West China Medical Center of Sichuan University

Social determinants of health and lifestyle in the progression of degenerative bone and joint diseases: a prospective multi-state analysis

Abstract Aims The role of social determinants of health (SDOH) in the progression of degenerative bone and joint diseases (DBJDs) - from initial onset to multimorbidity and mortality - remains unclear. We aimed to assess the associations of SDOH with DBJDs progression, examine th...

Engineered desialylated platelet membrane camouflaged liposomes for the regulation of kupffer cells and hepatic stellate cells in treatment of liver fibrosis

The intercellular crosstalk and reciprocal activation between Kupffer cells (KCs) and hepatic stellate cells (HSCs) are critical drivers of liver fibrosis progression. Nonetheless, the co-regulation of KCs and HSCs is hindered by their distinct anatomical locations and the pathol...

Fructose induces PERK-dependent ER stress and mitochondrial dysfunction via nucleotide depletion in clear cell renal cell carcinoma

Abstract Clear cell renal cell carcinoma (ccRCC) exhibits a paradoxical fructose metabolism signature characterized by upregulation of the fructose transporter GLUT5 alongside downregulation of the catabolic enzymes (ketohexokinase, aldolase B, and triokinase), a pattern associat...

The relationship between hemoglobin concentration in the third-trimester and gestational age, birth weight of newborns: stratified analysis based on maternal age

This study retrospectively analyzed the association between hemoglobin concentration in the third trimester of pregnancy and neonatal gestational age and birth weight, and further explored whether there were differential effects between advanced maternal age and women of reproduc...

Longitudinal dynamics of the maternal gut virome associate with metabolic features of preterm birth

Preterm birth (PTB) remains a major pregnancy complication, yet the role of the maternal gut virome in its etiology is largely unknown. Here we show that the maternal gut virome undergoes ecological destabilization prior to PTB, coupled with distinct host metabolic remodeling. Ne...

Advances in collagen-based materials for tissue-engineered meniscus

Meniscus possesses weak self-repairability once getting hurt due to heterogeneity, particularly “white region” of avascular parts. However, the effect of conventional therapies in restoring structure and function of the meniscus isn’t ideal. Collagen, a key part of the extracellu...