Weifang Medical University

Clinical Efficacy of Neoadjuvant Camrelizumab Plus Chemotherapy for Triple‐Negative Breast Cancer and Tumor Immune Microenvironment Analysis: A Prospective‐Retrospective Cohort Study

ABSTRACT The impact of immune checkpoint inhibitors combined with neoadjuvant chemotherapy (NAC) on surgical outcomes and immune remodeling remains underexplored. To investigate the efficacy and tumor immune microenvironment (TIME) changes of camrelizumab plus NAC for triple‐nega...

Fructose induces PERK-dependent ER stress and mitochondrial dysfunction via nucleotide depletion in clear cell renal cell carcinoma

Abstract Clear cell renal cell carcinoma (ccRCC) exhibits a paradoxical fructose metabolism signature characterized by upregulation of the fructose transporter GLUT5 alongside downregulation of the catabolic enzymes (ketohexokinase, aldolase B, and triokinase), a pattern associat...

ID4 enhances ferroptosis sensitivity in gastric cancer by promoting ubiquitination degradation of GPX4

Gastric cancer (GC) is one of the most prevalent malignant tumors worldwide, presenting a serious threat to human health due to its high fatality rates and incidence. Ferroptosis, as a novel form of programmed cell death, demonstrates significant potential in cancer therapy. The...

Multiple Dynamic Covalent Bond Crosslinked Ionic Liquids-Based Hydrogel with Stretchable, Rapid Self-Healing and Antibacterial Activity Properties

The development of antibacterial hydrogel with stretchable and self-healing properties is an urgent problem in the field of biomedical engineering. Herein, a series of hydrogels with antibacterial activity was successfully fabricated using polyvinyl alcohol (PVA), borax, 4-formyl...

Active Free Radical Cold Atmosphere Plasma Promotes Healing of Diabetes Foot Ulcer: Mechanism and Challenge

BACKGROUND: Diabetic foot ulcers (DFUs) have become an important cause of disability and death in patients with diabetes. Traditional therapies are prone to problems such as recurrence and drug resistance, which result in unsatisfactory healing effects for DFUs. Although antibiot...

Associations of self-efficacy and learning engagement with humanistic caring ability among vocational college nursing students: a structural equation modeling study

Previous studies have investigated the associations of humanistic caring ability (HCA) with self-efficacy (SEF), or learning engagement (LN) among college students. There has been a lack of studies that examine the mediation effect of learning engagement between SEF and humanisti...

Biomechanical comparative analysis of minimally invasive decompression and minimally invasive fusion with internal fixation in the treatment of lumbar spinal stenosis with degenerative spondylolisthesis: a finite element study

This study aimed to analyze and compare the biomechanical effects of four different minimally invasive surgical procedures for lumbar spinal stenosis complicated by degenerative spondylolisthesis. A static finite element analysis was performed using data from a single healthy vol...

Lycium barbarum glycopeptide attenuates ischaemic stroke by inhibiting inflammation via SIRT3-mediated NLRP3 deacetylation

Background Inflammatory processes play a critical role in ischaemic stroke. Acetylation of NLRP3 is a key step in amplifying neuroinflammation. (LbGP), a bioactive glycoprotein derived from Lycium barbarum, has anti-inflammatory potential, but its mechanisms in post-stroke neuroi...