Wroclaw Medical University

Surgical Ablation for Atrial Fibrillation During Minimally Invasive Mitral Valve Surgery: Risk Dependencies and Long-Term Survival

Objective: Atrial fibrillation (AF) is a common finding among patients with mitral valve disease, with a growing body of evidence showing survival benefits associated with surgical ablation (SA). However, a lack of data persists regarding the safety and survival after SA concomit...

Physicochemical characterization and in vitro biological evaluation of TPGS-stabilized cationic nanoliposomes for 8-bromo-6-chloroflavone delivery

Abstract Flavonoids with halogen substituents represent a promising group of bioactive compounds, but their poor aqueous solubility and limited bioavailability restrict their therapeutic application. This study aimed to develop and evaluate a SPC/cholesterol/TPGS/DOTAP-modified c...

Glycemic burden during nocturnal sleep in patients with sleep bruxism across sleep stages

OBJECTIVE: To assess nocturnal glycemic burden across sleep stages in adults with polysomnographically confirmed sleep bruxism. METHODS: 95 adults underwent polysomnography, bilateral masseter electromyography, and continuous glucose monitoring. 70 participants with BEI ≥2 events...

Exploring Professional Experiences in Caring for Vulnerable Migrants in an Italian Rural Reception Centre: A Qualitative Study Using Multidimensional Textual Analysis—Professional Experiences in Rural Migrant Care

ABSTRACT Aim This study aims to explore the experiences, strengths, challenges, and potential improvements for professionals in managing the complex needs of vulnerable migrants (VM) in an Italian rural reception centre. Methods A qualitative study using semi‐structured interview...

Clinical characteristics associated with failure to achieve a prespecified guideline-directed medical therapy target at discharge in patients with HFrEF undergoing scheduled hospitalization: a secondary analysis of the HEROES study

Abstract Guideline-directed medical therapy (GDMT) is crucial for the pharmacological management of heart failure (HF) with reduced ejection fraction (HFrEF). The aim of the study was to identify clinical characteristics associated with failure to achieve the prespecified stringe...

Ontology-level serum and tumor–margin lipid remodeling across colorectal cancer progression: a cross-sectional study

Colorectal cancer (CRC) progression involves extensive metabolic reprogramming, but stage-related lipid alterations across circulating and local tissue compartments remain incompletely characterized. This study aimed to map serum and paired tumor–margin ontology-level lipid signa...

Sleep, Stress, Circadian Rhythm, and Diet in Pediatric Disorders of Gut–Brain Interaction: A Narrative Review

Pediatric disorders of gut–brain interaction (DGBIs) comprise chronic or recurrent symptom-based gastrointestinal conditions that cannot be fully explained by identifiable structural, biochemical, or organic abnormalities after appropriate clinical evaluation. The term DGBI is us...

Intraoperative Techniques Aiding Margin Assessment and Nerve Sparing During Robot-Assisted Radical Prostatectomy

Robot-assisted radical prostatectomy (RARP) requires a balance between complete cancer excision and preservation of urinary continence and erectile function. Because the preservation of neurovascular bundles adjacent to the prostate surface contributes to postoperative functional...

Morphology of third mandibular molars – an in vivo cone beam computed tomography study in Lower Silesia

<title>Abstract</title> Background Understanding the root and canal morphology of mandibular third molars (MTMs) is crucial for anatomical characterization of human dentition and effective endodontic treatment. This study investigates the number of roots, canal configurations, an...

Effects of Additive Incorporation on Fluoride Release of Orthodontic Glass Ionomer Cements and Adhesives: A Systematic Review

This systematic review evaluated the effects of functional additives on fluoride release, fluoride recharge/re-release, and selected mechanical, physical, and biological properties of orthodontic glass ionomer cements (GICs) and glass ionomer-based adhesives. The review followed...

Illness Acceptance Among Adults with Melanoma: A Prospective Observational Cross-Sectional Study

Introduction: Melanoma is a chronic disease that significantly affects patients’ daily functioning and emotional well-being. Beyond its somatic burden, it often leads to substantial changes in quality of life (QoL). This study aimed to assess illness acceptance among melanoma pat...

Context Dependent Effects of Probiotics: A Systems Perspective on the Interpretation of Experimental Findings

Current definitions of probiotics emphasize their beneficial effects on the host but do not fully capture the complexity of their interactions within the host. Most experimental models remain reductionist, focusing on individual probiotic strains rather than the biological system...

Diagnostic and therapeutic significance of selected antibodies against advanced glycation end-products (anti-AGEs)

The aim of this review is to summarize current knowledge on the diagnostic and therapeutic significance of antibodies against advanced glycation end-products (anti-AGEs). AGEs are formed through non-enzymatic reactions of reducing sugars with proteins, lipids, and nucleic acids,...

Towards Personalized Medicine in Chronic Kidney Disease: A Roadmap for the future of Early Detection, Diagnosis, and Management: A Consensus Roadmap from the EUTox, PerMedik and KidneyHealth networks

Chronic kidney disease (CKD) affects more than 800 million individuals worldwide and represents one of the fastest‑growing causes of morbidity and mortality. Despite major therapeutic advances, CKD is frequently detected only after substantial and irreversible loss of kidney func...