Wellcome Centre for Human Neuroimaging

The metacognitive paradox of OCD: confidence is globally reduced but shows increased sensitivity to local evidence

Confidence is a critical metacognitive signal that guides performance. Biases in confidence, such as excessive doubt, are hallmark features of mental health disorders, especially obsessive-compulsive disorder (OCD). Yet, the underlying neurocognitive mechanisms and how they link...

Estimating differing causal roles of glutamate and GABA genes on brain and behavior in autism

Abstract The excitatory/inhibitory (E/I) imbalance theory suggests that excitatory and inhibitory alterations underlies autism characteristics. However, genetic underpinnings of this imbalance and its impact on brain function and behavior remains unclear. We explored causal links...

CB1 receptor-enriched functional connectivity analysis revealed target-specific modulation by cannabidiol in early psychosis

BACKGROUND: Cannabidiol (CBD) has emerged as a potential antipsychotic treatment, acting as a negative allosteric modulator of cannabinoid type-1 (CB1) receptors within the endocannabinoid system. Although previous neuroimaging studies have shown that CBD induces changes in aberr...

An elementary form of agency at planetary-scale

Abstract The claim that climate homeorhesis—non-equilibrium steady-state dynamics that underlie Earth’s long-term habitability—depends on an integrated biosphere–climate system capable of acting on its own is central to debates surrounding the Gaia hypothesis. This paper presents...