Weizmann Institute of Science

Disordered Gibbs measures and Gaussian conditioning

Abstract We study the law of a random field $$f_N(\varvec{\sigma })$$ f N ( σ ) evaluated at a random sample from the Gibbs measure associated to a Gaussian field $$H_N(\varvec{\sigma })$$ H N ( σ ) . In the high-temperature regime, we show that bounds on the probability that $$f...

High–spatiotemporal resolution deuterium metabolic imaging enables in vivo phenotyping of intra- and intertumoral heterogeneity

Intra- and intertumoral heterogeneities raise fundamental biological questions and have important implications for accurate cancer diagnosis, prognosis, and treatment. These heterogeneities reflect tumor complexity, including a pronounced diversity in metabolic phenotypes and pro...

Human Hsp70 paralogs display selective J-domain interactions tuning proteostasis under stress

Hsp70 chaperones are central regulators of proteostasis, mediating folding, refolding, degradation, and aggregation-prevention. Their activity is tuned by the diverse J-domain proteins (JDPs), which both recruit client proteins and stimulate Hsp70 ATP hydrolysis via interaction w...

Beta-lactam antibiotics have immunomodulatory effects in vitro, including changes consistent with sepsis-induced immunosuppression

Abstract Introduction Sepsis is associated with immunosuppression, predisposing patients to secondary infections. Many treatments routinely used for infections have immunomodulatory effects, including antibiotics. We therefore assessed the immunomodulatory effects of beta-lactam...

Symmetry-Broken Biphasic WS2 NanowhiskeredHeterostructures Enable Field-Induced NO2 Sensing

Abstract Van der Waals (vdW) materials have garnered ample interest as next-generation sensors and catalysts, owing to high surface-to-volume ratio, defect tunability, easy modulation of active sites, and convenience in device fabrication. However, one major drawback delimiting s...

Enhanced dynamic range spatio-spectral metrology of few-cycle laser pulses

Accurate spatio-temporal and spatio-spectral metrology is critical to the characterization and use of ultra-short, highpower lasers.The emergence of few cycle pulses, with bandwidths of tens or hundreds of nanometers, poses a significant challenge to existing metrology techniques...

Pine root exudate terpenoids associate with Mycobacterium sp. under summer drought in a mixed Mediterranean forest

Abstract Background Interactions between tree root exudates and rhizosphere bacteria are a key pathway influencing tree health in the forest. However, how this interaction occurs at the chemical level belowground in forest soil still remains unclear. We conducted a 2-year field e...