Weifang Medical University

Development and validation of machine learning models for preoperative prediction of perioperative outcomes in patients with thymic epithelial tumors

Thymic epithelial tumors (TETs) are rare anterior mediastinal tumors with heterogeneous perioperative recovery. We developed and externally validated machine-learning models using preoperative and preoperatively available variables to predict postoperative complications, prolonge...

Endovascular treatment guided by tissue window rather than time window may be safe and feasible in patients with ischemic stroke

For progressive stroke caused by large vessel occlusion (LVO) beyond the 24-hour time window, dedicated evidence for endovascular treatment (EVT) remains scarce, and there is currently no established treatment standard. We investigated the safety and feasibility of tissue window-...

Harnessing hydrogel technology for advanced periodontitis therapy: A multifunctional approach to oral health restoration

Periodontitis is a bacterially driven inflammatory disease that can lead to tooth mobility and tooth loss. Conventional non-surgical therapy, antibiotics, and surgery may be limited by residual subgingival biofilms, antimicrobial resistance, and variable clinical outcomes. This r...

MRI Visualization of Melatonin‐Promoted Oligodendrogenesis and Its Neuroprotective Effects in Preterm White Matter Injury Rat Model

Preterm white matter injury (PWMI) is a serious neurologic condition that threatens neonatal survival and severely impairs the cognitive and motor development of affected children. Melatonin (Mel), a neuroendocrine hormone with anti-inflammatory and antioxidant properties, has sh...

Moldavoside ameliorates hypertension and autoantibodies targeting the angiotensin II type 1 receptor-induced endothelial damage via regulation of RhoE/CAV-1/eNOS axis

Globally, more than 100 million patients with resistant hypertension experience severe endothelial damage. Therefore, exploring the mechanisms underlying endothelial damage and developing effective interventions is urgently required. The clinical data and biochemical indicators o...

Arterial‐Ventricular Coupling Strain Index as an Independent Predictor of 10‐Year ASCVD Risk in Diabetic‐Hypertensive Patients

BACKGROUND AND AIMS: The combination of diabetes mellitus and hypertension significantly increases the risk of cardiovascular diseases (CVD). This study aimed to evaluate the association between ventricular-arterial coupling and the 10-year atherosclerotic cardiovascular disease...

Exploring the potential role of ADRB1 as a suppressor gene and prognostic biomarker in lung adenocarcinoma: a comprehensive bioinformatics analysis

Lung adenocarcinoma (LUAD) is the most common pathological subtype of lung cancer. Sympathetic activation remodels the tumor microenvironment through β-adrenergic receptors (β-ARs) and is associated with malignant progression. Research mainly focuses on β 2 -AR, while the role of...

Complex exposure–response relationships between meteorological factors and severe fever with thrombocytopenia syndrome risk

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne infectious disease influenced by meteorological factors. This study aimed to characterize the complex exposure–response relationships between multiple meteorological factors and SFTS risk in Anhui Provin...

School-based hygiene intervention to prevent Helicobacter Pylori infection among children (SHIP HOPE): a cluster-randomized controlled trial

Helicobacter pylori ( H. pylori ) is a major cause of gastric cancer and is typically acquired during childhood. Preventing infection in uninfected children is a promising strategy; however, the effectiveness of hygiene-based interventions remains uncertain. This study aimed to d...

Preparation methods, mechano-bactericidal performance and mechanisms of Ti-based nanostructure arrays: A review

Medical titanium (Ti) and its alloys have been widely employed in biomedical field, but Ti-based implants are prone to bacterial biofilm contamination, leading to implant failure. Nanostructure arrays, as a new strategy, exhibit effective bactericidal performance and biofilm inhi...

Bag-1 modulates lung ischemia-reperfusion injury by regulating BCL-2 family proteins and IP3R-mediated calcium release

Lung ischemia-reperfusion injury (LIRI) involves dysregulated apoptosis and calcium overload. This study explored the role of molecular chaperone BCL-2-associated athanogene 1 (Bag-1) -1 in LIRI pathogenesis. Using an A549 cell model of glucose deprivation/hypoxia-reoxygenation,...

Balloon-assisted radial release for retrieval of a surgically suture-fixed inferior vena cava filter: a case report

The retrieval of an inferior vena cava (IVC) filter is essential for preventing complications related to the filter. Surgically induced suture fixation is an extremely rare cause of filter entrapment and presents unique technical challenges. This case describes a balloon-assisted...

Cervical small-cell neuroendocrine carcinoma mixed with squamous cell carcinoma first suspected on liquid-based cytology and confirmed by biopsy: a case report

Cervical small cell neuroendocrine carcinoma (SCNEC) admixed with squamous cell carcinoma (SCC) is a rare malignancy associated with a poor prognosis. While histological features of this mixed tumor have been described, liquid-based cytology (LBC) findings remain largely undocume...

Joint associations of non-intact family types and health-risk behaviors with mental health outcomes: evidence from a large-scale survey among adolescents in Shandong Province, China

Rising global divorce rates have increased the prevalence of non-intact families, which may be associated with adolescents’ behaviors and mental health. Non-intact family types (NIFTs) and health-risk behaviors (HRBs) are both associated with adolescent mental health, yet previou...

Comparative evaluation of selective media and key factors affecting isolation of V. cholerae and V. parahaemolyticus

Abstract Thiosulfate citrate bile salts sucrose (TCBS) agar is a widely used selective medium for the presumptive isolation of Vibrio spp, playing an essential role in food safety and public health surveillance. However, variations among commercial formulations may significantly...

Myasthenia gravis complicated by myocarditis associated with anti-titin and anti-VGKC antibodies: a case report

Myasthenia gravis (MG) is an autoimmune neuromuscular junction disorder primarily affecting skeletal muscles. Although myocardial involvement is rare, MG-associated myocarditis can be life-threatening and may be overlooked because symptoms such as dyspnea and fatigue overlap with...

Healing of diabetic cutaneous wound mediated by small extracellular vesicles derived from mesenchymal stem cells

Abstract Diabetic cutaneous wounds, particularly diabetic foot ulcers, are among the most severe chronic complications of diabetes mellitus and remain a major clinical challenge because of persistent inflammation, oxidative stress, impaired angiogenesis, and delayed tissue regene...

Mechanism of Association Between Abnormity of Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase-Stimulator of Interferon Gene Pathway and Cardiovascular Diseases and the Exercise Regulation：A Review.

Cardiovascular diseases are one of the major factors affecting the life and health of people all over the world.Recent studies have found that the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes （cGAS-STING） signaling pathway is si...

Machine Learning–Based Cytokine Endotyping of Thyroid Eye Disease

Purpose: Thyroid eye disease (TED) exhibits profound phenotypic heterogeneity that conventional binary thyrotropin receptor antibody fails to capture. We aimed to deconstruct this heterogeneity by establishing a cytokine-derived molecular taxonomy. Methods: We profiled 102 plasma...

The role of SAM-dependent internal m7G modification of LINC01252 in the progression of hepatocellular carcinoma

Abstract Dysregulation of long non-coding RNAs (lncRNAs) plays a significant role in the progression of hepatocellular carcinoma (HCC), yet many underlying mechanisms remain elusive. Recent studies have highlighted the critical importance of internal N 7 -methylguanosine (m 7 G)...