Wuxi People's Hospital

Self-reported pain, depressive symptoms and risk for cardiovascular diseases

Previous studies have found that both pain and depressive symptoms are deleteriously associated with cardiovascular diseases (CVD). The aim of current study was to investigate the joint association of pain and depressive symptoms with CVD risk. A total of 13,184 participants aged...

Dose‒response relationship between tooth loss and cognitive impairment in older adults

Abstract Background In recent years, associations between oral health factors, including tooth loss, and cognitive function have received increasing attention. However, the dose-response association between tooth loss and cognitive impairment remains incompletely understood. Obje...

Nanozymes in Upper Respiratory Tract Infections: Catalytic Mechanisms, Current Evidence, and Emerging Theranostic Strategies

Abstract Objective: This review evaluates nanozymes as catalytic biomaterials for upper respiratory tract infection (URTI)-related diagnosis, therapy, and prevention, with particular attention to differences in the maturity of evidence across these applications. The anatomically...

WTAP-induced upregulation of KDR ameliorates angiotensin II-induced apoptosis, oxidative stress and ferroptosis of human brain microvascular endothelial cells

Abstract Background Intracranial aneurysms (IAs) are a significant cause of morbidity and mortality, often leading to subarachnoid hemorrhage and subsequent neurological deficits. The kinase insert domain receptor (KDR) plays a crucial role in vascular cell function during IA. Ho...

Targeting the CD4+ effector memory T cells re-expressing CD45RA suppressor galectin-7: a multi-omics-guided therapeutic strategy for idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease with limited therapeutic options. Although single-cell and spatial transcriptomics have revealed cellular heterogeneity within the IPF lung microenvironment, the immune drivers with causal rel...

PTTG1 drives intestinal-type gastric cancer progression via G2/M checkpoint-mediated cell-cycle reprogramming

Intestinal-type gastric cancer (IGC) progresses through the Correa cascade, yet the molecular determinants of this transition remain insufficiently defined. Using single-cell RNA sequencing (scRNA-seq) on matched normal, intestinal metaplasia, and tumor tissues from five patients...

Dydrogesterone and LNG-IUS for preventing postoperative recurrence after hysteroscopic surgery in patients with endometrial polyps and simple endometrial hyperplasia: a retrospective cohort study

Abstract Background Endometrial polyps (EPs) and non-atypical endometrial hyperplasia (EH) frequently cause abnormal uterine bleeding in reproductive-aged women. While hysteroscopy resects macroscopic lesions, postoperative recurrence is prevalent; progestogen therapy may mitigat...

Nicotinamide N-methyltransferase in tumor stroma–immune crosstalk: Metabolic–epigenetic mechanisms and translational opportunities

Nicotinamide N -methyltransferase (NNMT) transfers a methyl group from S-adenosylmethionine to nicotinamide, generating 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine and thereby linking nicotinamide disposal, nicotinamide adenine dinucleotide (NAD + ) salvage, and methy...

Influenza-associated Benign Acute Childhood Myositis

Background: To characterize the severity, clinical course, and 6-month outcomes of influenza-associated benign acute childhood myositis (BACM) during the 2024–2025 season and to explore differences between cases associated with influenza A and B. Methods: We retrospectively analy...

Hypoxia down-regulates METTL3 and WTAP activating Integrin/FAK signaling through m6A/IGF2BP3 dependent manners in TGFBI mRNA to promote pancreatic neuroendocrine neoplasms progression

Hypoxia along with N6-methyladenosine (m6A) plays crucial roles in human tumorigenesis by influencing nearly every aspect of RNA metabolism. Nevertheless, the physiological signals that regulate the equilibrium between methylation and demethylation under hypoxic conditions have y...

Association between age and outcomes of evidence-based feeding protocol versus usual care in critically ill patients: secondary analysis of a multicenter cluster-randomised controlled trial

BACKGROUND: Nutrition therapy is essential in critically ill patients, yet large randomised trials have shown inconsistent results regarding the effect of an evidence-based feeding protocol. The NEED trial showed a feeding protocol could effectively promote delivery of enteral nu...

Multicenter Evaluation of Large Language Models Versus Hepatologists for Prognostic Prediction in Drug‐Induced Liver Injury

BACKGROUND & AIMS: Drug-induced liver injury (DILI) would progress to chronicity or death. Large language models (LLMs) may enhance clinical decision-making, yet their utility relative to physicians in DILI remains unclear. Therefore, we evaluated their performance in predicting...

Food-Derived Antihypertensive Peptides: A Comprehensive Review of Preparation Strategies, Multitarget Mechanisms, and Machine Learning Advancements

Abstract Hypertension remains a major risk factor for cardiovascular disease worldwide and a formidable global health challenge. The clinical triumph of peptide-based drugs underscores the immense potential of bioactive peptides in hypertension management. Recently, food-derived...

Transcriptomic analyses identify TMPRSS4 as a shared biomarker in asthma and atopic dermatitis

Asthma and atopic dermatitis (AD) are common chronic inflammatory diseases that often co-occur, but the underlying shared biological mechanisms remain elusive. In this study, we performed WGCNA analyses on GSE6012 and GSE67472 datasets and identified 24 genes associated with both...

Combined effect of heart disease and high CRP levels on new-onset stroke in middle-aged and older Chinese adults: a prospective cohort study from CHARLS

Abstract Background This study aimed to investigate whether the coexistence of heart disease and high C-reactive protein (CRP) levels increases the risk of new-onset stroke among middle-aged and elderly Chinese individuals. Methods The analysis incluCombined Effect of Heart Disea...

YTHDC1 Orchestrates Glucose and Glutamate Rewiring to Overcome Lethal Metabolic Stress in Triple‐Negative Breast Cancer

ABSTRACT Developing effective therapies for triple‐negative breast cancer (TNBC) requires the identification of key molecular regulators. Here, among the major m6A modulators, we find that only the reader YTHDC1 is specifically overexpressed in TNBC and correlates to unfavorable...

Risk Factors of Postoperative Atelectasis and the Preventive Effect of a Risk-Stratified Nursing Model in Elderly Patients With Severe Polytrauma

AIM: To investigate the incidence and independent risk factors for postoperative atelectasis in elderly patients with severe polytrauma, and to evaluate the preventive effect of a risk-stratified nursing model developed based on these factors.METHODS: This retrospective study com...

Effect of SEEKflex-guided versus conventional intubation on hemodynamic responses in elderly hypertensive patients: a randomized controlled trial

In elderly patients with preexisting cardiovascular and cerebrovascular diseases, laryngoscopy and tracheal intubation can provoke substantial hemodynamic disturbances, including hypertension and tachycardia, which may precipitate major cardiovascular or cerebrovascular events an...

Extraction-reasoning gaps in open-source LLM grading of liver pathology reports

Large language models (LLMs) may reduce the manual effort required to convert narrative pathology reports into structured research data, but it remains unclear whether their performance reflects extraction of explicit diagnostic labels or genuine histopathological reasoning. We e...

Contrastive Learning Network based on Multi-Scale Transformer (CLMT-net): EEG decoding for fine-grained motor imagery of movements within the same limb

Motor imagery (MI)-based brain-computer interfaces (BCIs) decode EEG signals into control commands. However, fine-grained MI decoding within the same limb remains challenging due to highly similar neural patterns. This paper proposes a Contrastive Learning Network based on a Mult...