Wroclaw Medical University

From Chronic Infection to Microbial Imbalance: Rethinking Chronic Rhinosinusitis

Chronic rhinosinusitis (CRS) has traditionally been viewed as a chronic inflammatory disease in which microbial factors are implicated. However, increasing evidence suggests that CRS may be better understood as a disruption of sinonasal microbial homeostasis rather than as a chro...

Molecular Interactions of Bioactive Peptides with Proteins and DNA

Background: This study investigates the molecular recognition of two biologically active peptides (P1 and P2) by key biomacromolecular targets. The studied peptides were previously identified in Babylon snail hydrolysates and have been shown to exhibit antioxidant and cytotoxic a...

Is Aging a Failure to Resolve? Integrating Damage Responses, Regenerative Decline, and Geroscience Interventions

Biological aging is accompanied by persistent tissue-damage signaling, chronic inflammation, extracellular matrix remodeling, cellular senescence, and declining regenerative capacity. Taken together, these features resemble an injury response that is repeatedly initiated but fail...

The Sulfate-Reducing Bacteria Hypothesis in Parkinson’s Disease: From Desulfovibrio-Derived Hydrogen Sulfide to Alpha-Synuclein Aggregation

The conceptualization of Parkinson’s disease (PD) has shifted from a strictly central neurodegenerative disorder to a systemic synucleinopathy that may, in some patients, originate in the enteric nervous system. This review synthesizes recent evidence highlighting the potential r...

Sacituzumab govitecan in heavily pretreated metastatic triple-negative breast cancer: a secondary analysis of the CEBCC-102 real-world cohort

Abstract Background Real-world evidence on sacituzumab govitecan (SG) in heavily pretreated patients with metastatic triple-negative breast cancer (mTNBC) remains limited. This study assessed SG outcomes in a multicentre Central European cohort. Methods This retrospective study i...

Drug-Initiated Synthesis and Processing of Mupirocin–PLGA Conjugates for Biodegradable Antibacterial Scaffolds

Abstract Mupirocin–poly(lactic-co-glycolic acid) (Mup-PLGA) conjugates were developed via drug-initiated ring-opening polymerization to create biodegradable scaffolds with local antibacterial activity. Conjugate composition and molecular weight were controlled to tune degradation...

Translation, Cultural Adaptation and Psychometric Validation of the Italian Version of the Dignity in Care Scale for Nurses

AIM: To translate, culturally adapt and validate the Dignity in Care Scale for Nurses (DISC-N) into the Italian language. DESIGN: A national multicentre cross-sectional study. METHODS: Translation and cultural adaptation followed recognised guidelines for health measurement instr...

Effect of Additional Surface Conditioning Methods and Adhesive Systems on Microleakage at Composite Repair Interfaces: An in Vitro Study

Repair of aged resin composites requires additional surface conditioning and an adhesive protocol capable of limiting interfacial leakage. This in vitro study evaluated three additional conditioning methods and two adhesive systems at aged composite–new composite repair interface...

Beyond the Monomer: Camphorquinone, TPO, and BAPO as Leachates of Light-Cured and 3D-Printed Dental Polymers—Radical Chemistry, Redox Signalling, and the Dose-Realism Gap

Research on the biological cost of resin-based dental materials has focused almost exclusively on residual methacrylate monomers. The photoinitiators—camphorquinone (CQ) with its amine co-initiator, and the acylphosphine oxides TPO and BAPO—remain partly unconsumed, can elute, an...

Thrombosis of a femoropopliteal vein graft as a complication of COVID-19 vaccination, with subsequent recanalization of the graft following gene therapy

Chronic limb-threatening ischemia (CLTI), formerly referred to as critical limb ischemia (CLI), is characterized by ischemic rest pain and tissue loss (ulceration or necrosis) in the presence of objectively documented arterial insufficiency, and is associated with a high risk of...

Smoking behaviours and attitudes among dental students in three European countries: a multicentre cross-sectional study

Tobacco use remains a major public health concern and a significant risk factor for systemic and oral diseases. Dental students, as future healthcare professionals, are expected to play an important role in tobacco control and smoking cessation. This multicentre study aimed to as...

Lipoprotein(a) and Prostate Cancer: A Systematic Review of Observational, Genetic and Mendelian Randomization Evidence

Cancer is a major cause of morbidity worldwide. Prostate cancer (PCa) is one of the most commonly diagnosed malignancies in men and is clinically heterogeneous, highlighting the need for additional biomarkers that may improve risk stratification. Lipoprotein(a) [Lp(a)] is a genet...

Mitochondrial Modulation as a Therapeutic Entry Point in Neurodegeneration

Mitochondrial dysfunction is a recurrent but context-dependent feature of neurodegenerative disease, and its position in the pathogenic cascade differs fundamentally between disorders. This narrative review argues that this heterogeneity, rather than mitochondrial biology itself,...

Intracellular Crosstalk Between NMDA and Sigma-1 Receptors: A Novel Mechanistic Insight Relevant to Neuropsychiatric Pharmacotherapy

Formerly recognized as an opioid receptor, the sigma-1 receptor (σ1R) is a multifunctional chaperone protein that plays a crucial role in regulating neuronal signaling, neuroprotection, and synaptic plasticity. Increasing evidence highlights a tight functional association between...

Chronic Spontaneous Urticaria in the Era of Targeted Therapy: From Pathogenic Mechanisms to Precision Medicine

Chronic spontaneous urticaria (CSU) is a common and heterogeneous inflammatory skin disease characterized by recurrent wheals and/or angioedema for more than six weeks. Despite treatment with second-generation antihistamines, many patients remain symptomatic, highlighting the nee...

Environmental Sustainability-Related Knowledge, Behaviors, and Perceived Barriers Among Italian Intensive Care Unit Nurses: A Cross-Sectional Survey

Background/Objectives: Healthcare systems are increasingly recognized as contributors to climate change, and intensive care units represent particularly resource-intensive clinical environments. Nurses play a central role in shaping daily care practices that may influence the env...

Association Between Self-Reported Weekly Physical Activity Duration and Echocardiographic Cardiac Structure and Function in Adults Aged ≥ 45 Years: A Cross-Sectional Study

Background: The association between habitual physical activity duration and cardiac structure and diastolic function remains incompletely characterized. Objective: To evaluate the relationship between self-reported weekly physical activity duration and echocardiographic parameter...

Quality of life, caregiver burden, and clinical correlates in Kabuki syndrome: a cross-sectional observational study

Kabuki syndrome (KS) is a rare multisystem neurodevelopmental disorder caused by pathogenic variants in KMT2D or KDM6A . We examine quality of life (QoL), its correlates, patterns of rehabilitation utilization, patient functioning, and caregiver burden in a Polish patient group....

Autologous Tissue Grafts for Chin Augmentation with or Without Genioplasty: A Systematic Review

Objective: This systematic review evaluated the clinical application of autologous tissue grafts for chin augmentation performed with or without genioplasty. The primary outcomes included clinical and aesthetic improvement, graft stability and integration, resorption, complicatio...

Clear Aligners as a Prescribed Source of Unmeasured Intra-Oral Micro- and Nanoplastic Exposure: Release Mechanisms, Human Evidence, Salivary Biomonitoring and the EU Regulatory Context

Clear orthodontic aligners are removable polymer devices worn about 22 h a day for 12 to 24 months, increasingly by children. A growing in vitro literature shows that thermoformed and 3D-printed aligners shed micro- and nanoplastics and co-release elemental or organic constituent...