborative a...

An integrative view of bile acids

Abstract Bile acids (BAs) are an important metabolic product in the human body, synthesized by the liver and existing in the form of steroid molecules. They are primarily excreted into the intestine via the gallbladder to assist in the digestion and absorption of fats. While the...

Chinese expert consensus on extraintestinal manifestations of inflammatory bowel disease

Inflammatory bowel disease (IBD) is a chronic, relapsing, inflammatory condition of the gastrointestinal tract that primarily includes Crohn's disease and ulcerative colitis. Beyond the typical gastrointestinal symptoms, IBD is frequently associated with various extraintestinal m...

Elucidating relationships among upward social comparison on social networking sites (SNSs), depressive symptoms, and SNS addiction in college students: insights from structural equation modeling and network analysis

With the burgeoning prevalence of social networking sites (SNSs), the likelihood of upward social comparison on SNSs has concomitantly escalated, particularly among college students. Notably, upward social comparison on SNSs has been linked to negative emotions and problematic be...

NOSES-facilitated transoral en-bloc excision of tongue squamous cell carcinoma via an adapted face-lift method: an initial technical case series

Tongue squamous cell carcinoma (TSCC) is one of the most common malignancies of the oral cavity, and cervical lymph node status is a major determinant of prognosis. Conventional selective neck dissection (SND) requires a transcervical incision that may result in visible cervical...

Targeting PRMT5 to reshape the immune microenvironment and reverse Trop2 ADC resistance in triple-negative breast cancer

Triple-negative breast cancer (TNBC) patients often develop resistance to Trop2 antibody-drug conjugate (ADC), and plasmacytoid dendritic cell (pDC) dysfunction is associated with poor prognosis in TNBC, but the underlying mechanism linking these two phenomena remains unclear. Th...

DMH glutamatergic and GABAergic neurons differentially regulate post-anesthesia sleep disturbance through CB1R signaling

Abstract Purpose Post-operative sleep disturbance affects more than 60% of surgical patients and impedes recovery. Although general anesthesia itself may profoundly remodel brain function and contribute to this pathology, the underlying neural mechanisms remain unclear. We previo...

Incidence, risk factors and prognostic impact of venous thromboembolism in patients with advanced non-small cell lung cancer receiving systemic therapy: a single-center retrospective analysis

To evaluate the incidence, timing, risk factors, and prognostic impact of venous thromboembolism (VTE) in patients with advanced non-small cell lung cancer (NSCLC) receiving systemic therapy. This single-center retrospective cohort study included 164 consecutive patients with pat...

Determinants of blood donation among Chinese university students: A structural equation modeling study based on an extended theory of planned behavior

PURPOSE: Recruiting young blood donors remains challenging. This study proposed and tested an Extended Theory of Planned Behavior (ETPB) model incorporating knowledge and donation-related anxiety to understand the psychosocial correlates of blood donation among Chinese university...

Fingolimod overcomes cisplatin resistance in esophageal squamous cell carcinoma by targeting NUP54 to disrupt homologous recombination repair

Cisplatin resistance is a major obstacle in the treatment of esophageal squamous cell carcinoma (ESCC). To address this challenge, we screened a U.S. Food and Drug Administration (FDA)-approved drug library and identified fingolimod, an immunomodulatory agent, as a potent inhibit...